Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins
, 2007 G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
core
Specific motifs responsible for protein-protein interaction between cannabinoid CB1 and dopamine D2 receptors [PDF]
, 2006 Studying protein-protein interactions has been vital for understanding how proteins function within the cell, how biological processes are strictly regulated by these interactions, and what molecular mechanisms underlie cellular functions and diseases ...
Zhang, Yun
core
Serum contents of endocannabinoids are correlated with blood pressure in depressed women.
, 2012 BACKGROUND: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho, WS V +24 more
core +1 more source
The endogenous cannabinoid system gates plasticity of tonic GABA inhibition
The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
wiley +1 more source
Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. [PDF]
BMC Neurosci, 2023 Ranjbar H +4 more
europepmc +1 more source
Cannabinoid CB1 Receptors Are Expressed in a Subset of Dopamine Neurons and Underlie Cannabinoid-Induced Aversion, Hypoactivity, and Anxiolytic Effects in Mice. [PDF]
J Neurosci, 2023 Han X +7 more
europepmc +1 more source
Diferentes respostas reforçadoras e locomotoras induzidas pela ativação de endocanabinóide em ratos adolescentes e adultos das linhagens Wistar e Shr [PDF]
, 2007 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Várias evidências apontam para a adolescência como um período crítico para o início de uma ampla escala de ...
Pandolfo, Pablo
core
, 2013 (A) Immunohistochemical detection of CB1 and CB2 receptors in rat pancreatic tissue sections, with the arrowheads showing the specific CB1/CB2 staining. (B) Western blot staining of CB1 and CB2 receptors in rat pancreatic tissue lysates.
Ming-hua Cao (291257) +7 more
core +1 more source
, 2007 As the contribution of cannabinoid (CB1) receptors in the neuroadaptations following chronic alcohol exposure is unknown, we investigated the neuroadaptations induced by chronic alcohol exposure on both NMDA and GABA(A) receptors in CB1-/- mice.
Naassila, M +13 more
core +1 more source