Results 41 to 50 of about 2,140 (195)
The effect of different hydration media on magnesia
Discover Materials, 2021 This paper discusses the rate of hydration of magnesia (CCM1 and CCM2) during the formation of magnesium hydroxide with magnesium acetate and distilled water.
Friedrich von Hoessle +5 more
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Role of pericytes in the development of cerebral cavernous malformations
iScience, 2022 Summary: Cerebral cavernous malformation (CCM) is caused by loss-of-function mutations in CCM1, CCM2, or CCM3 genes of endothelial cells. It is characterized by pericyte deficiency. However, the role of pericytes in CCMs is not yet clarified.
Zifeng Dai +15 more
doaj +1 more source
Spanish families with cavernous angiomas do not share the Hispano- American CCM1 haplotype [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1999 Cerebral cavernous malformations are vascular malformations mostly located in the CNS. Their frequency is estimated close to 0.5% in the general population.1 Cerebral cavernous malformations occur as a sporadic or hereditary condition. From the Hispano-American population, familial forms were reported with a high frequency.2 CCM1 , a hitherto ...
H H, Jung +9 more
openaire +2 more sources
Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3.
, 2020 Loss-of-function variants in CCM1/KRIT1, CCM2, and CCM3/PDCD10 are associated with autosomal dominant cerebral cavernous malformations (CCMs). CRISPR/Cas9-mediated CCM3 inactivation in human endothelial cells (ECs) has been shown to induce profound ...
Strom, T.M. +19 more
core +1 more source
Molecular diagnosis in cerebral cavernous malformations
Neurología (English Edition), 2017 Introduction: Cerebral cavernous malformations (CCMs; OMIM 116860) are enlarged vascular cavities without intervening brain parenchyma whose estimated prevalence in the general population is between 0.1% and 0.5%.
R. Mondejar, M. Lucas
doaj +1 more source
Novel KRIT1/CCM1 mutation in a patient with retinal cavernous hemangioma and cerebral cavernous malformation [PDF]
, 2010 Retinal cavernous hemangiomas are rare vascular anomalies, and can be associated with cerebral cavernous malformations (CCM). Distinct mutations have been reported in patients who have both CCMs and retinal cavernous hemangiomas. Fluorescein angiography,
Michael B. Gorin +9 more
core +1 more source
A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation
Frontiers in Neurology, 2020 Cerebral cavernous malformations (CCMs) are the second most prevalent type of vascular malformation within the central nervous system. CCMs occur in two forms—sporadic and familial—the latter of which has an autosomal dominant mode of inheritance with ...
Lipeng Yang, Jian Wu, Jing Zhang
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Ccm1is required for arterial morphogenesis: implications for the etiology of human cavernous malformations [PDF]
Development, 2004 Hemorrhagic stroke is a significant cause of morbidity and mortality in children, and is frequently associated with intracranial vascular malformations. One prevalent form of these vascular malformations, cerebral cavernous malformation, is characterized by thin-walled vascular cavities that hemorrhage and has been linked to loss-of-function mutations ...
Kevin J, Whitehead +4 more
openaire +2 more sources
Advanced Science, EarlyView.In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng +17 more
wiley +1 more source
Cells, 2021 Cerebral cavernous malformations (CCMs) are vascular lesions that affect predominantly microvasculature in the brain and spinal cord. CCM can occur either in sporadic or familial form, characterized by autosomal dominant inheritance and development of ...
Giulia Riolo +2 more
doaj +1 more source