Results 41 to 50 of about 626,416 (244)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Yankuang ceshi, 2014 The traditional solid phase extraction sorbent contains certain deficiencies in the progress of processing heavy metals in environmental samples, such as pH instability and co-extraction difficulty.
SUN Na +3 more
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Astronomy & AstrophysicsWe investigated the stellar velocity dispersion functions (VDFs) of pressure-supported galaxies in the EAGLE cosmological simulations. The central stellar velocity dispersion is one of the fundamental dynamical tracers of the total mass of galaxy ...
Choi Jungwon, Sohn Jubee
doaj +1 more source
Yankuang ceshi, 2019 BACKGROUND Traditional inductively coupled plasma-mass spectrometry (ICP-MS) determination of trace elements such as Ag and Cd in geochemical samples is seriously affected by the matrix effect and multiple polyatomic ions, making it difficult to measure ...
XU Jin-li +6 more
doaj +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Effects of pH on MICP curing of cadmium-contaminated tailings
Yantu gongcheng xuebaoThe microbial induced calcium carbonate precipitation (MICP) method is regarded as an environmentally sustainable approach for the solidification and remediation of contaminated soils.
JIANG Zhaoming1 , CHEN Yonggui1 , WEN Zihao1, FU Jun1, 2, ZHOU Han2
doaj +1 more source
Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz +25 more
wiley +1 more source
Labile Cd Complexes Increase Cd Availability to Plants [PDF]
Environmental Science & Technology, 2005 Dissolved trace metals are present in the environment as free ions and as complexes. Commonly used models to predict metal bioavailability consider the free ion as the major bioavailable species. However, increases in metal availability in the presence of metal complexes have repeatedly been found.
Degryse, Fien +2 more
openaire +3 more sources