Results 51 to 60 of about 22,866 (205)

CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease

, 2001
Lymph nodes with Hodgkin disease (HD) harbor few neoplastic cells in a marked leukocytic infiltrate. Since chemokines are likely to be involved in the recruitment of these leukocytes, the expression of potentially relevant chemokines and chemokine ...
Schärli, P, Mueller, C, Patrik Schärli, Daniel Cefai, Laissue, J A, Uguccioni, M, Körner, M, Mariagrazia Uguccioni, Mazzucchelli, L, Christoph Mueller, Caroline Buri, Meike Körner, Jean A. Laissue, Buri, C, Cefai, D, Luca Mazzucchelli   +15 more
core   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Role of Interleukin-17A on the Chemotactic Responses to CCL7 in a Murine Allergic Rhinitis Model. [PDF]

PLoS ONE, 2017
The proinflammatory cytokine interleukin (IL)-17A is associated with eosinophil infiltration into the nasal mucosa in a mouse model of ovalbumin-induced allergic rhinitis.
Yu-Lian Zhang, Doo Hee Han, Dong-Young Kim, Chul Hee Lee, Chae-Seo Rhee   +4 more
doaj   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Comparative analysis of TRPM8 gene and COPD markers expression in rat lungs following exposure to cigarette smoke and tobacco aerosol

Acta Biomedica Scientifica
Background. Chronic Obstructive Pulmonary Disease (COPD) remains a global medical and social problem. The ion channel TRPM8, a cold receptor, is known to be involved in the pathogenesis of the disease.
P. D. Timkin, M. A. Kiselev, D. A. Shapovalova, D. E. Naumov, P. M. Linskaya, E. A. Borodin   +5 more
doaj   +1 more source

Simvastatin Inhibits IL-5-Induced Chemotaxis and CCR3 Expression of HL-60-Derived and Human Primary Eosinophils. [PDF]

PLoS ONE, 2016
IL-5-induced chemotaxis of eosinophils is an important feature of allergic airway inflammatory diseases. Simvastatin, a lipid lowering agent, has been shown to exhibit anti-inflammatory and anti-allergic effects.
Chia-Hsiang Fu, Wan-Chun Tsai, Ta-Jen Lee, Chi-Che Huang, Po-Hung Chang, Jong-Hwei Su Pang   +5 more
doaj   +1 more source

Successful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin

Allergy, EarlyView.
This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...
Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga   +11 more
wiley   +1 more source

Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils

, 1997
Background: The chemokine eotaxin is produced at sites of allergic inflammation, binds selectively to the chemokine receptor CCR3 and attracts eosinophil and basophil leukocytes, which express high numbers of this receptor.
Gerber, B.O., Yawalkar, N., B.O. Gerber, M. Baggiolini, Moser, B., Uguccioni, M., M. Loetscher, Baggiolini, M., N. Yawalkar, C.R. Mackay, W.J. Pichler, M. Uguccioni, B. Moser, Loetscher, M., Zanni, M.P., Pichler, W.J., Mackay, C.R., M.P. Zanni   +17 more
core   +1 more source

In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3

Membranes, 2021
CC motif chemokine receptor 3 (CCR3) is a Class A G protein-coupled receptor (GPCR) mainly responsible for the cellular trafficking of eosinophils. As such, it plays key roles in inflammatory conditions, such as asthma and arthritis, and the metastasis ...
Evan van Aalst, Jotham Koneri, Benjamin J. Wylie   +2 more
doaj   +1 more source