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Blackcurrant anthocyanins modulate CCL11 secretion and suppress allergic airway inflammation

Molecular Nutrition and Food Research, 2017
CCL11, a chemokine, is linked to the early development of airways eosinophilia in allergic asthma. Therefore, CCL11 production is a target for abrogating eosinophilic-driven airway inflammation. Blackcurrants are high in compounds that regulate inflammation, particularly anthocyanins.
Odette M Shaw, Tafadzwa Nyanhanda, Tony K Mcghie   +2 more
exaly   +5 more sources

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Association of CCL11, CCL24 and CCL26 with primary biliary cholangitis

International Immunopharmacology, 2019
CCL11, CCL24 and CCL26 are potent chemokines for eosinophils. Since there has been no study reporting the association serum CCL11, CCL24 and CCL26 with fibrotic progression of PBC, the aim of this study is to explore the association.One hundred and eight PBC patients, 52 patients with chronic hepatitis B (CHB) and 50 healthy controls (HC) were ...
Renqian Zhong, Zaixing Yang
exaly   +3 more sources

Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus

Brain, Behavior, and Immunity, 2021
A deterioration in cognitive performance accompanies brain aging, even in the absence of neurodegenerative pathologies. However, the rate of cognitive decline can be slowed down by enhanced cognitive and sensorimotor stimulation protocols, such as environmental enrichment (EE).
Scabia G., Testa G., Scali M., Del Turco S., Desiato G., Berardi N., Sale A., Matteoli M., Maffei L., Maffei M., Mainardi M., Train the Brain Consortium   +11 more
openaire   +4 more sources

Decoding the roles of CCL11 in human malignancies and clinical implications

Biochemical Pharmacology
C-C motif chemokine ligand 11 (CCL11), alternatively designated as eotaxin-1, is a low molecular weight chemokine that plays a crucial role in the mediation of allergic inflammation and immune regulation. This is achieved through the recruitment of eosinophils, T helper 2 (Th2) cells, and basophils via its primary receptor, CC chemokine receptor 3 ...
Baocheng Zhou, Hongxing Shen
exaly   +3 more sources

Regulatory role and translational potential of CCL11 in liver fibrosis

Hepatology, 2023
Background and Aims: Myofibroblasts are considered the major effector cell type of liver fibrosis and primarily derived from hepatic stellate cells (HSCs). In the present study, we investigated the contribution of C-C motif chemokine (CCL11) to HSC-myofibroblast trans-differentiation and its implication in liver fibrosis.
Ming Kong, Wenhui Dong, Aoqi Kang, Yameng Kuai, Tongchang Xu, Zhiwen Fan, Longqing Shi, Donglin Sun, Yunjie Lu, Zilong Li, Yong Xu   +10 more
openaire   +2 more sources

CCL11 exacerbates colitis and inflammation-associated colon tumorigenesis

Oncogene, 2021
CCL11, also known as eotaxin-1, is described as an eosinophil chemoattractant, which has been implicated in allergic and Th2 inflammatory diseases. We have reported that CCL11 is significantly increased in the serum of inflammatory bowel disease (IBD) patients, colonic eosinophils are increased and correlate with tissue CCL11 levels in ulcerative ...
Dina Polosukhina, Kshipra Singh, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Dana M. Hardbower, M. Blanca Piazuelo, M. Kay Washington, Alain P. Gobert, Keith T. Wilson, Lori A. Coburn   +10 more
openaire   +3 more sources

The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts

Journal of Allergy and Clinical Immunology, 2006
BACKGROUND: Eotaxin/CCL11 plays an important role in asthma. It acts through the chemokine receptor CCR3 expressed on hematopoietic and nonhematopoietic cells in the lung.
Ilaria Puxeddu, R Reich, F Levischaffer   +2 more
exaly   +2 more sources

Targeting CCL11 in the treatment of ovarian cancer

Expert Opinion on Therapeutic Targets, 2010
The chemokine network, comprised of mediators of inflammation, has been implicated in the development of a number of human cancers. The eosinophil chemoattractant CCL11 was recently shown to play a role in the development of ovarian cancer. Here we review findings regarding CCL11 and discuss its use as a target in the treatment of ovarian cancer.We ...
Brian M, Nolen, Anna E, Lokshin
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CCL11 as a potential diagnostic marker for asthma?

Journal of Asthma, 2014
Asthma is an inflammatory airway disease characterized by airway eosinophilia, in which CCL11 (eotaxin) plays a crucial role. The aim of study is to determine the elevation of CCL11 levels in bronchoalveolar lavage fluid (BALF), blood, exhaled breath condensate (EBC) and sputum in asthma patients and to identify which medium yields the most significant
Dandan, Wu, Ji, Zhou, Hui, Bi, Lingling, Li, Wei, Gao, Mao, Huang, Ian M, Adcock, Peter J, Barnes, Xin, Yao   +8 more
openaire   +2 more sources

Increased serum levels of CCL11/eotaxin in schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2008
Inflammatory and immune alterations occur and may be relevant in patients with schizophrenia. Chemokines are a subgroup of cytokines that play a major role in the recruitment of determined subsets of leukocytes into tissues. To date no study has evaluated whether levels of chemokines are altered in patients with schizophrenia.To evaluate serum levels ...
Antonio Lucio, Teixeira, Helton Jose, Reis, Rodrigo, Nicolato, Gustavo, Brito-Melo, Humberto, Correa, Mauro Martins, Teixeira, Marco Aurelio, Romano-Silva   +6 more
openaire   +2 more sources