Results 51 to 60 of about 4,207 (232)

A Novel CCM2 Gene Mutation Associated With Cerebral Cavernous Malformation

Frontiers in Neurology, 2020
Cerebral cavernous malformations (CCMs) are the second most prevalent type of vascular malformation within the central nervous system. CCMs occur in two forms—sporadic and familial—the latter of which has an autosomal dominant mode of inheritance with ...
Lipeng Yang, Jian Wu, Jing Zhang
doaj   +1 more source

Oscillatory contractile forces refine endothelial cell-cell interactions for continuous lumen formation governed by Heg1/Ccm1

Angiogenesis
The formation and organization of complex blood vessel networks rely on various biophysical forces, yet the mechanisms governing endothelial cell-cell interactions under different mechanical inputs are not well understood.
Jianmin Yin, Ludovico Maggi, Cora Wiesner, Markus Affolter, H. Belting   +4 more
semanticscholar   +1 more source

Yeast pentatricopeptide protein Dmr1 (Ccm1) binds a repetitive AU-rich motif in the small subunit mitochondrial ribosomal RNA

RNA: A publication of the RNA Society, 2020
PPR proteins are a diverse family of RNA binding factors found in all Eukaryotic lineages. They perform multiple functions in the expression of organellar genes, mostly on the post-transcriptional level.
J. Piątkowski, P. Golik
semanticscholar   +1 more source

Subjective Cognitive Concerns and Attitudes toward Genetic Testing Are Associated with Depressive Symptoms and Quality of Life after Genetic Testing for the Cerebral Cavernous Malformation Common Hispanic Mutation (CCM1)

Journal of Behavioral and Brain Science, 2020
Purpose This study aimed to characterize mood and quality of life and to examine the associations of these areas with subjective cognitive concerns and attitudes toward genetic testing for the Common Hispanic Mutation, a gene that has been associated ...
Richard A. Campbell, C. Petranovich, Savannah R Cheek, L. Morrison, B. Hart   +4 more
semanticscholar   +1 more source

Multidrug-Loaded Lipid Nanoemulsions for the Combinatorial Treatment of Cerebral Cavernous Malformation Disease

Biomedicines, 2023
Cerebral cavernous malformation (CCM) or cavernoma is a major vascular disease of genetic origin, whose main phenotypes occur in the central nervous system, and is currently devoid of pharmacological therapeutic strategies.
Andrea Perrelli, Annalisa Bozza, Chiara Ferraris, Sara Osella, Andrea Moglia, Silvia Mioletti, Luigi Battaglia, Saverio Francesco Retta   +7 more
doaj   +1 more source

Maltese study of intracranial vascular malformations [PDF]

, 2018
Intracranial vascular malformations (IVMs) are responsible for 49% of spontaneous intraparenchymal brain haemorrhage in patients under 40 years of age.
Chircop, Charmaine, Dalli, Theresia, Mallia, Maria   +2 more
core   +1 more source

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

Heliyon, 2019
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel, Mariana Vasquez, Brian Grajeda, Cameron Ellis, Jun Zhang   +4 more
doaj   +1 more source

Pyrenoid loss impairs carbon-concentrating mechanism induction and alters primary metabolism in Chlamydomonas reinhardtii [PDF]

, 2017
Carbon-concentrating mechanisms (CCMs) enable efficient photosynthesis and growth in CO2-limiting environments, and in eukaryotic microalgae localisation of Rubisco to a microcompartment called the pyrenoid is key.
Madeline C Mitchell, Gergana Metodieva, Metodi V Metodiev, Howard Griffiths, Moritz T Meyer, Badger, Borkhsenious, Brueggeman, Caspari, Chen, Dionisio-Sese, Eriksson, Falda, Fang, Fukuzawa, Genkov, Giordano, Goodstein, Hochmal, Horton, Im, Jin, Karlsson, Karpievitch, Kelley, Kim, Krogh, Kropat, Lavigne, Lohse, Ma, Mackinder, McKew, Metodieva, Meyer, Mitchell, Miura, Morita, Moroney, Moroney, Raven, Reinfelder, Schloss, Schulze, Spalding, Spalding, Spalding, Spalding, Spalding, Spreitzer, Tardif, Tavío, Villarejo, Wang, Wang, Wang, Wang, Yamano, Yamano, Yamano, Zones   +60 more
core   +1 more source

CCM1–ICAP-1 complex controls β1 integrin–dependent endothelial contractility and fibronectin remodeling [PDF]

Journal of Cell Biology, 2013
The endothelial CCM complex regulates blood vessel stability and permeability. Loss-of-function mutations in CCM genes are responsible for human cerebral cavernous malformations (CCMs), which are characterized by clusters of hemorrhagic dilated capillaries composed of endothelium lacking mural cells and altered sub-endothelial extracellular matrix (ECM)
Faurobert, Eva, Rome, Claire, Lisowska, Justyna, Manet-Dupé, Sandra, Boulday, Gwénola, Malbouyres, Marilyne, Balland, Martial, Bouin, Anne-Pascale, Kéramidas, Michelle, Bouvard, Daniel, Coll, Jean-Luc, Ruggiero, Florence, Tournier-Lasserve, Elisabeth, Albiges-Rizo, Corinne   +13 more
openaire   +3 more sources

Proteomic Analysis of High-CO2-Inducible Extracellular Proteins in the Unicellular Green Alga, Chlamydomonas reinhardtii [PDF]

, 2011
The unicellular green alga Chlamydomonas reinhardtii can acclimate to a wide range of CO2 concentrations through the regulation of a CO2-concentrating mechanism (CCM).
Baba Masato, Shiraiwa Yoshihiro, Suzuki Iwane, 白岩 善博, 鈴木 石根, 馬場 将人   +5 more
core   +1 more source