Results 21 to 30 of about 22,866 (205)

Chemokine CCL7 mediates trigeminal neuropathic pain CCR2/CCR3-ERK pathway in the trigeminal ganglion of mice

Molecular Pain, 2023
Background Chemokine-mediated neuroinflammation plays an important role in the pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor CCR2 have been reported to contribute to neuropathic pain via astrocyte-microglial ...
Lin-Peng Zhu, Meng-Lin Xu, Bao-Tong Yuan, Ling-Jie Ma, Yong-Jing Gao   +4 more
doaj   +1 more source

Effects of NB-UVB with pimecrolimus cream on the expression of eotaxin in serum and CCR3 on peripheral blood monocytes in patients with adult atopic dermatitis

Pifu-xingbing zhenliaoxue zazhi, 2020
Objective: To compare expression levels of eotaxin in the serum and CCR3 on the peripheral blood monocytes (PBMC) prior to and after the treatment with NB-UVB plus pimecrolimus cream, in order to elucidate the pathogenesis of atopic dermatitis(AD ...
Yan YANG, Jia-yan LI, Xin ZHOU, Xin TIAN, Ai-li GAO, Si-ying XIONG, Wei LI, Xiao-yin CHEN, Yu-mei LIU, Hui-lan ZHU   +9 more
doaj   +1 more source

Evaluation of CCR3 as a Basophil Activation Marker [PDF]

American Journal of Clinical Pathology, 2013
Recent reports have provided conflicting evidence on the stability of CCR3 expression on the surface of basophils. Hence we wanted to independently evaluate the diagnostic usefulness of CCR3 as a surrogate marker of basophil activation and function.We examined the correlative relationship between CCR3 expression on the surface of donor basophils and ...
Aaruni, Khanolkar, Steven J, Burden, Benjamin, Hansen, Andrew R, Wilson, Gregory J, Philipps, Harry R, Hill   +5 more
openaire   +2 more sources

Lack of CCR3 leads to a skeletal phenotype only in male mice

, 2022
We recently showed that adult male mice that lacked the C–C-chemokine receptor 3 (CCR3) exhibited disturbed bone remodeling, which resulted in a cortical bone phenotype of thin femoral cortical bone.
Lundberg, Pernilla, Kindstedt, Elin,, Forsberg, Sebastian, Sulniute, Rima, Forsberg, Sebastian,, Drewsen, Viktor,, Drewsen, Viktor, Häggvik, Rebecka, Koskinen Holm, Cecilia,, Lundberg, Pernilla,, Häggvik, Rebecka,, Rosendahl, Sara, Persson, Julia, Kindstedt, Elin, Sulniute, Rima,, Persson, Julia,, Rosendahl, Sara,, Koskinen Holm, Cecilia   +17 more
core   +1 more source

Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets [PDF]

, 2017
The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation, migration, and/or the release of wound healing mediators.
Buskermolen, Jeroen K., Roffel, Sanne, Gibbs, Susan   +2 more
core   +2 more sources

The expression of CCL11/eotaxin, CCR3 receptor and eosinophil peroxidase in tumor tissue in gastric and colon cancers

Бюллетень сибирской медицины, 2018
The purpose of the study was to analyze the expression of CCL11/eotaxin, CCR3 receptor to eotaxin and eosinophil peroxidase (EXP) in tumor tissue and its relation to tissue eosinophilia in gastric and colon cancers.Materials and methods. 52 patients with
Yu. V. Kolobovnikova, K. I. Yankovich, E. V. Romanova, A. I. Dmitrieva, V. V. Novitskiy, O. I. Urazova   +5 more
doaj   +1 more source

Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness [PDF]

, 2019
Background—Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma. To date, none of the CCR3 antagonists have shown efficacy in clinical trials.
Lee K. Rousslang, Nadya I. Tarasova, Ben Hitchinson, Park, Gye Young, Gye Young Park, Abdelkarim, Hazem, Tarasova, Nadya I., Ackerman, Steven J., Anantha Harijith, Vadim Gaponenko, Steven J. Ackerman, Milica Grozdanovic, Laffey, Kimberly G, Furuta, Glenn T., Masterson, Joanne C., Gaponenko, Vadim, Hazem Abdelkarim, Kimberly G. Laffey, Moon, Hyung-Geon, Glenn T. Furuta, Joanne C. Masterson, Harijith, Anantha, Rousslang, Lee K., Grozdanovic, Milica, Hitchinson, Ben, Hyung-Geon Moon   +25 more
core   +1 more source

Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling

Frontiers in Molecular Biosciences, 2021
Cholesterol as an allosteric modulator of G protein-coupled receptor (GPCR) function is well documented. This quintessential mammalian lipid facilitates receptor–ligand interactions and multimerization states.
Evan van Aalst, Benjamin J. Wylie
doaj   +1 more source

CCR3 antagonist impairs estradiol-induced eosinophil migration to the uterus in ovariectomized mice [PDF]

Brazilian Journal of Medical and Biological Research, 2019
Eosinophils are abundant in the reproductive tract, contributing to the remodeling and successful implantation of the embryo. However, the mechanisms by which eosinophils migrate into the uterus and their relationship to edema are still not entirely ...
J.M.D. Araújo, L.A.S. Silva, F.B. Felix, E.A. Camargo, R. Grespan   +4 more
doaj   +1 more source

CCL22 induces pro-inflammatory changes in fibroblast-like synoviocytes

iScience, 2021
Summary: Synovitis is common in patients with osteoarthritis (OA) and is associated with pain and disease progression. We have previously demonstrated that the chemokine C-C motif chemokine 22 (CCL22) induces chondrocyte apoptosis in vitro; however, the ...
Guomin Ren, Nedaa Al-Jezani, Pamela Railton, James N. Powell, Roman J. Krawetz   +4 more
doaj   +1 more source