Results 71 to 80 of about 13,208 (193)

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Plasma levels of CCL11, CCL4 and CCL3 in female FM patients with varCCL11 or varCCL4.

, 2018
A-C, CCL11, CCL4, and CCL3 levels in female healthy controls (Ctrl, n = 48) vs female FM patients with wild type CCL11 (n = 19) or var CCL11 (n = 14). D-F, CCL4, CCL3 and CCL11 levels in female healthy controls (Ctrl, n = 48) vs wild type CCL4 (n = 49 ...
Susan L. Neuhausen (238692), John E. Shively (173276), Jeffrey Longmate (255317), Allen Mao (419755), Xiwei Wu (136542), Deirdre La Placa (5435573), Keith Le (419759), Claudia Marek (255319), Jinong Feng (255302), Zhifang Zhang (47768), R. Paul St. Amand (255320)   +10 more
core   +1 more source

Differential Roles for IL‐4Rα and IL‐13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis

Allergy, EarlyView.
This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva, Shraddha Sharma, Shireen Barakey, Ariel Wagner, Alice Keisar, Tali Bar‐on, Michal Itan, Ariel Munitz   +7 more
wiley   +1 more source

Assessing the role of eosinophil‐mediated immune response markers in detecting hookworm infection: A case‐control study in Kintampo, Ghana

Health Science Reports, 2022
Background and Aim Human hookworm disease caused by Ancylostoma duodenale and Necator americanus is a serious public health problem. Hookworm infection activates eosinophil‐mediated tissue inflammatory responses, involving the production of the ...
Samuel A. Sakyi, Benjamin Amoani, Stephen Opoku, Lawrence Dzata, Wilfred Aniagyei, Ebenezer Senu, Kwabena Dankwa, Michael D. Wilson   +7 more
doaj   +1 more source

CCL11–CCR3 Interactions Promote Survival of Anaplastic Large Cell Lymphoma Cells via ERK1/2 Activation

, 2011
CCR3 is a specific marker of anaplastic large cell lymphoma (ALCL) cells. ALCL cells also express CCL11, a ligand for CCR3, leading to the hypothesis that CCL11 may play an autocrine role in ALCL progression.
Yayoi Tada, Hitoshi Okochi, Shinichi Sato, Makoto Sugaya, Takafumi Kadono, Takashi Murakami, Kunihiko Tamaki, Tomomitsu Miyagaki, Yoshihide Asano   +8 more
core   +1 more source

Distinct Immunometabolic Profiles in Finnish and Russian Karelian Adolescents With Contrasting Allergy Risk

Allergy, EarlyView.
We compared Finnish and Russian Karelian adolescents with contrasting allergy burden using integrated proteomic, metabolomic, and transcriptomic profiling. Finnish adolescents showed a broader pro‐inflammatory PBMC secretory profile consistent with a low‐grade inflammatory phenotype.
Nanna Fyhrquist, Matilda Riskumäki, Piia Karisola, Anni Nieminen, Tiina Laatikainen, Hanna Sinkko, Laura Paalanen, Pekka Jousilahti, Erkki Vartiainen, Mika J. Mäkelä, Tari Haahtela, Harri Alenius   +11 more
wiley   +1 more source

Pathogenic Airway Bacteria and Local Immune Responses During Early‐Life Asthma‐Like Episodes

Allergy, EarlyView.
This study investigates how Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis associate with airway immune responses during early‐life asthma‐like episodes, and compare these responses between children with and without asthma.
Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann‐Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard   +12 more
wiley   +1 more source

High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+ T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control

Frontiers in Immunology, 2018
Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIV-ECs) with a suppressed viremia.
Mónica Gutiérrez-Rivas, María Ángeles Jiménez-Sousa, Norma Rallón, Norma Rallón, José Luis Jiménez, José Luis Jiménez, Clara Restrepo, Clara Restrepo, Agathe León, Marta Montero-Alonso, Juan González-García, María Ángeles Muñoz-Fernández, María Ángeles Muñoz-Fernández, José Miguel Benito, José Miguel Benito, Salvador Resino, on Behalf of ECRIS Integrated in the Spanish AIDS Research Network   +16 more
doaj   +1 more source

Zeb2 Controls Retinal Physiological and Pathological Angiogenesis by Regulating Astrocyte Proliferation and Differentiation

Cell Proliferation, EarlyView.
During development, the oxygen‐sensitive transcription factor Zeb2 restrains astrocyte proliferation and maturation to ensure balanced retinal angiogenesis. In disease, it promotes the neurotoxic A1 astrocyte phenotype and inflammation, thereby promoting reparative revascularization over pathological neovascularization.
Jing Liu, Yanan Guo, Kangjian Xiang, Shuyi Wang, Dongchang Xiao, Mengqing Xiang   +5 more
wiley   +1 more source

Colonic Eosinophilic Inflammation in Experimental Colitis Is Mediated by Ly6Chigh CCR2+ Inflammatory Monocyte/Macrophage-Derived CCL11

, 2011
Recent genome-wide association studies of pediatric inflammatory bowel disease have implicated the 17q12 loci, which contains the eosinophil-specific chemokine gene CCL11, with early-onset inflammatory bowel disease susceptibility.
Simon P. Hogan, Kris Steinbrecher, Amanda Waddell, Burke Donovan, Ariel Munitz, Richard Ahrens, Marc E. Rothenberg   +6 more
core   +1 more source