Results 1 to 10 of about 607 (111)

Expression and Functions of the CB2 Receptor in Human Leukocytes

Frontiers in Pharmacology, 2022
The cannabinoid CB2 receptor was cloned from the promyeloid cell line HL-60 and is notably expressed in most, if not all leukocyte types. This relatively restricted localization, combined to the absence of psychotropic effects following its activation ...
Mélissa Simard, Mélissa Simard, Volatiana Rakotoarivelo, Volatiana Rakotoarivelo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Nicolas Flamand, Nicolas Flamand   +10 more
doaj   +3 more sources

CB2 cannabinoid receptor as potential target against Alzheimer’s disease

Frontiers in Neuroscience, 2016
The CB2 receptor is one of the components of the endogenous cannabinoid system, a complex network of signaling molecules and receptors involved in the homeostatic control of several physiological functions.
Ester eAso, Isidro eFerrer
doaj   +3 more sources

Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits

Frontiers in Neuroscience, 2022
Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing a key role in regulating neuronal function in the central nervous system.
Anthony S. Ferranti, Anthony S. Ferranti, Daniel J. Foster   +2 more
doaj   +1 more source

Cannabinoid CB2 Receptors Modulate Microglia Function and Amyloid Dynamics in a Mouse Model of Alzheimer’s Disease

Frontiers in Pharmacology, 2022
The distribution and roles of the cannabinoid CB2 receptor in the CNS are still a matter of debate. Recent data suggest that, in addition to its presence in microglial cells, the CB2 receptor may be also expressed at low levels, yet biologically relevant,
Samuel Ruiz de Martín Esteban, Irene Benito-Cuesta, Itziar Terradillos, Itziar Terradillos, Ana M. Martínez-Relimpio, M. Andrea Arnanz, Gonzalo Ruiz-Pérez, Claudia Korn, Catarina Raposo, Roman C. Sarott, Matthias V. Westphal, Izaskun Elezgarai, Izaskun Elezgarai, Erick M. Carreira, Cecilia J. Hillard, Uwe Grether, Pedro Grandes, Pedro Grandes, M. Teresa Grande, Julián Romero   +19 more
doaj   +1 more source

Cannabinoid receptors distribution in mouse cortical plasma membrane compartments

Molecular Brain, 2021
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons ...
Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B. Laprairie, Changiz Taghibiglou   +3 more
doaj   +1 more source

A Central Move for CB2 Receptors [PDF]

Neuron, 2016
The function of the CB2 cannabinoid receptor in the brain has long been a matter of debate. In this issue of Neuron, Stempel et al. (2016) describe a mechanism whereby endocannabinoid production leads to a cell-intrinsic hyperpolarization that controls self activity.
Salma A, Quraishi, Carlos A, Paladini
openaire   +2 more sources

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

Frontiers in Pharmacology, 2022
Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach, Zachary W. Reichenbach, Kelly DiMattio, Suren Rajakaruna, David Ambrose, William D. Cornwell, Ronald J. Tallarida, Thomas Rogers, Lee-Yuan Liu-Chen, Ronald F. Tuma, Sara Jane Ward   +10 more
doaj   +1 more source

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Alzheimer’s Research & Therapy, 2021
Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro   +7 more
doaj   +1 more source

The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in App^NL-G-F Knock-In Mice

Biology, 2023
Background: The endocannabinoid system (ECS) and associated lipid transmitter-based signaling systems play an important role in modulating brain neuroinflammation. ECS is affected in neurodegenerative disorders, such as Alzheimer’s disease (AD).
Dina Medina-Vera, Hongjing Zhao, Erika Bereczki, Cristina Rosell-Valle, Makoto Shimozawa, Gefei Chen, Fernando Rodríguez de Fonseca, Per Nilsson, Simone Tambaro   +8 more
doaj   +1 more source

Impact of the Endocannabinoid System on Bone Formation and Remodeling in p62 KO Mice

Frontiers in Pharmacology, 2022
Several studies have shown that the G-protein coupled cannabinoid receptor CB2 and its interaction partner p62 are molecularly involved in bone remodeling processes.
Christina Keller, Timur Alexander Yorgan, Sebastian Rading, Thorsten Schinke, Meliha Karsak   +4 more
doaj   +1 more source