Results 21 to 30 of about 7,919 (172)

Identification and Characterization of Novel Antagonists of the CCR3 Receptor [PDF]

SLAS Discovery, 2003
Eotaxin, an inducer of eosinophil migration and activation, exerts its activity by binding to CCR3, the C-C chemokine receptor 3. An inhibitor of the eotaxin-CCR3 binding interaction may have potential as an anti-inflammatory drug for treatment of asthma, parasitic infections, and allergic disorders.
Usha, Warrior, Evelyn M, McKeegan, Susan M, Rottinghaus, Lora, Garcia, Linda, Traphagen, George, Grayson, Victoria, Komater, Teresa, McNally, Rosalind, Helfrich, Richard R, Harris, Randy L, Bell, David J, Burns   +11 more
openaire   +2 more sources

Chemokine Receptor CCR3 Expression in Malignant Cutaneous Tumors [PDF]

Annals of Dermatology, 2010
Chemokines and their receptors are important players in tumorigenesis by facilitating tumor proliferation and metastasis. Little is known about the possible function of chemokine receptors in relation to the development and progression of malignant cutaneous tumors.The aim of this study was to determine the chemokine receptor CCR3 expression pattern ...
Yoon-Jin, Lee, Dae-Hyun, Kim, Sang-Han, Lee, Hae-Seon, Nam, Mi Ryung, Roh, Moon-Kyun, Cho   +5 more
openaire   +2 more sources

Chemokine receptors differentially expressed by race category and molecular subtype in the breast cancer TCGA cohort

Scientific Reports, 2022
Racial disparities in mortality due to metastasis remain significant among breast cancer patients. Chemokine receptors contribute to breast tumors and metastatic outcome.
Elissa D. Vazquez, Xiangyi Fang, Lauren A. Levesque, Mike Huynh, Citlali Venegas, Nhien Lu, Nicole Salazar   +6 more
doaj   +1 more source

Investigation into imbalance of Th1/Th2 cells in cirrhotic, hypersplenic rats

Journal of International Medical Research, 2020
Objectives To evaluate the Th1/Th2 cell profile in spleens of cirrhotic and hypersplenic rats by investigating the expression of Th1-associated chemokine receptors CXCR3, CCR5 and Th2-associated chemokine receptor CCR3.
Yunfu Lv, Yejuan Li, Ning Liu, Yonghong Dong, Jie Deng   +4 more
doaj   +1 more source

Immunohistochemical Study of Some Chemokines Receptors in Atopic Epidermis: Before and After Treatment with Topical Tacrolimus–steroid Therapy

The Iraqi Journal of Medical Sciences, 2016
Background: Tacrolimus is an immunosuppressive agent used topically, it has been found to be effective in treating moderate to severe atopic dermatitis without causing the atrophy that might occur with prolonged use of topical corticosteroids.
Nidhal AM Mohammed, Ahmad H. Muhana
doaj   +6 more sources

Functional Analysis of the Chemokine Receptor CCR3 on Airway Epithelial Cells [PDF]

The Journal of Immunology, 2006
Abstract The function of chemokine receptors on structural cells is only partially known. We previously reported the expression of a functional CCR3 receptor on airway epithelial cells (EC). We speculated that CCR3 might drive wound repair and expression of inflammatory genes in epithelium.
Beck LA, Tancowny B, Brummet ME, Asaki SY, Curry SL, Penno MB, Foster M, Bahl A, STELLATO, Cristiana   +8 more
openaire   +3 more sources

New variations of human CC-chemokine receptors CCR3 and CCR4 [PDF]

Genes & Immunity, 1999
CCR3 and CCR4 are the members of CC chemokine receptor family expressed on Th2 type CD4+ T cells. In this study, variation screening of the entire coding regions of CCR3 and CCR4 was performed, and possible association with several autoimmune diseases was tested, using the genomic DNA from 304 Japanese healthy individuals and 272 Japanese patients with
H, Kato, N, Tsuchiya, S, Izumi, M, Miyamasu, T, Nakajima, H, Kawasaki, K, Hirai, K, Tokunaga   +7 more
openaire   +2 more sources

CCL18 exhibits a regulatory role through inhibition of receptor and glycosaminoglycan binding. [PDF]

PLoS ONE, 2013
CCL18 has been reported to be present constitutively at high levels in the circulation, and is further elevated during inflammatory diseases. Since it is a rather poor chemoattractant, we wondered if it may have a regulatory role. CCL18 has been reported
Sonja C Krohn, Pauline Bonvin, Amanda E I Proudfoot   +2 more
doaj   +1 more source

Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling

Frontiers in Molecular Biosciences, 2021
Cholesterol as an allosteric modulator of G protein-coupled receptor (GPCR) function is well documented. This quintessential mammalian lipid facilitates receptor–ligand interactions and multimerization states.
Evan van Aalst, Benjamin J. Wylie
doaj   +1 more source

Tryptase-Chymase Double-Positive Human Mast Cells Express the Eotaxin Receptor CCR3 and Are Attracted by CCR3-Binding Chemokines [PDF]

The American Journal of Pathology, 1999
Eosinophils, basophils, and Th2 cells express the chemokine receptor CCR3, which binds eotaxin, RANTES, and some other chemokines. Using immunohistochemistry and flow cytometry, we demonstrate that CCR3 is also expressed by a variable proportion of human mast cells in gut, skin, and lung tissue.
ROMAGNANI, PAOLA, A. DE PAOLIS, C. BELTRAME, ANNUNZIATO, FRANCESCO, V. DENTE, MAGGI, ENRICO, ROMAGNANI, SERGIO, G. MARONE   +7 more
openaire   +5 more sources