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Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4
Expert Opinion on Drug Discovery, 2014The chemokine receptors CCR3 and CCR4 have been shown to be important therapeutic targets for the treatment of a variety of diseases. Although only two chemokine receptor inhibitors have been approved so far, there are numerous compounds that are in various stages of development.In this review article, the authors provide an update on the progress made
James E Pease, Richard Horuk
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A single nucleotide polymorphism in the CCR3 gene ablates receptor export to the plasma membrane
Journal of Allergy and Clinical Immunology, 2010The chemokine receptor CCR3 orchestrates the migration of eosinophils, basophils, T(H)2 lymphocytes, and mast cells during the allergic response, with CCR3 blockade a potential means of therapeutic intervention. Non-synonymous single nucleotide polymorphisms (SNPs) within the ccr3 gene have previously been described, with little information regarding ...
Timothy J Williams, James E Pease
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Retinoic acids up‐regulate functional eosinophil‐driving receptor CCR3
Allergy: European Journal of Allergy and Clinical Immunology, 2013Shigeharu Ueki +2 more
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Identification of a Potent and Nonpeptidyl CCR3 Antagonist
Biochemical and Biophysical Research Communications, 2001Toshihiko Saeki +2 more
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Distribution of CCR3 mRNA expression in horse tissues
Veterinary Immunology and Immunopathology, 2006Fiona M Cunningham
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The function of CCR3 on mouse bone marrow‐derived mast cells in vitro
Immunology, 2010John Westwick, Timothy J Williams
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Pyrrolidinohydroquinazolines––a novel class of CCR3 modulators
Bioorganic and Medicinal Chemistry Letters, 2005exaly
Enhanced Expression of Eotaxin and CCR3 in Atopic Dermatitis
Journal of Investigative Dermatology, 1999Nikhil Yawalkar +2 more
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