Results 31 to 40 of about 22,866 (205)

Eosinophil chemotaxis assay in nasal polyps by using a novel optical device EZ-TAXIScan: Role of CC-chemokine receptor 3

Allergology International, 2016
Background: The chemokine receptor, CC-chemokine receptor 3 (CCR3), and its major ligands, eotaxin, RANTES, and MCP-4, are involved in eosinophil chemotaxis. It is thought that CCR3 plays an important role in the recruitment and activation of eosinophils
Hidekazu Saito, Kohei Honda, Chikara Asaka, Shigeharu Ueki, Kazuo Ishikawa   +4 more
doaj   +1 more source

Chemokine receptors differentially expressed by race category and molecular subtype in the breast cancer TCGA cohort

Scientific Reports, 2022
Racial disparities in mortality due to metastasis remain significant among breast cancer patients. Chemokine receptors contribute to breast tumors and metastatic outcome.
Elissa D. Vazquez, Xiangyi Fang, Lauren A. Levesque, Mike Huynh, Citlali Venegas, Nhien Lu, Nicole Salazar   +6 more
doaj   +1 more source

CCR3-dependent tissue eosinophilia is required for immunity to B. malayi.

, 2018
Enumeration of peritoneal eosinophils (A,B,D,E,G,H) and % recoveries of motile B. malayi in BALB/c WT compared with ΔdblGATA deficient mice (C), in BALB/c WT mice treated with intraperitoneal (ip) rat IgG control or rat anti-CCR3 (αCCR3) (F) or in WT ...
Ana F. Guimaraes (4971982), Julio Furlong-Silva (4971979), Judith E. Allen (107113), Alice Halliday (3536315), Joseph D. Turner (110565), Stephen J. Jenkins (1296537), Nico Van Rooijen (40828), Mark J. Taylor (118298), Nicolas Pionnier (3172716), Darren A. N. Cook (360451), Stephen Cross (4971976), Hanna Sjoberg (4971985), Andrew Steven (268982)   +12 more
core   +1 more source

Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain

Cells, 2022
Neuropathic pain treatment remains a challenging issue because the therapies currently used in the clinic are not sufficiently effective. Moreover, the mechanism of neuropathy is still not entirely understood; however, much evidence indicates that ...
Katarzyna Pawlik, Katarzyna Ciapała, Agata Ciechanowska, Klaudia Kwiatkowski, Joanna Mika   +4 more
doaj   +1 more source

Association between chemokine receptor 3T51C gene polymorphism and different clinical asthma phenotypes in Egyptian asthmatic children

Egyptian Journal of Chest Disease and Tuberculosis, 2023
Background Asthma is a heterogeneous disorder, which is affected by interaction between genes and the surrounding environment. Chemokine receptor 3 (CCR3) which is expressed over eosinophils and Th2 lymphocytes has a significant role in chemoattraction ...
Magdy M. I. Zedan, Mona El wassefy, Islam Nour, Eman O Khashaba, Amal Osman, Eman El Sherbiny   +5 more
doaj   +1 more source

Identification and Characterization of Novel Antagonists of the CCR3 Receptor [PDF]

SLAS Discovery, 2003
Eotaxin, an inducer of eosinophil migration and activation, exerts its activity by binding to CCR3, the C-C chemokine receptor 3. An inhibitor of the eotaxin-CCR3 binding interaction may have potential as an anti-inflammatory drug for treatment of asthma, parasitic infections, and allergic disorders.
Usha, Warrior, Evelyn M, McKeegan, Susan M, Rottinghaus, Lora, Garcia, Linda, Traphagen, George, Grayson, Victoria, Komater, Teresa, McNally, Rosalind, Helfrich, Richard R, Harris, Randy L, Bell, David J, Burns   +11 more
openaire   +2 more sources

Blockade of Autocrine CCL5 Responses Inhibits Zika Virus Persistence and Spread in Human Brain Microvascular Endothelial Cells

mBio, 2021
Zika virus (ZIKV) is a neurovirulent flavivirus that uniquely causes fetal microcephaly, is sexually transmitted, and persists in patients for up to 6 months.
Megan C. Mladinich, Jonas N. Conde, William R. Schutt, Sook-Young Sohn, Erich R. Mackow   +4 more
doaj   +1 more source

Expression of CCR3.

, 2013
Rat eyes were collected 12 days after injection of Matrigel. Cryosections were stained for CCR3 immunoreactivity. A well-developed new blood vessel is clearly present in the Matrigel injected area as revealed by DiI staining (A, arrowhead).
Yiwen Li (354034), Lingyu Luo (354037), Xin Xia (322518), Deqiang Huang (354035), Rong Wen (181335), Zhengying Wang (354036)   +5 more
core   +1 more source

Comparison of CCR3 mRNA and protein levels.

, 2017
(A) mRNA levels of the CCL7 receptors CCR1, CCR2, and CCR3 were measured by RT-PCR. (B) mRNA levels of CCR3 (n = 5) in the nasal mucosa were measured by qPCR.
Dong-Young Kim (463777), Yu-Lian Zhang (3611939), Chae-Seo Rhee (587620), Doo Hee Han (646651), Chul Hee Lee (587621)   +4 more
core   +1 more source

CCR3: Shedding New Light on a Dark Problem? [PDF]

Journal of Molecular Cell Biology, 2009
A recent work by Ambati et al. represents a bold step towards a more effective diagnosis and treatment of age-related macular degeneration, with the new evidence showing that CCR3, a chemokine receptor, is an early marker of and potential therapeutic target for choroidal neovascularization development.
A Brett, Mason, Josephine, Hoh
openaire   +2 more sources