Results 81 to 90 of about 2,140 (195)
Biology of the Cell, Volume 118, Issue 3, March 2026.We present the implementation of our RIM prototype within a microscopy core facility. We describe the system setup, characterization, and optimization, and, as a proof of concept, we provide biological examples demonstrating the prototype's performance, here in resolving microvilli brush border intestine in adult C. elegans.
Nina Soler +13 more
wiley +1 more source
Abstract 1645: CEACAM1-blockade for T-cell activation and antitumor T-cell response
, 2017 Immune checkpoint blockade became the most powerful way to control cancer without causing tremendous side effects, since anti-PD-1 blocking antibodies proved their superiority in clinical outcomes to those of traditional chemo- or targeted therapeutics ...
So-Young Eun
core +1 more source
Modellierung der CCM-Pathogenese mit Patienten-spezifischen Endothelzellen [PDF]
, 2021 Zerebrale kavernöse Malformationen (CCM) sind Fehlbildungen im neurovaskulären System, welche aufgrund von Krampfanfällen und hämorrhagischen Schlaganfällen zu einer stark eingeschränkten Lebensqualität führen können.
Much, Christiane Dörte
core +1 more source
PLoS ONE, 2015 Cerebral cavernous malformations are fragile blood vessel conglomerates in the central nervous system that are caused by mutations in the CCM1/KRIT1, CCM2 or CCM3 genes.
Stefanie E Herberich +5 more
doaj +1 more source
Brain and Behavior, Volume 16, Issue 2, February 2026.Mechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Xuesai Zhu +3 more
wiley +1 more source
Two independent activities define Ccm1p as a moonlighting protein in Saccharomyces cerevisiae
Bioscience Reports, 2012 Ccm1p is a nuclear-encoded PPR (pentatricopeptide repeat) protein that localizes into mitochondria of Saccharomyces cerevisiae. It was first defined as an essential factor to remove the bI4 [COB (cytochrome b) fourth intron)] and aI4 [COX1 (cytochrome c ...
J. Ignacio Moreno +5 more
doaj +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt +5 more
wiley +1 more source
, 2013 International audienceThe endothelial CCM complex regulates blood vessel stability and permeability. Loss-of-function mutations in CCM genes are responsible for human cerebral cavernous malformations (CCMs), which are characterized by clusters of ...
Justyna Lisowska +27 more
core +1 more source
Molecular Diagnosis in a Specialised Neurogenetic Clinic With Access to Whole‐Genome Sequencing
Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.Background Rare diseases, collectively affecting 1 in 17 people in the United Kingdom and Ireland, require coordinated care. Specialised multidisciplinary clinics offer a streamlined approach for diagnosis and management of rare neurogenetic disorders.
Patrick B. Moloney +2 more
wiley +1 more source
Regulation and Function of Cerebral Cavernous Malformation Proteins [PDF]
, 2012 Cerebral Cavernous Malformations (CCM) is a genetic disease that causes dilated, leaky blood vessels in the brain and manifests with neurological deficits, seizures and hemorrhagic stroke.
Borikova, Asya Lazarova
core +1 more source