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Targeting CD133 antigen in cancer
Expert Opinion on Therapeutic Targets, 2009Much attention has been focused on CD133 as a marker of cancer cells with stem-cell-like ability. In the cancer stem cells (CSCs) model, only a small proportion of tumour cells are able to self-renew extensively, while the bulk of cells proceed to differentiate into committed heterogeneous clones.
Ferrandina G. +3 more
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CD133 expression in colorectal adenomas
Journal of Clinical Pathology, 2013We have read with great interest the recent publication on the stem cell marker CD133 and serrated and hyperplastic intestinal polyps by Mohammadi et al. 1 Although adenomas are the most frequent type of benign colorectal polyp, there are limited published data on CD133 expression.2 ,3 We examined the patterns of CD133 expression by ...
Adriana, Handra-Luca, Sarah, Taconet
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Expression of CD133 in acute leukemia
Medical Oncology, 2013There have been conflicting results regarding a correlation between CD133 expression and disease outcome. To assess CD133 expression in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) and to evaluate its correlation with the different clinical and laboratory data as well as its relation to disease outcome, the present ...
Fetnat M, Tolba +3 more
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CD133 as a target for colon cancer
Expert Opinion on Therapeutic Targets, 2012Recent evidence based on cancer stem cell (CSC) models, is boosting the progress of translational research and providing relevant clinical implications in many tumour types, including colorectal cancer. The current failure of standard therapies is attributed to a small fraction of the primary cell population with stem-like characteristics, such as self-
CATALANO, Veronica +5 more
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The International Journal of Biochemistry & Cell Biology, 2005
Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133).
Sergey V, Shmelkov +3 more
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Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133).
Sergey V, Shmelkov +3 more
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Comparative Gene-Expression Profiling of CD133 + and CD133 - D10 Melanoma Cells
Future Oncology, 2015The present study aimed to compare the gene-expression profiling of CD133(+) and CD133(-) D10 cells.Cancer stem cell-like properties and gene-expression profiling of CD133(+) D10 cells versus CD133(-) cells were evaluated.The CD133(+) D10 cells showed significantly higher clonogenic and spheroid forming potential, also higher expression of stemness ...
Raheleh, Roudi +8 more
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Cell cycle analysis of the CD133+ and CD133− cells isolated from umbilical cord blood
Clinica Chimica Acta, 2004Umbilical cord blood cells (stem/progenitor cells) exhibit high proliferative capacities leading to a large expansion of cells in appropriate cell culture conditions. The aim of this study was to evaluate by flow cytometry the cycling status of CD133+ and CD133- cells depending on various culture conditions, such as sera, stem cell factor (SCF ...
Gršković, Branka +4 more
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Cytotherapy, 2012
Umbilical cord blood (UCB) is a rich source of stem cells, the characterization and isolation of which requires specific stem cell markers and reliable and reproducible protocols.We assessed CD133 isolation in 39 UCB samples, using a commercial immunomagnetic cell-sorting protocol, and, because of its non-reproducibility, we applied optimized protocols
Iordanis, Pelagiadis +3 more
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Umbilical cord blood (UCB) is a rich source of stem cells, the characterization and isolation of which requires specific stem cell markers and reliable and reproducible protocols.We assessed CD133 isolation in 39 UCB samples, using a commercial immunomagnetic cell-sorting protocol, and, because of its non-reproducibility, we applied optimized protocols
Iordanis, Pelagiadis +3 more
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Expression profiling of CD133+ and CD133— epithelial cells from human prostate
The Prostate, 2008AbstractBACKGROUNDRecent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized. The aim of our study was to gene expression profile CD133‐expressing cells.METHODSWe analyzed CD133‐positive (CD133+) and ‐negative (CD133−) sub‐populations of high ...
Shepherd, Christopher J +7 more
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Expression and regulation of AC133 and CD133 in glioblastoma
Glia, 2011AbstractThe biological significance of CD133 in glioblastoma is controversial. Above all, there is disagreement concerning the proper approach, the appropriate (cell) model and the suitable microenvironment to study this molecule, often leading to inconsistent experimental results among studies.
Benito, Campos +6 more
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