Results 81 to 90 of about 4,207 (232)

A novel CCM2 variant in a family with non-progressive cognitive complaints and cerebral microbleeds [PDF]

, 2017
Lobar cerebral microbleeds are most often sporadic and associated with Alzheimer's disease. The aim of our study was to identify the underlying genetic defect in a family with cognitive complaints and multiple lobar microbleeds and a positive family ...
Barkhof, F. (Frederik), Cohn-Hokke, P.E. (P.), Flier, W.M. (Wiesje) van der, Holstege, H. (Henne), Meijers-Heijboer, E.J. (Hanne), Pijnenburg, Y.A.L. (Yolande), Scheltens, P. (Philip), Sistermans, E.A. (Erik), Swieten, J.C. (John) van, Weiss, M.M. (Marjan M.)   +9 more
core   +1 more source

CELS‐3D—Cutting edge light source for exciting fluorescence in microtome‐based 3D microscopy and targeted correlative microscopy

Journal of Anatomy, Volume 246, Issue 5, Page 782-797, May 2025.
A working prototype of a novel 3D fluorescent microscope, designated CELS‐3D (Cutting Edge Light Source, Three‐Dimensional), was constructed and the proof of principle demonstrated. The light originating from the cutting edge of the glass knife forms a kind of light sheet suitable for fluorescence excitation and 3D imaging of fluorescent samples.
Vladyslav Denyshchenko, Christopher Evans, Tiina O'Neill, Jakub Krstev, Emilia Filipczak, Silas O'Toole, Vladimir Lobaskin, Dimitri Scholz   +7 more
wiley   +1 more source

Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling [PDF]

Proceedings of the National Academy of Sciences, 2010
Cerebral cavernous malformations (CCM) are frequent vascular abnormalities caused by mutations in one of the CCM genes. CCM1 (also known as KRIT1) stabilizes endothelial junctions and is essential for vascular morphogenesis in mouse embryos.
Wüstehube, Joycelyn, Fischer, Andreas, Augustin, Hellmut, Sure, Ulrich, Felbor, Ute, Zhu, Yuan, Brütsch, Rene, Liebler, Sven S., Bertol, Arne   +8 more
openaire   +2 more sources

Familiäre Kavernome des Zentralnervensystems: Eine klinische und genetische Studie an 15 deutsche Familien [PDF]

, 2018
Zusammenfassung: 1928 beschrieb Hugo Friedrich Kufs erstmalig eine Familie mit zerebralen, retinalen und kutanen Kavernomen. Mittlerweile wurden über 300 weitere Familien beschrieben.
Andermann, E., Andermann, F., Baumann, C., Bertalanffy, H., Dichgans, J., Elger, C., Hopf, H., Hopf, N., Keidel, M., Kleider, A., Nowak, G., Pfeiffer, R., Rouleau, G., Schramm, J., Siegel, A., Spuck, S., Stefan, H., Sure, U., Verlaan, D.   +18 more
core  

Periodic Light Modulations for Low‐Cost Wide‐Field Imaging of Luminescence Kinetics Under Ambient Light

Advanced Science, Volume 12, Issue 10, March 13, 2025.
Imaging fast luminescence kinetics has required costly camera setups. The RIOM and HIOM protocols relying on modulated illumination are introduced to make this possible with standard low‐cost cameras, even under ambient light. These are implemented to measure the photoactivation time of a reversibly photoswitchable protein and microsensors and recover ...
Hélène Merceron, Ian Coghill, Aliénor Lahlou, Marie‐Aude Plamont, Ludovic Jullien, Thomas Le Saux   +5 more
wiley   +1 more source

Birth of Cities: Division of Labor and Transportation Costs [PDF]

, 2014
In this paper, we constructs a model with two-region, two sector and two types of workers. One type of workers has a comparative advantage in agricultural production and mobile between two regions, while the other type of workers has a comparative ...
morita, tadashi, yamamoto, kazuhiro
core  

Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature [PDF]

, 2015
BACKGROUND: Small GTPase Rap1 has been implicated in a number of basic cellular functions, including cell-cell and cell-matrix adhesion, proliferation and regulation of polarity.
Chrzanowska-Wodnicka, Magdalena, Quilliam, Lawrence A., White, Gilbert C., Whitehead, Kevin J.   +3 more
core   +2 more sources

Transfer morphological features for segmentation with few labels on fluorescent mitochondria images

IET Image Processing, Volume 19, Issue 1, January/December 2025.
Deep learning‐based approaches have demonstrated promising performance; however, the scarcity of labeled mitochondrial data presents a significant challenge. To address this, we propose a high‐precision segmentation framework leveraging inductive transfer learning.
Tianyi Zhang, Junchao Fan, Xiuli Bi, Weisheng Li, Bin Xiao, Xiaoshuai Huang   +5 more
wiley   +1 more source

ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis.

PLoS ONE, 2015
Cerebral cavernous malformations are fragile blood vessel conglomerates in the central nervous system that are caused by mutations in the CCM1/KRIT1, CCM2 or CCM3 genes.
Stefanie E Herberich, Ralph Klose, Iris Moll, Wan-Jen Yang, Joycelyn Wüstehube-Lausch, Andreas Fischer   +5 more
doaj   +1 more source

GERM-LINE/SOMATIC DNA COMPARISON IN SPORADIC PATIENTS WITH CEREBRAL CAVERNOUS MALFORMATIONS.

Euromediterranean Biomedical Journal, 2017
Cerebral cavernous malformations (CCMs) are benign tumours that affect brain capillaries. Although many cases remain asymptomatic, their incidence is steadily increasing.
Ivan Anchesi
doaj   +1 more source