The chemokine CCL3 promotes experimental liver fibrosis in mice. [PDF]
PLoS ONE, 2013 Liver fibrosis is associated with infiltrating immune cells and activation of hepatic stellate cells. We here aimed to investigate the effects of the CC chemokine CCL3, also known as macrophage inflammatory protein-1α, in two different fibrosis models ...
Daniel Heinrichs +7 more
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Chemokines CCL3/MIP1α, CCL5/RANTES and CCL18/PARC are independent risk predictors of short-term mortality in patients with acute coronary syndromes. [PDF]
PLoS ONE, 2012 Cytokines play an important role in ischemic injury and repair. However, little is known about their prognostic value in cardiovascular disease. The aim of this study was to investigate the prognostic importance of chemokines CCL3/MIP-1α, CCL5/RANTES and
Saskia C A de Jager +10 more
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CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes [PDF]
Frontiers in Immunology, 2018 Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity ...
Zachary L. Benet +8 more
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Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3
Cell Communication and SignalingBackground Helicobacter pylori (H. pylori) is the predominant etiological agent of gastritis and disrupts the integrity of the gastric mucosal barrier through various pathogenic mechanisms. After H.
Yan-Fei Wei +7 more
doaj +2 more sources
Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy. [PDF]
Adv Sci (Weinh)POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Wu T +12 more
europepmc +2 more sources
CCL3 as a novel biomarker in the diagnosis of necrotizing enterocolitis
BMC PediatricsObjectives Neonatal necrotizing enterocolitis (NEC) is a common intestinal disease that threatens the lives of newborns and is characterized by ischemic necrosis of the small intestine and colon.
Li Zeng +7 more
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Chemokine Ligand-3 (CCL3) as a Novel Mediator of Inflammatory Bowel Disease Activity. [PDF]
Gastro Hep AdvInflammatory bowel disease (IBD) is characterized by dysregulation of the immune system, driven in part by pro-inflammatory macrophage polarization. Chemokine ligand-3 (CCL3) is a chemokine known to mediate Th1 responses in inflammatory conditions and ...
O'Brien E +5 more
europepmc +2 more sources
Unveiling the Role of CCL3: A Driver of CIPN in Colon Cancer Patients?
BiomedicinesCancer neuroscience is an emerging field revealing how malignancies interact with the nervous system to shape disease progression and symptom burden.
Irene Luzac +2 more
doaj +2 more sources
Journal for ImmunoTherapy of Cancer, 2022 Background Although the antitumor efficacy of docetaxel (DTX) has long been attributed to the antimitotic activities, its impact on the tumor microenvironment (TME) has recently gained more attention. Macrophages are a major component of the TME and play
Tong Liu +17 more
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Effect of Mesenchymal Stem Cells’ Conditioned Medium on the Expression of CCL3 and CCL4 Chemokines in the Spinal Cord of Rats with Neuropathic Pain [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: Inflammation plays an important role in the development of neuropathic pain (NP). Considering the anti-inflammatory effects of mesenchymal stem cells (MSCs) and their conditioned medium (CM), we aimed to investigate the effect of ...
Mohammad-Shafi Mojadadi +3 more
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