Results 51 to 60 of about 4,301 (202)

Development of multivalent vaccine targeting M segment of Crimean Congo Hemorrhagic Fever Virus (CCHFV) using immunoinformatic approaches

Saudi Journal of Biological Sciences, 2022
Crimean-Congo Hemorrhagic Fever (CCHF) is a tick-borne viral infection with no licensed vaccine or therapeutics available for its treatment. In the present study we have developed the first multi-epitope subunit vaccine effective against all the seven genotypes of CCHF virus (CCHFV).
Sana, Maaza, Javed, Aneela, Babar Jamal, Syed, Junaid, Muhammad, Faheem, Muhammad   +4 more
openaire   +2 more sources

Unveiling the threat: Balochistan's path to congo virus endemicity

Journal of the Pakistan Medical Association
Dear Madam, The detection of 16 cases of Crimean Congo Haemorrhagic Fever Virus (CCHFV) in the Balochistan province this year (1) and a 2020 study indicating a seroprevalence of 2.7% in humans and 36.2% in livestock in Pakistan, with Balochistan ...
Rida Irfan, Noor Ul Huda, Maryum Imran, Javeria Kamran   +3 more
doaj   +1 more source

The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly

Emerging Microbes & Infections
The Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus that causes high mortality in humans. This enveloped virus harbors two surface glycoproteins (GP), Gn and Gc, that are released by processing of a glycoprotein precursor complex whose maturation takes place in the ER and is completed through the secretion pathway.
Gautam, Anupriya, Lalande, Alexandre, Ritter, Maureen, Freitas, Natalia, Lerolle, Solène, Canus, Lola, Amirache, Fouzia, Lotteau, Vincent, Legros, Vincent, Cosset, François-Loïc, Mathieu, Cyrille, Boson, Bertrand   +11 more
openaire   +4 more sources

Planning for the unexpected: Ebola virus, Zika virus, what's next? [PDF]

, 2016
Since 2000 we have witnessed global pandemics and public health emergencies of international concern. This review details which viruses are likely to caused further outbreaks and looks at the strategies and tools available to UK medical professionals to ...
Welfare, W., Welfare, W., Wright, E., Wright, E.   +3 more
core   +3 more sources

First Whole Genome Sequencing of Crimean–Congo Hemorrhagic Fever Virus (CCHFV) in Tick Species within Ghana

Transboundary and Emerging Diseases, 2023
Crimean–Congo hemorrhagic fever (CCHF) is a serious viral zoonotic disease spread by ticks and caused by the Crimean–Congo hemorrhagic fever virus (CCHFV). The emergence and reemergence of CCHF in various nations in the Eastern Mediterranean Region over the last decade have shown a growing risk of the disease spreading to new areas, especially in ...
Ronald Essah Bentil, Seth Offei Addo, Mba-tihssommah Mosore, Selassie Kumordjie, Clara Yeboah, Bright Agbodzi, Eric Behene, Janice Tagoe, Bernice Olivia Ama Baako, Victor Asoala, Richard Osei Ampadu, Daniel Lartei Mingle, Edward O. Nyarko, Anne T. Fox, Andrew G. Letizia, Joseph William Diclaro, Terrel Sanders, Daniel Oduro, Shirley C. Nimo-Paintsil, James Harwood, Samuel Kweku Dadzie   +20 more
openaire   +2 more sources

Molecular Analysis of Crimean-Congo Hemorrhagic Fever Virus Among Fatal and Non-fatal Cases in Tokat Province

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2019
Objectives:Crimean-Congo hemorrhagic fever (CCHF) is seen in our country with fatality rate of 5% since 2002. It was aimed to reveal if there were any differences responsible from fatalities in M segments of CCHF viruses detected in patients’ sera in ...
Dilek Yağcı Çağlayık, Fatma Bayrakdar   +1 more
doaj   +1 more source

Purification of Crimean Congo Hemorrhagic Fever Virus (CCHFV) Nucleocapsid Protein Using Detergent Gradient and Free Thawing

BIO-PROTOCOL, 2022
Protein aggregation remains a major challenge in the purification of recombinant proteins in both eukaryotic and prokaryotic expression systems. One such protein is the nucleocapsid protein of Crimean Congo Hemorrhagic fever virus (CCHFV), which has high aggregation tendency and rapidly precipitates upon purification by NiNTA chromatography.
Austin Royster, Sheema Mir
openaire   +3 more sources

Bunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase [PDF]

, 2016
This study was supported by Wellcome Trust Grant 099220/B/12/Z (to R.M.E.) and Grant 094476/Z/10/Z that funded the purchase of the TripleTOF 5600 mass spectrometer at the Biomedical Sciences Research Complex (BSRC) of University of St. Andrews.Bunyamwera
Botting, Catherine Helen, Brennan, Benjamin, Elliott, Richard Michael, Li, Ping, Niglas, Mark, Shi, Xiaohong, Shirran, Sally Lorna, Szemiel, Agnieszka Marta   +7 more
core   +2 more sources

Lung Volume and Density Assessment in Crimean–Congo Hemorrhagic Fever Patients: Correlations With SGS

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Crimean–Congo hemorrhagic fever (CCHF) is a viral disease that can cause multiorgan failure and death, yet its pulmonary involvement remains poorly understood. This retrospective study included 107 patients diagnosed with CCHF and evaluated the relationship between lung volume and density changes on computed tomography (CT) and the Severity Grading ...
Nisa Baspinar, Seyit Ali Büyüktuna, Priya Gusain   +2 more
wiley   +1 more source

Sheep and Cattle Are Not Susceptible to Experimental Inoculation with Hazara Orthonairovirus, a Tick-Borne Arbovirus Closely Related to CCHFV

Microorganisms, 2020
Hazara orthonairovirus (HAZV) is a tick-borne arbovirus closely related to Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV). Whereas CCHFV is a biosafety level (BSL) 4 agent, HAZV is classified as BSL 2, as it is not known to cause any disease in ...
Julia Hartlaub, Felicitas von Arnim, Christine Fast, Maryna Somova, Ali Mirazimi, Martin H. Groschup, Markus Keller   +6 more
doaj   +1 more source