Results 11 to 20 of about 644 (148)

Brain CB2 Receptors: Implications for Neuropsychiatric Disorders

Pharmaceuticals, 2010
Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB2 receptor in the brain
Michelle Roche, David P Finn
doaj   +1 more source

β-caryophyllene, an FDA-Approved Food Additive, Inhibits Methamphetamine-Taking and Methamphetamine-Seeking Behaviors Possibly via CB2 and Non-CB2 Receptor Mechanisms

Frontiers in Pharmacology, 2021
Recent research indicates that brain cannabinoid CB2 receptors are involved in drug reward and addiction. However, it is unclear whether β-caryophyllene (BCP), a natural product with a CB2 receptor agonist profile, has therapeutic effects on ...
Xiang-Hu He, Xiang-Hu He, Ewa Galaj, Guo-Hua Bi, Yi He, Briana Hempel, Yan-Lin Wang, Eliot L. Gardner, Zheng-Xiong Xi   +8 more
doaj   +1 more source

Upregulation of CB2 receptors in reactive astrocytes in canine degenerative myelopathy, a disease model of amyotrophic lateral sclerosis

Disease Models & Mechanisms, 2017
Targeting of the CB2 receptor results in neuroprotection in the SOD1G93A mutant mouse model of amyotrophic lateral sclerosis (ALS). The neuroprotective effects of CB2 receptors are facilitated by their upregulation in the spinal cord of the mutant mice ...
María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R. Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz   +6 more
doaj   +1 more source

Pharmacological blockade of cannabinoid receptor 2 signaling does not affect LPS/IFN-γ-induced microglial activation

Scientific Reports, 2023
Cannabinoid receptor 2 (CB2) signaling modulates microglial responses to inflammatory stimuli. Our previous studies demonstrated that genetic deletion of CB2 inhibits microglial activation during inflammatory stimulation of toll-like receptors (TLRs) or ...
Bolanle Fatimat Olabiyi, Anne-Caroline Schmoele, Eva Carolina Beins, Andreas Zimmer   +3 more
doaj   +1 more source

The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain. [PDF]

PLoS ONE, 2013
The major effects of cannabinoids and endocannabinoids are mediated via two G protein-coupled receptors, CB1 and CB2, elucidation of the mechanism and structural determinants of the CB2 receptor coupling with G proteins will have a significant impact on ...
Congxia Zheng, Linjie Chen, Xiaopan Chen, Xiaobai He, Jingwen Yang, Ying Shi, Naiming Zhou   +6 more
doaj   +1 more source

METHODS FOR RECOMBINANT EXPRESSION AND FUNCTIONAL CHARACTERIZATION OF HUMAN CANNABINOID RECEPTOR CB2

Computational and Structural Biotechnology Journal, 2013
Cannabinoid receptor CB2 is a seven transmembrane-domain integral membrane protein that belongs to a large superfamily of G protein-coupled receptors (GPCR).
Alexei A. Yeliseev
doaj   +1 more source

CB2 receptor antibody signal specificity: correlations with the use of partial CB2-knockout mice and anti-rat CB2 receptor antibodies [PDF]

Acta Pharmacologica Sinica, 2018
Cannabinoid CB1 receptors are highly expressed in the brain and functionally modulate presynaptic neurotransmitter release, while cannabinoid CB2 receptors (CB2Rs) were initially identified in the spleen and regarded as peripheral cannabinoid receptors. Recently, growing evidence indicates the presence of functional CB2Rs in the brain.
Hai-Ying, Zhang, Hui, Shen, Chloe J, Jordan, Qing-Rong, Liu, Eliot L, Gardner, Antonello, Bonci, Zheng-Xiong, Xi   +6 more
openaire   +2 more sources

Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor

Molecules, 2023
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2 ...
Claudia Mugnaini, Magdalena Kostrzewa, Marta Casini, Poulami Kumar, Valeria Catallo, Marco Allarà, Laura Guastaferro, Antonella Brizzi, Marco Paolino, Andrea Tafi, Christelos Kapatais, Gianluca Giorgi, Federica Vacondio, Marco Mor, Federico Corelli, Alessia Ligresti   +15 more
doaj   +1 more source

CB2 Cannabinoid Receptor Knockout in Mice Impairs Contextual Long-Term Memory and Enhances Spatial Working Memory

Neural Plasticity, 2016
Neurocognitive effects of cannabinoids have been extensively studied with a focus on CB1 cannabinoid receptors because CB1 receptors have been considered the major cannabinoid receptor in the nervous system. However, recent discoveries of CB2 cannabinoid
Yong Li, Jimok Kim
doaj   +1 more source

Electroacupuncture Reduces Visceral Pain Via Cannabinoid CB2 Receptors in a Mouse Model of Inflammatory Bowel Disease

Frontiers in Pharmacology, 2022
Inflammatory bowel disease (IBD) results in chronic abdominal pain in patients due to the presence of inflammatory responses in the colon. Electroacupuncture (EA) is effective in alleviating visceral pain and colonic inflammation associated with IBD ...
Hong Zhang, Wei He, Xue-Fei Hu, Yan-Zhen Li, Yong-Min Liu, Wen-Qiang Ge, Ou-Yang Zhanmu, Chao Chen, Yu-Ye Lan, Yang-Shuai Su, Xiang-Hong Jing, Bing Zhu, Hui-Lin Pan, Ling-Ling Yu, Man Li   +14 more
doaj   +1 more source