Results 101 to 110 of about 644 (148)
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Mini-Reviews in Medicinal Chemistry, 2005
The CB(1) receptor is found principally in the central nervous system and is responsible for the overt physiological effects of cannabinoids. In contrast, the CB(2) receptor is expressed primarily in the immune system and is responsible for few, if any, obvious behavioral effects.
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The CB(1) receptor is found principally in the central nervous system and is responsible for the overt physiological effects of cannabinoids. In contrast, the CB(2) receptor is expressed primarily in the immune system and is responsible for few, if any, obvious behavioral effects.
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CB2 cannabinoid receptor mediation of antinociception
Acute Pain, 2006Management of acute pain remains a significant clinical problem. In preclinical studies, CB2 cannabinoid receptor-selective agonists inhibit nociception without producing central nervous system side effects. The CB2 receptor-selective agonist AM1241 produces antinociceptive effects that are antagonized by CB2, but not CB1, receptor-selective ...
Mohab M, Ibrahim +9 more
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Pharmacology of cannabinoid CB1 and CB2 receptors
Pharmacology & Therapeutics, 1997There are at least two types of cannabinoid receptors, CB1 and CB2, both coupled to G-proteins. CB1 receptors are present in the central nervous system and CB1 and CB2 receptors in certain peripheral tissues. The existence of endogenous cannabinoid receptor agonists has also been demonstrated.
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2021
CB2 receptor was once considered to be the “peripheral cannabinoid receptor.” This label was based on its discovery and abundant expression in the immune system and, until recently, absence from the central nervous system. It is now accepted that CB2 receptors are expressed in the central nervous system as well. CB2 receptors have been expressed in the
Glenn R. Rech, Samer N. Narouze
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CB2 receptor was once considered to be the “peripheral cannabinoid receptor.” This label was based on its discovery and abundant expression in the immune system and, until recently, absence from the central nervous system. It is now accepted that CB2 receptors are expressed in the central nervous system as well. CB2 receptors have been expressed in the
Glenn R. Rech, Samer N. Narouze
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The Search for Selective Ligands for the CB2 Receptor
Current Pharmaceutical Design, 2000Following the identification of the CB2 receptor several groups explored the development of selective ligands for this receptor which occurs principally in the periphery. This led to the discovery that two cannabimimetic indoles, 1-(2, 3-dichlorobenzoyl)-2-methyl-3-(2-[1-morpholino]ethyl)-5-methoxyind ole (L768242) and 2-methyl-1-propyl-3-(1-naphthoyl ...
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Activation of CB2 Receptors by (−)-Cannabichromene but Not (+)-Cannabichromene
Cannabis & Cannabinoid ResearchIntroduction: Cannabichromene (CBC) is a minor constituent of cannabis that is a selective cannabinoid CB2 receptor agonist and activator of TRPA1. To date, it has not been shown whether (−)-CBC, (+)-CBC, or both can mediate these effects.
Michael Udoh +6 more
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Cannabinoid CB1 and CB2 Receptor Ligand Specificity and the Development of CB2-Selective Agonists
Current Medicinal Chemistry, 2008Cannabinoids in current use such as nabilone activate both CB1 and CB2 receptors. Selective CB2 activation may provide some of the therapeutic effects of cannabinoids, such as their immuno-modulatory properties, without the psychoactive effects of CB1 activation.
John C, Ashton +3 more
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Current Medicinal Chemistry, 2007
This review gives a brief overview of the expression patterns, molecular pharmacology and physiological role of the cannabinoid 2 receptor (CB2) in pain. Particular emphasis is given to the therapeutic utility of CB2 receptor agonists. Through studies utilizing selective CB2 receptor agonists, non-selective cannabinoid agonists in conjunction with ...
G T, Whiteside, G P, Lee, K J, Valenzano
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This review gives a brief overview of the expression patterns, molecular pharmacology and physiological role of the cannabinoid 2 receptor (CB2) in pain. Particular emphasis is given to the therapeutic utility of CB2 receptor agonists. Through studies utilizing selective CB2 receptor agonists, non-selective cannabinoid agonists in conjunction with ...
G T, Whiteside, G P, Lee, K J, Valenzano
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Targeting the Cannabinoid CB2 Receptor: Mutations, Modeling and Development of CB2 Selective Ligands
Current Medicinal Chemistry, 2005Since the discovery of the cannabinoid CB2 receptor in 1993, there has been a growing interest to clarify the importance of this G-protein coupled receptor (GPCR) for human physiology, and to investigate it as a possible target for current and future drug development.
K H, Raitio +4 more
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Antifibrogenic role of the cannabinoid receptor CB2 in the liver
Gastroenterology, 2005Hepatic myofibroblasts are central for the development of liver fibrosis associated with chronic liver diseases, and blocking their accumulation may prevent fibrogenesis. Cannabinoids are the active components of marijuana and act via 2 G-protein-coupled receptors, CB1 and CB2.
Boris, Julien +8 more
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