Results 51 to 60 of about 1,858 (192)

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

Heliyon, 2019
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel, Mariana Vasquez, Brian Grajeda, Cameron Ellis, Jun Zhang   +4 more
doaj   +1 more source

Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease

Biomedicines, 2023
Cerebral cavernous malformation (CCM) or cavernoma is a major vascular disease of genetic origin, whose main phenotypes occur in the central nervous system, and is currently devoid of pharmacological therapeutic strategies.
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta   +7 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

Transitivity properties of surface temperature and ice cover in the CCM1

Dynamics of Atmospheres and Oceans, 1998
Abstract A frequently made assumption in simple models of long-term climatic behavior (e.g. ‘energy balance’ models) is that, owing to instability engendered by the ice-albedo feedback, the climatic system (surface temperature, in particular) can exhibit multiple steady states within the paleoclimatologically observed range of temperature.
Barry Saltzman, Haijun Hu, Robert J. Oglesby   +2 more
openaire   +1 more source

Novel CCM2 missense variants abrogating the CCM1–CCM2 interaction cause cerebral cavernous malformations

, 2020
International audienceCerebral cavernous malformations (CCMs) are vascular malformations mostly located within the central nervous system. Most deleterious variants are loss of function mutations in one of the three CCM genes.
Labauge, Pierre, Riant, Florence, Petit, Paul, Verny, Christophe, Viallet, François, Denier, Christian, Bergametti, Françoise, Chaussenot, Annabelle, Tournier-Lasserve, Elisabeth, Hervé, Dominique, Nouet, Aurélien, Viot, Geraldine, Brechard, Marie Pierre   +12 more
core   +1 more source

Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors

Frontiers in Bioscience-Landmark
Background: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: KRIT1 (CCM1), MGC4607 (CCM2 ...
Jacob Croft, Liyuan Gao, Victor Sheng, Jun Zhang   +3 more
doaj   +1 more source

A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

Nature Communications, 2019
Cerebral Cavernous Malformations (CCM) are often caused by mutations in CCM1/KRIT1. Here, Chapman et al. elegantly show that the CCM complex promotes apoptosis by regulating zinc homeostasis and storage via a conserved mechanism that likely generates the
Eric M. Chapman, Benjamin Lant, Yota Ohashi, Bin Yu, Michael Schertzberg, Christopher Go, Deepika Dogra, Janne Koskimäki, Romuald Girard, Yan Li, Andrew G. Fraser, Issam A. Awad, Salim Abdelilah-Seyfried, Anne-Claude Gingras, W. Brent Derry   +14 more
doaj   +1 more source

Novel Pathogenic Variants in a Cassette Exon of CCM2 in Patients With Cerebral Cavernous Malformations

Frontiers in Neurology, 2019
Autosomal dominant cerebral cavernous malformation (CCM) represents a genetic disorder with a high mutation detection rate given that stringent inclusion criteria are used and copy number variation analyses are part of the diagnostic workflow. Pathogenic
Christiane D. Much, Konrad Schwefel, Dariush Skowronek, Loay Shoubash, Felix von Podewils, Miriam Elbracht, Stefanie Spiegler, Ingo Kurth, Agnes Flöel, Henry W. S. Schroeder, Ute Felbor, Matthias Rath   +11 more
doaj   +1 more source

Loss of flavonol 3‐O‐glucosyltransferase activity confers soybean resistance to leaf‐chewing insects

The Plant Journal, Volume 126, Issue 1, April 2026.
Significance Statement The loss of flavonol 3‐O‐glucosyltransferase activity in soybean reduces feeding damage from defoliating insects and is accompanied by a concomitant increase in proanthocyanidins (red arrowhead). Unraveling the biochemical and genetic basis of soybean resistance to leaf‐chewing insects facilitates the development of new ...
P. K. Prabhakar, M. A. Ortega, B.‐K. Ha, P. R. LaFayette, S. A. Harding, C. J. Tsai, B. R. Urbanowicz, H. R. Boerma, W. A. Parrott   +8 more
wiley   +1 more source