Results 151 to 160 of about 33,329 (197)

Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells [PDF]

open access: yesOncogene, 2008
The cancer stem cell hypothesis posits that malignant growth arises from a rare population of progenitor cells within a tumor that provide it with unlimited regenerative capacity. Such cells also possess increased resistance to chemotherapeutic agents. Resurgence of chemoresistant disease after primary therapy typifies epithelial ovarian cancer and may
Susan K. Murphy, Eiji Kondo, R C Bentley
exaly   +3 more sources

Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas [PDF]

open access: yesLaboratory Investigation, 2008
A number of recent reports have demonstrated that only CD133-positive cancer cells of glioblastoma multiforme (GBM) have tumor-initiating potential. These findings raise an attractive hypothesis that GBMs can be cured by eradicating CD133-positive cancer stem cells (CSCs), which are a small portion of GBM cells.
Xun Jin, Do-Hyun Nam, Kyeung Min Joo
exaly   +3 more sources
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Differential characteristics of CD133+ and CD133− Jurkat cells

In Vitro Cellular & Developmental Biology - Animal, 2015
T cell acute lymphoblastic leukemia (T-ALL) is a hematological disease including malignancy of T cell precursors. There are some T-ALL patients that are drug-resistant. A major cause of treatment failure in cancers can be associated with the existence of cancer stem cells.
Azadeh, Anbarlou   +5 more
openaire   +2 more sources

Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133− cells, and the CD133+ sector is enlarged by hypoxia

International Journal of Radiation Oncology Biology Physics, 2007
Primary medulloblastoma and glioblastoma multiforme tumor cells that express the surface marker CD133 are believed to be enriched for brain tumor stem cells because of their unique ability to initiate or reconstitute tumors in immunodeficient mice. This study sought to characterize the radiobiological properties and marker expression changes of CD133 ...
Ed R, Blazek   +2 more
exaly   +3 more sources

Expression of CD133–1 and CD133–2 in ovarian cancer

International Journal of Gynecological Cancer, 2008
Cancer stem cells have been isolated from several solid tumors including prostate, colon, liver, breast, and ovarian cancer. Stem cells isolated from nervous system and prostate express CD133 antigen, which is widely used to isolate hematopoietic stem and progenitor cells.
G. Ferrandina   +12 more
openaire   +3 more sources

CD133: molecule of the moment

The Journal of Pathology, 2007
AbstractCD133 (prominin‐1) was the first in a class of novel pentaspan membrane proteins to be identified in both humans and mice, and was originally classified as a marker of primitive haematopoietic and neural stem cells. Due to the highly restricted expression of CD133 family molecules on plasma membrane protrusions of epithelial and other cell ...
D, Mizrak, M, Brittan, M R, Alison
openaire   +2 more sources

Expression of CD133 in Synovial Sarcoma

Applied Immunohistochemistry & Molecular Morphology, 2010
The development of synovial sarcoma, a translocationally defined soft tissue tumor of unknown histogenesis with considerable resistance to systemic therapy and a poor prognosis, may involve cancer stem-like cells. Recent studies suggest that synovial sarcoma arises from a primitive progenitor-type cell and have shown that synovial sarcomas contain ...
Jefferson, Terry, Torsten, Nielsen
openaire   +2 more sources

CD133 and FGF7

Egyptian Journal of Pathology, 2012
Background In chronic inflammation, an active interplay between cancer stem cells (CSCs) and the tumor microenvironment including carcinoma-associated fibroblasts (CAFs) has emerged as a necessary mechanism of carcinogenesis. However, the precise molecular events remain unclear.
Rasha M. Abd El Atti, Riham M. Abu-Zeid
openaire   +1 more source

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