Results 221 to 230 of about 37,429 (252)

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2021
Aims. The rate of progression of HIV-1 disease exhibits a remarkable variation among different individuals. Several natural polymorphisms in the genes for the human CC-chemokine receptors CCR5 and CCR2 are associated with HIV-1 disease. associated with a delayed progression to disease.
openaire   +1 more source

PCSK9 regulates the chemokine receptor CCR2 on monocytes

Biochemical and Biophysical Research Communications, 2017
Monocyte migration is a key element in atherosclerosis. LDL-C facilitates monocyte migration via induction of CCR2. PCSK9 regulates cell surface expression of the LDL-R and is expressed in vascular smooth muscle cells (VSMCs). The present study was done to investigate the regulation of PCSK9 in VSMCs and its impact on monocyte function.PCSK9 mRNA and ...
Jana, Grune, Heike, Meyborg, Taisiya, Bezhaeva, Kai, Kappert, Philipp, Hillmeister, Ulrich, Kintscher, Burkert, Pieske, Philipp, Stawowy   +7 more
openaire   +2 more sources

CCR5 and CCR2 gene polymorphisms in hypertensive patients

British Journal of Biomedical Science, 2003
Essential hypertension is a complex trait under polygenic control. Evidences suggests immune system involvement during pathogenesis. CC-chemokine receptor (CCR)5 and CCR2 are characterised by gene polymorphism. Variant alleles are derived from a deletion in the CCR5 gene (CCR5delta32) and a substitution mutation at the CCR2 locus (CCR264I).
M, Mettimano, M L, Specchia, A, Ianni, D, Arzani, G, Ricciardi, L, Savi, V, Romano-Spica   +6 more
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CCL2/CCR2 signaling pathway in glioblastoma multiforme

Neurochemistry International, 2017
Glioblastoma multiform (GBM) is described as one of the most frequent primary brain tumors. These types of malignancies constitute only 15% of all primary brain tumors. Despite, extensive developments on effective therapeutic methods during the 20th century as well as the first decade of the present century (21st), the median survival rate for patients
Alireza, Vakilian, Hossein, Khorramdelazad, Parisa, Heidari, Zahra, Sheikh Rezaei, Gholamhossein, Hassanshahi   +4 more
openaire   +2 more sources

Substituted dipiperidine alcohols as potent CCR2 antagonists

Bioorganic & Medicinal Chemistry Letters, 2008
The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC(50) values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.
Mingde, Xia, Cuifen, Hou, Duane, Demong, Scott, Pollack, Meng, Pan, James, Brackley, Monica, Singer, Michele, Matheis, Druie, Cavender, Michael, Wachter   +9 more
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Small molecule CCR2 antagonists

2007
Monocyte chemoattractant protein-1 (MCP-1), also known as CCL2, is a member of the CC family of chemokines. During inflammatory conditions, the production of MCP-1 is upregulated in both immune and non-immune cell types including macrophages, mast cells, fibroblasts, endothelial and epithelial cells, smooth muscle cells, and astrocytes.
Paul J. Higgins, C. Eric Schwartz, Jean-Marie Nicolas   +2 more
openaire   +1 more source

In vivo activity of an azole series of CCR2 antagonists

Bioorganic & Medicinal Chemistry Letters, 2012
Optimisation of a series of biaryl sulphonamides resulted in the identification of compound 14 [corrected] which demonstrated dose-dependent and strain-specific inhibition of monocyte recruitment in a thioglycollate-induced peritonitis model of inflammation. [Formula: see text]. [corrected].
Chris A, Smethurst, Nicola, Bevan, Carl, Brooks, Amanda, Emmons, Peter J, Gough, Claudette, Mookherjee, Kitty, Moores, Simon, Peace, Joanne, Philp, Val, Piercy, Steve P, Watson, Mara, Zippoli   +11 more
openaire   +2 more sources

Functional expression of CCR2 by human fetal astrocytes

Journal of Neuroscience Research, 2002
AbstractAstrocytes from different sources bind the chemokine monocyte chemoattractant factor (MCP‐1), yet functional expression in these cells of CCR2, the major receptor for this ligand, has been a matter of controversy. Here we show that cultured human fetal astrocytes express CCR2 at the mRNA and protein levels, and display chemotaxis and calcium ...
Anuska V, Andjelkovic, Li, Song, Kirk A, Dzenko, Hui, Cong, Joel S, Pachter   +4 more
openaire   +2 more sources

Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications

Frontiers in Immunology, 2022
Yunqing Hua, Fan Guanwei, Jingyu Ni
exaly  

CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation

Journal of Controlled Release, 2021
Noah Trac, Ailin Zhang, Chun-Peng Liao   +2 more
exaly