Results 11 to 20 of about 22,866 (205)
Ginsenoside Rg1 Ameliorates the Learning and Memory Deficits of 5xFAD Mice by Inhibiting CCR3 Activity: Insights from In Vivo and In Vitro Investigations [PDF]
PharmaceuticalsBackground/Objectives: Alzheimer’s disease (AD) is characterized by amyloid-beta accumulation and neuroinflammation, yet the molecular target of Ginsenoside Rg1 remains elusive.
Hui Lu +8 more
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miR-30a-3p participates in the development of asthma by targeting CCR3
Open Medicine, 2020 This study aimed to investigate the role and relevant mechanism of miR-30a-3p action in asthma. The results of this study revealed that the expression levels of miR-30a-3p were significantly decreased in the peripheral blood of asthmatic patients.
Li Xiaobo +3 more
doaj +2 more sources
Role of CCR3 in respiratory syncytial virus infection of airway epithelial cells
iScience, 2021 Summary: Respiratory syncytial virus (RSV) infection is the principal cause of severe lower respiratory tract disease and accounts for a significant risk for developing asthma later in life.
Vincent Wellemans +10 more
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Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1
BMC Immunology, 2005 Background CC Chemokine Receptor 3 (CCR3), the major chemokine receptor expressed on eosinophils, binds promiscuously to several ligands including eotaxins 1, 2, and 3.
Koch Laura E +3 more
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What Is the Role of CCR3 in Choroidal Neovascularization?
, 2011 Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the developed world (Klein et al. 1992 ) . AMD presents in two distinct forms: the geographic atrophy and the exudative or “wet” AMD. The wet AMD is characterized by choroidal neovascularization (CNV) in which new blood vessels from the choroid invade the macula ...
Yiwen, Li +5 more
openaire +3 more sources
Advanced Biomedical Research, 2013 Background: CD4+(TH1, and TH2) cell groups in the point of view of chemokine receptor expression were considered in blood of stomach cancer patients. Materials and Methods: The percentage of blood CD4+ T cells expressing chemokine receptors (before and ...
Alireza Andalib +4 more
doaj +2 more sources
Exacerbation of Facial Motoneuron Loss after Facial Nerve Axotomy in CCR3-Deficient Mice
ASN Neuro, 2009 We have previously demonstrated a neuroprotective mechanism of FMN (facial motoneuron) survival after facial nerve axotomy that is dependent on CD4 + Th2 cell interaction with peripheral antigen-presenting cells, as well as CNS (central nervous system ...
Derek A Wainwright +6 more
doaj +2 more sources
The Role of CCL24 in Systemic Sclerosis
Rambam Maimonides Medical Journal, 2023 Systemic sclerosis (SSc) is a chronic immune-mediated disease characterized by microangiopathy, immune dysregulation, and progressive fibrosis of the skin and internal organs.
Hilit Levy +2 more
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Scientific Reports, 2022 The CCR3 gene plays a critical role in allergic airway inflammation, such as allergic rhinitis (AR), and there is an inflammatory signal link between the nasal cavity and the CCR3 gene in bone marrow.
Jiasheng Yuan +8 more
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Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis
Scientific Reports, 2021 Eotaxin-1 (CCL11) induces the migration of different leukocyte types by interacting with CCR3. In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) are pathogenic effectors and a major CCR3-expressing cell.
Kuninobu Wakabayashi +4 more
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