Results 61 to 70 of about 1,858 (192)

Implementation and Optimization of a Random Illumination Microscope: towards Robustness for Microscopy Core Facility

Biology of the Cell, Volume 118, Issue 3, March 2026.
We present the implementation of our RIM prototype within a microscopy core facility. We describe the system setup, characterization, and optimization, and, as a proof of concept, we provide biological examples demonstrating the prototype's performance, here in resolving microvilli brush border intestine in adult C. elegans.
Nina Soler, Gilles Le Marchand, Stéphanie Dutertre, Xavier Pinson, Munish, Grégoire Michaux, Loïc Schmitt, Hélène Bouvrais, Claire Caron, Nicolas Jolivet, Giulia Bertolin, Simon Labouesse, Thomas Mangeat, Marc Tramier   +13 more
wiley   +1 more source

The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity [PDF]

Journal of Cell Science, 2018
ABSTRACT Endothelial integrity relies on a mechanical crosstalk between intercellular and cell–matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes.
Lisowska, Justyna, Rödel, Claudia, Manet, Sandra, Miroshnikova, Yekaterina, Boyault, Cyril, Planus, Emmanuelle, de Mets, Richard, Lee, Hsiao-Hui, Destaing, Olivier, Mertani, Hichem, Boulday, Gweńola, Tournier-Lasserve, Elisabeth, Balland, Martial, Abdelilah-Seyfried, Salim, Albiges-Rizo, Corinne, Faurobert, Eva   +15 more
openaire   +4 more sources

Fibronectin rescues aberrant phenotype of endothelial cells lacking either CCM1, CCM2 or CCM3.

, 2020
Loss-of-function variants in CCM1/KRIT1, CCM2, and CCM3/PDCD10 are associated with autosomal dominant cerebral cavernous malformations (CCMs). CRISPR/Cas9-mediated CCM3 inactivation in human endothelial cells (ECs) has been shown to induce profound ...
Strom, T.M., Rath, M., Much, C.D., Riedel, K., Kirchmaier, B.C., Dellweg, P.K.E., Pané-Farré, J., Spiegler, S., Felbor, U., Schwefel, K.   +9 more
core   +1 more source

Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

Nature Communications, 2021
Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures.
Huanjiao Jenny Zhou, Lingfeng Qin, Quan Jiang, Katie N. Murray, Haifeng Zhang, Busu Li, Qun Lin, Morven Graham, Xinran Liu, Jaime Grutzendler, Wang Min   +10 more
doaj   +1 more source

Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM)

Antioxidants, 2022
Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti, Rosalia Canzoneri, Andrea Perrelli, Carlo Arduino, Andrea Zonta, Alfredo Brusco, Saverio Francesco Retta   +6 more
doaj   +1 more source

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt, Elizaveta Melnikova, Eugenio Gutiérrez, Vladimir Matchkov, Leif Østergaard, Dmitry D Postnov   +5 more
wiley   +1 more source

A novel CCM1 mutation associated with multiple cerebral and vertebral cavernous malformations [PDF]

, 2014
Background: Cerebral cavernous malformations are relatively rare vascular disorders that may affect any part of the central nervous system. This presentation has been associated with heterozygous mutations in CCM1/KRIT1, CCM2/malcavernin and CCM3/PDCD10.
D. Ronchi, N. Bresolin, G.P. Comi, Naghia Ahmed, S. Corti, Silvia Lanfranconi, Nereo Bresolin, Stefania Corti, Paola Basilico, Giacomo Pietro Comi, V. Civelli, P. Basilico, Vittorio Civelli, Dario Ronchi, S. Lanfranconi, N. Ahmed   +15 more
core   +1 more source

Cerebral cavernous malformations: Review of the genetic and protein-protein interactions resulting in disease pathogenesis

Frontiers in Surgery, 2016
Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions comprised of aberrantly enlarged cavernous endothelial channels that can result in cerebral ...
Jacob F. Baranoski, M. Yashar S. Kalani, Joseph M. Zabramski   +2 more
doaj   +1 more source

Molecular Diagnosis in a Specialised Neurogenetic Clinic With Access to Whole‐Genome Sequencing

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Background Rare diseases, collectively affecting 1 in 17 people in the United Kingdom and Ireland, require coordinated care. Specialised multidisciplinary clinics offer a streamlined approach for diagnosis and management of rare neurogenetic disorders.
Patrick B. Moloney, Nicholas W. Wood, Rob Rouhl   +2 more
wiley   +1 more source

Label free super resolution imaging with photonic nanojets from tunable tapered optical fibers

Nanophotonics, Volume 14, Issue 22, Page 3669-3680, 01 November 2025.
Abstract We demonstrate a label‐free, far‐field super‐resolution imaging approach based on photonic nanojets generated by tapered dielectric fibers. By systematically analyzing the dependence of nanojet confinement and focal distance on cylinder diameter (8–16 μm), we establish a geometric design framework for tunable light localization below the ...
Maya Hen Shor Peled, Göran Maconi, Ivan Kassamakov, Alina Karabchevsky   +3 more
wiley   +1 more source