Results 1 to 10 of about 22,866 (205)

CCR3 and choroidal neovascularization. [PDF]

PLoS ONE, 2011
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacularization (CNV), could result in rapid and severe loss ...
Yiwen Li, Deqiang Huang, Xin Xia, Zhengying Wang, Lingyu Luo, Rong Wen   +5 more
doaj   +5 more sources

Narcolepsy susceptibility gene CCR3 modulates sleep-wake patterns in mice. [PDF]

PLoS ONE, 2017
Narcolepsy is caused by the loss of hypocretin (Hcrt) neurons and is associated with multiple genetic and environmental factors. Although abnormalities in immunity are suggested to be involved in the etiology of narcolepsy, no decisive mechanism has been
Hiromi Toyoda, Yoshiko Honda, Susumu Tanaka, Taku Miyagawa, Makoto Honda, Kazuki Honda, Katsushi Tokunaga, Tohru Kodama   +7 more
doaj   +2 more sources

Receptor reserve analysis of the human CCR3 receptor in eosinophils and CCR3-transfected cells [PDF]

Journal of Leukocyte Biology, 2000
Abstract A novel pharmacological study of CCR3 receptor reserve in a CCR3-transfected cell (CREM3) and human eosinophils was done; functional responses measured were increases in intracellular calcium and chemotaxis. Eotaxin, eotaxin-2, monocyte chemoattractant protein-4 (MCP-4), RANTES, and MCP-3 induced similar maximal eosinophil ...
S P, Umland, Y, Wan, J, Shortall, H, Shah, J, Jakway, C G, Garlisi, F, Tian, R W, Egan, M M, Billah   +8 more
openaire   +3 more sources

Retinal Inhibition of CCR3 Induces Retinal Cell Death in a Murine Model of Choroidal Neovascularization. [PDF]

PLoS ONE, 2016
Inhibition of chemokine C-C motif receptor 3 (CCR3) signaling has been considered as treatment for neovascular age-related macular degeneration (AMD). However, CCR3 is expressed in neural retina from aged human donor eyes.
Haibo Wang, Xiaokun Han, Deeksha Gambhir, Silke Becker, Eric Kunz, Angelina Jingtong Liu, M Elizabeth Hartnett   +6 more
doaj   +2 more sources

Rebalancing liver-infiltrating CCR3+ and CD206+ monocytes improves diet-induced NAFLD

Cell Reports, 2023
Summary: Melatonin has been reported to improve nonalcoholic fatty liver disease (NAFLD), and exploring the underlying mechanisms will be beneficial for better treatment of NAFLD.
Yushang Zhao, Xiaonan Du, Dong Zhang
exaly   +3 more sources

CpG methylation at GATA elements in the regulatory region ofCCR3positively correlates withCCR3transcription [PDF]

Experimental & Molecular Medicine, 2012
DNA methylation may regulate gene expression by restricting the access of transcription factors. We have previously demonstrated that GATA-1 regulates the transcription of the CCR3 gene by dynamically interacting with both positively and negatively acting GATA elements of high affinity binding in the proximal promoter region including exon 1.
Uhm, Tae Gi, Lee, Seol Kyung, Kim, Byung Soo, Kang, Jin Hyun, Park, Choon-Sik, Rhim, Tai Youn, Chang, Hun Soo, Kim, Do-Jin, Chung, Il Yup   +8 more
openaire   +3 more sources

Epitope Mapping of Anti-Mouse CCR3 Monoclonal Antibodies Using Flow Cytometry

Antibodies, 2022
The CC chemokine receptor 3 (CCR3) is a receptor for CC chemokines, including CCL5/RANTES, CCL7/MCP-3, and CCL11/eotaxin. CCR3 is expressed on the surface of eosinophils, basophils, a subset of Th2 lymphocytes, mast cells, and airway epithelial cells ...
Nami Tateyama, Teizo Asano, Hiroyuki Suzuki, Guanjie Li, Takeo Yoshikawa, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato   +7 more
doaj   +2 more sources

Peripheral lncRNA-IL1RAP Dysregulation in Schizophrenia: A Multi-Omics Bridge Between Immunity and Diagnosis. [PDF]

Brain Behav
Bulk RNA‐seq of PBL from first‐episode or unmedicated SCZ patients identifies an opposite‐direction two‐lncRNA signal at the CCR3 and IL1RAP loci, supported by qRT–PCR and yielding strong internal but uncertain external discrimination. Immune‐linked programs recurrently involve IL1RAP/IL‐1 branches and map, in a healthy‐donor PBMC single‐cell reference,
Wu J, Niu R, Liu Z, Li Y, Zhang Y, Teng Z, Zeng Y, Bao T.   +7 more
europepmc   +2 more sources

Roles of RUNX1 and PU.1 inCCR3Transcription [PDF]

Immune Network, 2016
CCR3 is a chemokine receptor that mediates the accumulation of allergic inflammatory cells, including eosinophils and Th2 cells, at inflamed sites. The regulatory sequence of the CCR3 gene, contains two Runt-related transcription factor (RUNX) 1 sites and two PU.1 sites, in addition to a functional GATA site for transactivation of the CCR3 gene. In the
Kong, Su-Kang, Kim, Byung Soo, Hwang, Sae Mi, Lee, Hyune Hwan, Chung, Il Yup   +4 more
openaire   +4 more sources

Chemokine receptor CCR3 is important for migration of mast cells in neurofibroma

Dermatologica Sinica, 2010
Background: Neurofibroma consists of abundant extracellular matrix and many types of cells, including Schwann cells (SCs), mast cells (MCs), fibroblasts and endothelial cells.
Wei-Chun Tai, Sin-Ting Wang, Chieh-Shan Wu, Tze-Yi Lin, Meng-Tse Wu   +4 more
doaj   +3 more sources