Results 41 to 50 of about 4,207 (232)

Role of pericytes in the development of cerebral cavernous malformations

iScience, 2022
Summary: Cerebral cavernous malformation (CCM) is caused by loss-of-function mutations in CCM1, CCM2, or CCM3 genes of endothelial cells. It is characterized by pericyte deficiency. However, the role of pericytes in CCMs is not yet clarified.
Zifeng Dai, Jingwei Li, Ying Li, Rui Wang, Huili Yan, Ziyu Xiong, Shiting Wu, Xi Yang, Dongbo Lu, Dongdong Zhang, Guofu Li, Yuwen Wang, Chunyang Men, Wenzhong Du, Xiangjian Zheng, Changbin Shi   +15 more
doaj   +1 more source

KLF4 is a key determinant in the development and progression of cerebral cavernous malformations

EMBO Molecular Medicine, 2015
Cerebral cavernous malformations (CCMs) are vascular malformations located within the central nervous system often resulting in cerebral hemorrhage. Pharmacological treatment is needed, since current therapy is limited to neurosurgery.
Roberto Cuttano, Noemi Rudini, Luca Bravi, Monica Corada, Costanza Giampietro, Eleanna Papa, Marco Francesco Morini, Luigi Maddaluno, Nicolas Baeyens, Ralf H Adams, Mukesh K Jain, Gary K Owens, Martin Schwartz, Maria Grazia Lampugnani, Elisabetta Dejana   +14 more
doaj   +1 more source

FAIRE-seq data analysis of Chlamydomonas reinhardtii under carbon deprivation [PDF]

, 2012
For the genome-wide identification of nucleosome depleted regions under carbon deprivation, we analyze an available set of data from an assay of formaldehyde-assisted isolation of regulatory elements followed by sequencing (FAIRE-seq).
Bernd Mü, David Urbina-Gó, Diego Mauricio Riañ, Flavia Vischi Winck   +3 more
core   +2 more sources

Familial cerebral cavernous malformations: Rio de Janeiro study and review of the recommendations for management Malformação cavernosa cerebral familiar: um estudo no Rio de Janeiro e revisão das recomendações para tratamento

Arquivos de Neuro-Psiquiatria, 2008
OBJECTIVE: Multiple cerebral cavernous malformation (CCM) is the hallmark of familial presentation of cavernous malformation in the brain. We describe an ongoing Familial Cerebral Cavernous Malformation Project in the Rio de Janeiro state showing genetic
Flávio Domingues, Emerson L. Gasparetto, Ricardo Andrade, Fabio Noro, Antônio Eiras, Judith Gault, Carlos Eduardo Silva Correia, Jorge Marcondes de Souza   +7 more
doaj   +1 more source

A novel insight into differential expression profiles of sporadic cerebral cavernous malformation patients with different symptoms

Scientific Reports, 2021
Cerebral cavernous malformation (CCM) is a vascular lesion of the central nervous system that may lead to distinct symptoms among patients including cerebral hemorrhages, epileptic seizures, focal neurologic deficits, and/or headaches.
Hilal Eren Gozel, Kıvanç Kök, Fatma Ozlen, Cihan Isler, Sadrettin Pence   +4 more
doaj   +1 more source

The effect of different hydration media on magnesia

Discover Materials, 2021
This paper discusses the rate of hydration of magnesia (CCM1 and CCM2) during the formation of magnesium hydroxide with magnesium acetate and distilled water.
Friedrich von Hoessle, Reham Farid, Mayar Mohamed, Rawia M. Hammouda, Fritz E. Kühn, Ghada Bassioni   +5 more
doaj   +1 more source

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. [PDF]

, 2016
Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development.
de Kreuk, Bart-Jan, Gingras, Alexandre R, Gingras, Anne-Claude, Ginsberg, Mark H, Knight, James Dr, Liu, Jian J   +5 more
core   +2 more sources

Molecular diagnosis in cerebral cavernous malformations

Neurología (English Edition), 2017
Introduction: Cerebral cavernous malformations (CCMs; OMIM 116860) are enlarged vascular cavities without intervening brain parenchyma whose estimated prevalence in the general population is between 0.1% and 0.5%.
R. Mondejar, M. Lucas
doaj   +1 more source

Molecular Genetic Features of Cerebral Cavernous Malformations (CCM) Patients: An Overall View from Genes to Endothelial Cells

Cells, 2021
Cerebral cavernous malformations (CCMs) are vascular lesions that affect predominantly microvasculature in the brain and spinal cord. CCM can occur either in sporadic or familial form, characterized by autosomal dominant inheritance and development of ...
Giulia Riolo, Claudia Ricci, Stefania Battistini   +2 more
doaj   +1 more source

Diagnóstico molecular de cavernomatosis cerebral

Neurología, 2017
Resumen: Introducción: Las malformaciones cavernosas cerebrales (CCM; OMIM 116860) son engrosamientos cavernosos vasculares sin intervención del parénquima cerebral con una prevalencia estimada en la población general del 0,1-0,5%.
R. Mondejar, M. Lucas
doaj   +1 more source