Results 61 to 70 of about 2,140 (195)

Impact of Modifiable Cardiovascular Risk Factors and Protective Therapies on Hemorrhagic Events in Cerebral Cavernous Malformations: A Systematic Review and Meta‐Analysis

open access: yesBrain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Cerebral cavernous malformations (CCM) are vascular lesions prone to hemorrhage, but the influence of modifiable cardiovascular risk factors and commonly prescribed therapies on bleeding risk remains unclear. Methods We performed a systematic review and meta‐analysis according to PRISMA 2020.
Sai Sanikommu   +10 more
wiley   +1 more source

Cerebral Cavernous Malformation 1 Determines YAP/TAZ Signaling-Dependent Metastatic Hallmarks of Prostate Cancer Cells

open access: yes, 2021
Enhanced Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ) signaling is correlated with the extraprostatic extension of prostate cancer. However, the mechanism by which YAP/TAZ signaling becomes hyperactive and drives
Jaehong Kim   +6 more
core   +1 more source

Coexistence of Ebstein Anomaly and Cerebral Cavernous Malformation: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT In most patients who have Ebstein anomaly (EA), neurological symptoms are either associated with thromboembolic episodes or due to arrhythmic complications. Cerebral cavernous malformation (CCM) is a vascular anomaly made up of sinusoidally dilated blood vessels, often presenting with seizure activity or intracranial bleeding.
Nazmin Ahmed   +5 more
wiley   +1 more source

Pediatric Familial Cerebral Cavernous Malformation Associated With a Novel KRIT1 Initiation‐Region Frameshift Variant

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
A novel KRIT1 initiation‐region frameshift variant, NM_004912.4.2dup [p.(Met1IlefsTer31)], was identified in a pediatric family with familial cerebral cavernous malformation. Marked intrafamilial variability supports early molecular diagnosis, cascade family screening, and susceptibility‐sensitive MRI surveillance. ABSTRACT Background Familial cerebral
Özlem Yayıcı Köken   +5 more
wiley   +1 more source

Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model

open access: yesNature Communications, 2021
Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures.
Huanjiao Jenny Zhou   +10 more
doaj   +1 more source

Direct Measurement of the Singlet Lifetime and Photoexcitation Behavior of the Boron Vacancy Center in Hexagonal Boron Nitride

open access: yesAdvanced Optical Materials, Volume 14, Issue 25, 3 July 2026.
Negatively charged boron vacancy defects in hexagonal boron nitride promise near‐surface quantum sensing, but their internal spin transition rates are only partly understood. This work directly measures the defect's singlet‐state lifetime, 15(3) ns, using a nanosecond rise‐time dual‐pulse photoluminescence‐recovery method, and shows that high laser ...
Richard A. Escalante   +11 more
wiley   +1 more source

Sequencing of exon 5 (reverse strand, CCM1) of CV126 index patient showing mutation c.618_619delinsG.

open access: yes, 2014
Sequencing of exon 5 (reverse strand, CCM1) of CV126 index patient showing mutation c.618_619delinsG.
Francisca Solano (513838)   +9 more
core   +1 more source

Qualitative detection of CCM1, CCM2 and CCM3 and analysis of morphological and proliferative changes after downregulation of expression of CCM1 in HUV endothelialcells

open access: yes, 2011
Kavernome sind vaskuläre Neubildungen im zentralen Nervensystem, welche aus dilatierten, dünnwandigen, sinusoidalen Blutgefäßen bestehen. Histologisch zeigen sich nur anormal vorhandene oder gänzlich fehlende Tight Junctions der Endothelzellen und ...
Hansen, Bodil (138690723)
core   +2 more sources

Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM)

open access: yesAntioxidants, 2022
Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti   +6 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

open access: yesThe FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard   +4 more
wiley   +1 more source

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