Results 71 to 80 of about 6,286 (187)

HIV-1 subtype C predicted co-receptor tropism in Africa: an individual sequence level meta-analysis

AIDS Research and Therapy, 2020
Background Entry inhibitors, such as Maraviroc, hold promise as components of HIV treatment and/or pre-exposure prophylaxis in Africa. Maraviroc inhibits the interaction between HIV Envelope gp120 V3-loop and CCR5 coreceptor. HIV-1 subtype C (HIV-1-C) is
Nontokozo D. Matume, Denis M. Tebit, Pascal O. Bessong   +2 more
doaj   +1 more source

QSAR Study on Novel CCR5 Receptor Antagonists: An Insight into the Structural Requirement for the HIV Co Receptor Antagonist Activity [PDF]

Scientia Pharmaceutica, 2008
Chemokines receptors have emerged as important drug targets for development of agents against the HIV/AIDS pandemic. With the purpose of designing new chemical entities with enhanced antagonistic potencies against the CCR5 chemokine receptor, the QSAR study carried out on 70 novel phenoxybenzyl derivatives as antagonists of CCR5 HIV co receptor is ...
openaire   +1 more source

The chemokine receptor‐like fourth extracellular loop of the apelin receptor differentially regulates apelin and elabela binding and signalling

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Apelin and Elabela are endogenous ligands of the apelin receptor (apelin receptor/APJ), a GPCR involved in cardiovascular regulation and body fluid homeostasis. The human receptor contains a conserved disulfide bridge linking the N‐terminal domain to extracellular loop 3 (ECL3) via Cys19 and Cys281, forming a structural ...
Chloé Bonef, Hela Bouhsine, Carine Huynh, Marion Chaigneau, Steven Dubois, Mikel Garcia‐Marcos, Catherine Llorens‐Cortes, Denis Servent, Philippe Robin, Hervé Nozach, Isabel Alves, Xavier Iturrioz   +11 more
wiley   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation

Cogent Medicine, 2017
Most HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of ...
Alexey Lopatukhin, Dmitry Kireev, Dmitry Kuevda, Anastasia Pokrovskaya, Galina Tsyganova, Galina Korovina, Alexander Pinsker, Natalia Dementeva, Natalia Sizova, Olga Peksheva, Natalia Zaytseva, Nikolai Nosov, Nail Urazov, Valery Gerasimov, Natalia Ermolinskaya, Natalia Gerasimova, Tatyana Sandyreva, Ludmila Volova, Lilia Grezina, Anna Kolomeets, Irina Sergeeva, Dmitry Neshumaev, Anatoly Boyko, Valeria Kotova, Ludmila Balakhontseva, Dmitry Kolpakov, Andrey Shemshura, Sergey Saukhat, Evgeniy Bukin, Andrey Polyakov, Rolf Kaiser, German Shipulin, Vadim Pokrovsky   +32 more
doaj   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Cloning and functional characterization of the rabbit C-C chemokine receptor 2

BMC Immunology, 2005
Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-borne monocytes to sites of inflammation and is implicated in the pathogenesis of several inflammatory diseases such as rheumatoid arthritis, multiple sclerosis ...
Hamdouchi Chafiq, Su Eric W, Wang He, Pappas Amy T, Evans Robert J, Yuan Xiu-juan, Lu Deshun, Venkataraman Chandrasekar   +7 more
doaj   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Treatment With Ruxolitinib and TAK‐779 Enhances GII.17 Human Norovirus Replication and Enables Serial Passaging in Human Intestinal Enteroids

Genes to Cells, Volume 31, Issue 5, September 2026.
We aimed to establish a simple method for GII.17 human norovirus (HuNoV) replication and serial passaging using wild‐type J2 human intestinal enteroids (HIEs). Treatment with ruxolitinib and TAK‐779, which target interferon and chemokine signaling, respectively, enhances viral replication and enables serial passaging of GII.17. ABSTRACT Human norovirus
Eri Hiraishi, Tsuyoshi Hayashi, Yoshiki Fujii, Hirokazu Kimura, Kosuke Murakami   +4 more
wiley   +1 more source