Results 21 to 30 of about 39,533 (201)

Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepatic steatosis, and adipose tissue expansion. [PDF]

PLoS ONE, 2012
Macrophage inflammatory protein-1α (CCL3) plays a well-known role in infectious and viral diseases; however, its contribution to atherosclerotic lesion formation and lipid metabolism has not been determined.
Arion Kennedy, Marnie L Gruen, Dario A Gutierrez, Bonnie K Surmi, Jeb S Orr, Corey D Webb, Alyssa H Hasty   +6 more
doaj   +1 more source

Zoledronic acid impairs oral cancer stem cells by reducing CCL3. [PDF]

, 2021
Cancer stem‑like cells (CSCs; also referred to as tumor‑initiating cells) play crucial roles in tumor progression and aggressiveness. Recent studies have demonstrated the antitumor activity of zoledronic acid (ZA), a third‑generation bisphosphonate, in ...
Rigas, Nicole, Nguyen, Anthony, Martin, Charlotte, Lee, Sung, Park, No-Hee, Kang, Mo, Kim, Reuben, Shin, Ki-Hyuk   +7 more
core   +1 more source

CCL3/Macrophage Inflammatory Protein-1α Is Dually Involved in Parasite Persistence and Induction of a TNF- and IFNγ-Enriched Inflammatory Milieu in Trypanosoma cruzi-Induced Chronic Cardiomyopathy

Frontiers in Immunology, 2020
CCL3, a member of the CC-chemokine family, has been associated with macrophage recruitment to heart tissue and parasite control in the acute infection of mouse with Trypanosoma cruzi, the causative agent of Chagas disease.
Daniel Gibaldi, Glaucia Vilar-Pereira, Isabela Resende Pereira, Andrea Alice Silva, Leda Castaño Barrios, Isalira Peroba Ramos, Isalira Peroba Ramos, Hílton Antônio Mata dos Santos, Ricardo Gazzinelli, Joseli Lannes-Vieira   +9 more
doaj   +1 more source

miR-4456/CCL3/CCR5 Pathway in the Pathogenesis of Tight Junction Impairment in Chronic Obstructive Pulmonary Disease

Frontiers in Pharmacology, 2021
Background: Cigarette smoke exposure (CSE) is a major cause of chronic obstructive pulmonary disease (COPD). The smoke disrupts cell-cell adhesion by inducing epithelial barrier damage to the tight junction (TJ) proteins.
Weiwei Yu, Ting Ye, Jie Ding, Yi Huang, Yang Peng, Qin Xia, Zhang Cuntai   +6 more
doaj   +1 more source

Novel Therapeutic Targeting of CCL3-CCR4 Axis Mediated Apoptotic Intesitnal Injury in Necrotizing Enterocolitis

Frontiers in Immunology, 2022
BackgroundNecrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal-related death, while the etiology and pathogenesis are poorly understood.MethodsThe levels of CCL3 in intestinal tissue from modeling mice and patients were ...
Xi Yuan, Zihan Xiong, Wei Liu, Yue Li, Hongdong Li, Xuemei Zhang, Yibing Yin, Pingyong Xu, Pingyong Xu, Pingyong Xu, Ju Cao, Dapeng Chen, Zhixin Song   +12 more
doaj   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga, Nina Berberich, Peter Bihari, Stefan Zahler, Rehberg, Markus, Fritz Krombach, Krombach, Fritz, Max Lerchenberger, Lerchenberger, Max, Berberich, Nina, Reichel, Christoph A., Christoph Andreas Reichel, Markus Rehberg, Bihari, Peter, Zahler, Stefan, Khandoga, Alexander G.   +15 more
core   +1 more source

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway

Biomedicines, 2020
Increased circulatory and adipose tissue expression of macrophage inflammatory protein (MIP)-1α (CC motif chemokine ligand-3/CCL3) and its association with inflammation in the state of obesity is well documented.
Shihab Kochumon, Hossein Arefanian, Rafaat Azim, Steve Shenouda, Texy Jacob, Nermeen Abu Khalaf, Fatema Al-Rashed, Amal Hasan, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad   +10 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ

OncoImmunology, 2018
Inflammatory chemokines are critical contributors in attracting relevant immune cells to the tumor microenvironment and driving cellular interactions and molecular signaling cascades that dictate the ultimate outcome of host anti-tumor immune response ...
Frederick Allen, Iuliana D. Bobanga, Peter Rauhe, Deborah Barkauskas, Nathan Teich, Caryn Tong, Jay Myers, Alex Y. Huang   +7 more
doaj   +1 more source