Archives of Clinical Neuropsychology, 2022 Objective: CCM1 is a rare condition that confers risk for negative neurological sequelae, including hemorrhage, seizures, and chronic headache. This study examines cognitive and psychosocial functioning in pediatric patients with CCM1 and describes ...
C. Petranovich +5 more
semanticscholar +1 more source
CCM1 and the second life of proteins in adhesion complexes [PDF]
Cell Adhesion & Migration, 2014 It is well recognized that a number of proteins present within adhesion complexes perform discrete signaling functions outside these adhesion complexes, including transcriptional control. In this respect, β-catenin is a well-known example of an adhesion protein present both in cadherin complexes and in the nucleus where it regulates the TCF ...
Maaike C W, van den Berg +1 more
openaire +2 more sources
A Case Report and Overview of Familial Cerebral Cavernous Malformation Pathogenesis in an Adult Patient [PDF]
, 2018 OBJECTIVE We present a case of a 39 year-old woman who presented with a solitary cavernous malformation hemorrhage without any other lesions, and subsequently presented several months later with a new hemorrhage from a de novo lesion.
Arul, BS, Manu K. +2 more
core +2 more sources
Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. [PDF]
, 2015 PurposeThe phenotypic manifestations of cerebral cavernous malformation disease caused by rare PDCD10 mutations have not been systematically examined, and a mechanistic link to Rho kinase-mediated hyperpermeability, a potential therapeutic target, has ...
Akers, Amy L +16 more
core +2 more sources
Climatological features of blocking anticyclones: a study of Northern Hemisphere CCM1 model blocking events in present-day and double CO2 concentration atmospheres [PDF]
, 1997 http://solberg.snr.missouri.edu/gcc/Using output made with the National Center for Atmospheric Research (NCAR) Community Climate Model Version 1 (CCM1), the characteristics of blocking events over the Northern Hemisphere in a ten-year present day ...
Lupo, Anthony R., 1966- +2 more
core +1 more source
Frontiers in Oncology, 2023 Cerebral cavernous malformation (CCM) is a vascular malformation of the central nervous system and mainly characterized by enlarged capillary cavities without intervening brain parenchyma. Genetic studies have identified three disease-causing genes (CCM1/
Zhenxing Liu +3 more
doaj +1 more source
PDCD10 gene mutations in multiple cerebral cavernous malformations. [PDF]
PLoS ONE, 2014 Cerebral cavernous malformations (CCMs) are vascular abnormalities that may cause seizures, intracerebral haemorrhages, and focal neurological deficits.
Maria Sole Cigoli +22 more
doaj +1 more source
Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.
PLoS Biology, 2020 Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery.
Jia Li +12 more
doaj +1 more source
Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice. [PDF]
PLoS ONE, 2016 Mutations in CCM1 (aka KRIT1), CCM2, or CCM3 (aka PDCD10) gene cause cerebral cavernous malformation in humans. Mouse models of CCM disease have been established by deleting Ccm genes in postnatal animals.
Jaesung P Choi +7 more
doaj +1 more source
Modelo de cuantificación del consumo energético en edificación [PDF]
, 2012 The research conducted in this paper focuses on the generation of a model for the quantification of energy consumption in building. This is to be done through one of the most relevant environmental impact indicators associated with weight per m2 of ...
Mercader-Moyano, Pilar +2 more
core +2 more sources