Interferon-gamma coordinates CCL3-mediated neutrophil recruitment
BMC Immunology, 2009 Background We have shown previously that acute infection with the respiratory pathogen, pneumonia virus of mice (PVM), results in local production of the proinflammatory chemokine, CCL3, and that neutrophil recruitment in response to PVM infection is ...
Foster Barbara +7 more
doaj +1 more source
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice. [PDF]
PLoS Pathogens, 2010 Neutrophils are rapidly and massively recruited to sites of microbial infection, where they can influence the recruitment of dendritic cells. Here, we have analyzed the role of neutrophil released chemokines in the early recruitment of dendritic cells ...
Mélanie Charmoy +7 more
doaj +1 more source
CCL3 contributes to secondary damage after spinal cord injury
Journal of Neuroinflammation, 2020 Background Secondary damage after spinal cord injury (SCI) is characterized by a cascade of events including hemorrhage, apoptosis, oxidative stress, and inflammation which increase the lesion size which can influence the functional impairment.
Nicolas Pelisch +4 more
doaj +1 more source
CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice
JCI Insight, 2023 The central physiological role of the bone marrow renders bone marrow stromal cells (BMSCs) particularly sensitive to aging. With bone aging, BMSCs acquire a differentiation potential bias in favor of adipogenesis over osteogenesis, and the underlying ...
Degang Yu +9 more
doaj +1 more source
Unraveling the crucial role of CCL3 in nasopharyngeal carcinoma: bioinformatics and immunohistochemical insights [PDF]
Journal of Pathology and Translational MedicineBackground C-C motif chemokine ligand 3 (CCL3) is a crucial chemokine that plays a fundamental role in the immune microenvironment and is closely linked to the development of various cancers.
Xiaopeng Guo +6 more
doaj +1 more source
Evasins: Biology and Therapeutic Potential of Broad-Spectrum Chemokine Inhibitors. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Bialek EL +3 more
europepmc +2 more sources
, 2022 BackgroundNecrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal-related death, while the etiology and pathogenesis are poorly understood.MethodsThe levels of CCL3 in intestinal tissue from modeling mice and patients were ...
Xuemei Zhang (89768) +10 more
core +1 more source
Methodological Considerations on Neutrophil-Macrophage Crosstalk in Gastric Cancer Under Chemo Immunotherapy. [PDF]
Cancer SciCancer Science, EarlyView.
You H, Tang S.
europepmc +2 more sources
Polymorphism in halogen-ethane derivatives: CCl3-CCl3 and ClF2C-CF2Cl
, 2013 The polymorphism of hexachloroethane, Cl3C−CCl3, has been reinvestigated by means of X-ray and neutron scattering. The long time unknown structure of the intermediate phase II of Cl3C−CCl3 has been determined as monoclinic C2/m, with lattice ...
Mondieig, Denise +6 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source