Results 31 to 40 of about 7,919 (172)
Molecular Pain, 2023 Background Chemokine-mediated neuroinflammation plays an important role in the pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor CCR2 have been reported to contribute to neuropathic pain via astrocyte-microglial ...
Lin-Peng Zhu +4 more
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Biomedicines, 2023 Recruitment to the local tissue and alerted phenotype are the hallmarks of basophils in chronic urticaria (CU). Chemokine receptors such as chemokine (C-C motif) receptor 4 (CCR4) or CCR8 have been studied in skin diseases, e.g., atopic dermatitis, but ...
Ewa A. Bartko +4 more
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Expression of CCR3 and CCR4 Suggests a Poor Prognosis in Mycosis Fungoides and Sézary Syndrome
Acta Dermato-Venereologica, 2019 Tumor cells in cutaneous T-cell lymphoma express limited numbers of chemokine receptors. We investigated the expression patterns of CXCR3, CCR3, CCR4 and CCR10 in mycosis fungoides, Sézary syndrome, lymphomatoid papulosis and anaplastic large cell ...
Yuki Shono +8 more
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High-level production, solubilization and purification of synthetic human GPCR chemokine receptors CCR5, CCR3, CXCR4 and CX3CR1. [PDF]
PLoS ONE, 2009 Chemokine receptors belong to a class of integral membrane G-protein coupled receptors (GPCRs) and are responsible for transmitting signals from the extracellular environment.
Hui Ren +5 more
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Exacerbation of Facial Motoneuron Loss after Facial Nerve Axotomy in CCR3-Deficient Mice
ASN Neuro, 2009 We have previously demonstrated a neuroprotective mechanism of FMN (facial motoneuron) survival after facial nerve axotomy that is dependent on CD4 + Th2 cell interaction with peripheral antigen-presenting cells, as well as CNS (central nervous system ...
Derek A Wainwright +6 more
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Advanced Biomedical Research, 2013 Background: CD4+(TH1, and TH2) cell groups in the point of view of chemokine receptor expression were considered in blood of stomach cancer patients. Materials and Methods: The percentage of blood CD4+ T cells expressing chemokine receptors (before and ...
Alireza Andalib +4 more
doaj +1 more source
Cells, 2022 Neuropathic pain treatment remains a challenging issue because the therapies currently used in the clinic are not sufficiently effective. Moreover, the mechanism of neuropathy is still not entirely understood; however, much evidence indicates that ...
Katarzyna Pawlik +4 more
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The CC chemokine receptor 3 CCR3 is functionally expressed on eosinophils but not on neutrophils [PDF]
European Journal of Immunology, 2000 The chemokine subclasses differ in their biological activity to stimulate different kinds of effector cells via distinct chemokine receptors. Controversial results about the expression of the CC chemokine receptor CCR3 on the surface of human neutrophils have been described.
R, Höchstetter +5 more
openaire +2 more sources
Small Molecule Receptor Agonists and Antagonists of CCR3 Provide Insight into Mechanisms of Chemokine Receptor Activation [PDF]
Journal of Biological Chemistry, 2007 Chemokine receptor CCR3 is highly expressed by eosinophils and signals in response to binding of the eotaxin family of chemokines, which are up-regulated in allergic disorders. Consequently, CCR3 blockade is of interest as a possible therapeutic approach for the treatment of allergic disease. We have described previously a bispecific antagonist of CCR1
Emma L, Wise +5 more
openaire +2 more sources
Frontiers in Immunology, 2018 Leptin is a cytokine, produced mainly by mature adipocytes, that regulates the central nervous system, mainly to suppress appetite and stimulate energy expenditure.
Natália R. T. Amorim +10 more
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