Results 41 to 50 of about 22,866 (205)

Asthma-related inflammation promotes lung metastasis of breast cancer cells through CCL11–CCR3 pathway

Respiratory Research, 2021
Background Mechanisms that preclude lung metastasis are still barely understood. The possible consequences of allergic airways inflammation on cancer dissemination were studied in a mouse model of breast cancer.
S. Bekaert, N. Rocks, C. Vanwinge, A. Noel, D. Cataldo   +4 more
doaj   +1 more source

THE ROLE OF CHEMOKINES IN FIBROMYALGIA

Rheumatology Quarterly
Aim: Chemokines are cytokines that cause chemotaxis to leukocytes and stem cells in inflammation and homeostasis. Fibromyalgia (FM) is characterized by widespread chronic pain and somatic symptoms. The role of immun mediators in the pathogenesis of FM is
Tuba Tülay Koca, Muhammed Seyithanoğlu, Fırat Sakınmaz   +2 more
doaj   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Immunohistochemical Study of Some Chemokines Receptors in Atopic Epidermis: Before and After Treatment with Topical Tacrolimus–steroid Therapy

The Iraqi Journal of Medical Sciences, 2016
Background: Tacrolimus is an immunosuppressive agent used topically, it has been found to be effective in treating moderate to severe atopic dermatitis without causing the atrophy that might occur with prolonged use of topical corticosteroids.
Nidhal AM Mohammed, Ahmad H. Muhana
doaj   +6 more sources

Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome

Acta Dermato-Venereologica, 2019
Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lym­phomatoid papulosis and anaplastic large cell ...
Yuki Shono, Hiraku Suga, Hiroaki Kamijo, Hikari Fujii, Tomonori Oka, Tomomitsu Miyagaki, Naomi Shishido-Takahashi, Makoto Sugaya, Shinichi Sato   +8 more
doaj   +1 more source

Chemokine Receptors—Structure-Based Virtual Screening Assisted by Machine Learning

Pharmaceutics, 2023
Chemokines modulate the immune response by regulating the migration of immune cells. They are also known to participate in such processes as cell–cell adhesion, allograft rejection, and angiogenesis.
Paulina Dragan, Matthew Merski, Szymon Wiśniewski, Swapnil Ganesh Sanmukh, Dorota Latek   +4 more
doaj   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

CCR3 deficiency shifts adaptive to innate-driven immunity in asthma

Journal of Allergy and Clinical Immunology: Global
Background: Because of repeated contact with airborne allergens, patients suffering from allergic asthma experience acute asthma attacks, characterized by shortness of breath, chest tightness, and coughing.
Susanne Krammer, RPh, Zuqin Yang, PhD, Hannah Mitländer, MD, Janina C. Grund, MD, Carol I. Geppert, MD, Ralf J. Rieker, MD, Sabine Zirlik, MD, Susetta Finotto, PhD   +7 more
doaj   +1 more source

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

Animal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren, Xinpei Wang, Wen Wang, Xingjiu Yang, Mengyuan Li, Jing Du, Ran Gao   +6 more
wiley   +1 more source