Results 51 to 60 of about 2,140 (195)

Transitivity properties of surface temperature and ice cover in the CCM1

Dynamics of Atmospheres and Oceans, 1998
Abstract A frequently made assumption in simple models of long-term climatic behavior (e.g. ‘energy balance’ models) is that, owing to instability engendered by the ice-albedo feedback, the climatic system (surface temperature, in particular) can exhibit multiple steady states within the paleoclimatologically observed range of temperature.
Barry Saltzman, Haijun Hu, Robert J. Oglesby   +2 more
openaire   +1 more source

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

Heliyon, 2019
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel, Mariana Vasquez, Brian Grajeda, Cameron Ellis, Jun Zhang   +4 more
doaj   +1 more source

Symmetric Off‐Axis Spectral Encoding Enables High‐Throughput Six‐Color Optical Sectioning Imaging

Nanophotonics, Volume 15, Issue 21, 12 November 2026.
Within an off‐axis imaging framework, symmetric spatial encoding enables differential separation of fluorescence components excited at different wavelengths while suppressing common‐mode out‐of‐focus background. Combined with parallel emission‐band detection and residual crosstalk correction, symmetric off‐axis spectral encoding microscopy (sym‐OSEM ...
Jiangjiang Zhao, Zhangheng Ding, Zhan Zhang, Jie Zhang, Shuhong Qi, Jing Yuan   +5 more
wiley   +1 more source

Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype [PDF]

, 2010
Cerebral cavernous malformations (CCM) are vascular lesions causing seizures and stroke. Mutations causing inactivation of one of three genes, ccm1, -2, or -3, are sufficient to induce vascular endothelial cell defects resulting in CCM.
Borikova, Asya L., Dibble, Christopher F., Sciaky, Noah, Welch, Christopher M.   +3 more
core   +2 more sources

Surface Glare Suppression in Retinal Imaging With a Cross‐Polarized Line‐Scanning Color Fundus Camera

Journal of Biophotonics, Volume 19, Issue 11, November 2026.
A line‐scanning color fundus camera combines line‐confocal gating and cross‐polarization to suppress corneal and optical surface glare. Broadband white‐light illumination enables true‐color retinal imaging without pupil dilation across an approximately 60° horizontal field of view, using a compact, relatively low‐cost design. ABSTRACT Fundus imaging is
Xingyu Yang, Zijian Zhang, Xiuju Chen, Philip I. Burgess, Sarah McGhee, Mark Johnson, Ticiana Criddle, Gabriela Czanner, Simon P. Harding, David Wong, Xiaoxin Li, Yalin Zheng, Yaochun Shen   +12 more
wiley   +1 more source

Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors

Frontiers in Bioscience-Landmark
Background: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: KRIT1 (CCM1), MGC4607 (CCM2 ...
Jacob Croft, Liyuan Gao, Victor Sheng, Jun Zhang   +3 more
doaj   +1 more source

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Nature Communications, 2019
Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the
Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras, W. Brent Derry   +14 more
doaj   +1 more source

Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease

Biomedicines, 2023
Cerebral cavernous malformation (CCM) or cavernoma is a major vascular disease of genetic origin, whose main phenotypes occur in the central nervous system, and is currently devoid of pharmacological therapeutic strategies.
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta   +7 more
doaj   +1 more source

The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity [PDF]

Journal of Cell Science, 2018
ABSTRACT Endothelial integrity relies on a mechanical crosstalk between intercellular and cell–matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes.
Lisowska, Justyna, Rödel, Claudia, Manet, Sandra, Miroshnikova, Yekaterina, Boyault, Cyril, Planus, Emmanuelle, de Mets, Richard, Lee, Hsiao-Hui, Destaing, Olivier, Mertani, Hichem, Boulday, Gweńola, Tournier-Lasserve, Elisabeth, Balland, Martial, Abdelilah-Seyfried, Salim, Albiges-Rizo, Corinne, Faurobert, Eva   +15 more
openaire   +4 more sources

Novel Pathogenic Variants in a Cassette Exon of CCM2 in Patients With Cerebral Cavernous Malformations

Frontiers in Neurology, 2019
Autosomal dominant cerebral cavernous malformation (CCM) represents a genetic disorder with a high mutation detection rate given that stringent inclusion criteria are used and copy number variation analyses are part of the diagnostic workflow. Pathogenic
Christiane D. Much, Konrad Schwefel, Dariush Skowronek, Loay Shoubash, Felix von Podewils, Miriam Elbracht, Stefanie Spiegler, Ingo Kurth, Agnes Flöel, Henry W. S. Schroeder, Ute Felbor, Matthias Rath   +11 more
doaj   +1 more source