Results 11 to 20 of about 7,919 (172)

Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD

Cell Reports, 2023
Summary: Melatonin has been reported to improve nonalcoholic fatty liver disease (NAFLD), and exploring the underlying mechanisms will be beneficial for better treatment of NAFLD.
Yushang Zhao, Xiaonan Du, Dong Zhang
exaly   +3 more sources

In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3 [PDF]

Membranes, 2021
CC motif chemokine receptor 3 (CCR3) is a Class A G protein-coupled receptor (GPCR) mainly responsible for the cellular trafficking of eosinophils. As such, it plays key roles in inflammatory conditions, such as asthma and arthritis, and the metastasis ...
Evan van Aalst, Jotham Koneri, Benjamin J. Wylie   +2 more
doaj   +3 more sources

Functional expression of CCL8 and its interaction with chemokine receptor CCR3 [PDF]

BMC Immunology, 2017
Background Chemokines and their cognate receptors play important role in the control of leukocyte chemotaxis, HIV entry and other inflammatory diseases.
Baosheng Ge, Jiqiang Li, Zhijin Wei, Tingting Sun, Yanzhuo Song, Naseer Ullah Khan   +5 more
doaj   +3 more sources

Peripheral lncRNA-IL1RAP Dysregulation in Schizophrenia: A Multi-Omics Bridge Between Immunity and Diagnosis. [PDF]

Brain Behav
Bulk RNA‐seq of PBL from first‐episode or unmedicated SCZ patients identifies an opposite‐direction two‐lncRNA signal at the CCR3 and IL1RAP loci, supported by qRT–PCR and yielding strong internal but uncertain external discrimination. Immune‐linked programs recurrently involve IL1RAP/IL‐1 branches and map, in a healthy‐donor PBMC single‐cell reference,
Wu J, Niu R, Liu Z, Li Y, Zhang Y, Teng Z, Zeng Y, Bao T.   +7 more
europepmc   +2 more sources

Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3

Cell Discovery, 2022
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present cryo-electron microscopy structures of two human CC chemokine receptor–G-protein complexes: CCR2 bound to ...
Zhehua Shao, Yangxia Tan, Qingya Shen, Li Hou, Bingpeng Yao, Jiao Qin, Peiyu Xu, Chunyou Mao, Li-Nan Chen, Huibing Zhang, Dan-Dan Shen, Chao Zhang, Weijie Li, Xufei Du, Fei Li, Zhi-Hua Chen, Yi Jiang, H. Eric Xu, Songmin Ying, Honglei Ma, Yan Zhang, Huahao Shen   +21 more
doaj   +3 more sources

Inflammatory Mediators of Alzheimer’s Disease Characterized in a Mouse Model (APP/PS1) [PDF]

NeuroSci
Alzheimer’s disease (AD) is marked by amyloid plaques, hyperphosphorylated TAU proteins, and neuroinflammation. The APP/PS1 mouse model is widely used to study AD pathogenesis.
Adrian Jorda, Kenia Alvarez-Gamez, Ignacio Campo-Palacio, Juan Campos-Campos, Carlos Colmena, Sandeep Kumar Singh, Maria Jose Chiva Miralles, Constanza Aldasoro, Martin Aldasoro, Soraya L. Valles   +9 more
doaj   +2 more sources

Basophil FCER1A and PTAFR Gene Expression Profiles Correlate With Disease Severity in Chronic Spontaneous Urticaria. [PDF]

Clin Transl Allergy
ABSTRACT Background Chronic Spontaneous Urticaria (CSU) is a debilitating skin condition characterized by recurrent wheals and pruritus, significantly impacting quality of life. Molecular mechanisms underlying different severity phenotypes are not fully understood.
Soetanto KM, Sripatumtong C, Paringkarn T, Angkoolpakdeekul N, Kulthanan K, Srinoulprasert Y.   +5 more
europepmc   +2 more sources

Antagonist of chemokine receptors CCR1 and CCR3 [PDF]

Respiratory Research, 2000
Ammit Alaina, Sabroe I, Peck MJ, Van Keulen BJ, Jorritsma A, Simmons G, Clapham PR, Williams TJ, Pease JE   +8 more
doaj   +2 more sources

Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells [PDF]

Journal of Leukocyte Biology, 2000
Abstract A novel pharmacological study of CCR3 receptor reserve in a CCR3-transfected cell (CREM3) and human eosinophils was done; functional responses measured were increases in intracellular calcium and chemotaxis. Eotaxin, eotaxin-2, monocyte chemoattractant protein-4 (MCP-4), RANTES, and MCP-3 induced similar maximal eosinophil ...
S P, Umland, Y, Wan, J, Shortall, H, Shah, J, Jakway, C G, Garlisi, F, Tian, R W, Egan, M M, Billah   +8 more
openaire   +2 more sources

Chemokine Receptors—Structure-Based Virtual Screening Assisted by Machine Learning

Pharmaceutics, 2023
Chemokines modulate the immune response by regulating the migration of immune cells. They are also known to participate in such processes as cell–cell adhesion, allograft rejection, and angiogenesis.
Paulina Dragan, Matthew Merski, Szymon Wiśniewski, Swapnil Ganesh Sanmukh, Dorota Latek   +4 more
doaj   +1 more source