Results 41 to 50 of about 19,801 (209)

TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

Frontiers in Immunology, 2011
Plasma cells have a heterogeneous phenotype in humans. While bone marrow plasma cells are CD20-CD138+, tonsil plasma cells are CD20+CD138+/- and peripheral plasmablasts are CD20-CD138-.
Alexandrine eGeffroy-Luseau, Alexandrine eGeffroy-Luseau, David eChiron, David eChiron, Géraldine eDescamps, Géraldine eDescamps, Gaëtan eJégo, Gaëtan eJégo, Martine eAmiot, Martine eAmiot, Catherine ePellat-Deceunynck, Catherine ePellat-Deceunynck   +11 more
doaj   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

A functional screen of RNA binding proteins identifies genes that promote or limit the accumulation of CD138+ plasma cells

eLife, 2022
To identify roles of RNA binding proteins (RBPs) in the differentiation or survival of antibody secreting plasma cells we performed a CRISPR/Cas9 knockout screen of 1213 mouse RBPs for their ability to affect proliferation and/or survival, and the ...
David J Turner, Alexander Saveliev, Fiamma Salerno, Louise S Matheson, Michael Screen, Hannah Lawson, David Wotherspoon, Kamil R Kranc, Martin Turner   +8 more
doaj   +1 more source

Characterization of potential CD138 negative myeloma "stem cells"

Haematologica, 2012
Syndecan-1 is a heparan sulfate proteoglycan expressed by both normal and multiple myeloma (MM) plasma cells. Matsui et al. [1][1] reported the identification of a potential MM “stem cell” resembling less differentiated post germinal center B cells.
Christensen, Jacob H, Jensen, Pia V, Kristensen, Ida B, Abildgaard, Niels, Lodahl, Marianne, Rasmussen, Thomas   +5 more
openaire   +3 more sources

Automated B‐cell and plasma cell identification using unsupervised clustering by FlowSOM and an excel‐based classification model

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Manual gating for plasma cell (PC) identification in multiparametric flow cytometry (MFC) is time‐consuming and operator‐dependent, especially when PCs are scarce. Artificial intelligence approaches such as unsupervised clustering (e.g., FlowSOM) map high‐dimensional data that still require expert interpretation.
Ethan James Gantana, Ernest Musekwa, Erica‐Mari Nell, Zivanai Cuthbert Chapanduka   +3 more
wiley   +1 more source

AI-algorithm training and validation for identification of endometrial CD138+ cells in infertility-associated conditions; polycystic ovary syndrome (PCOS) and recurrent implantation failure (RIF)

Journal of Pathology Informatics
Background: Endometrial CD138+ plasma cells serve as a diagnostic biomarker for endometrial inflammation, and their elevated occurrence correlates positively with adverse pregnancy outcomes.
Seungbaek Lee, Riikka K. Arffman, Elina K. Komsi, Outi Lindgren, Janette A. Kemppainen, Hanna Metsola, Henna-Riikka Rossi, Anne Ahtikoski, Keiu Kask, Merli Saare, Andres Salumets, Terhi T. Piltonen   +11 more
doaj   +1 more source

Selective Cytotoxicity of Single and Dual Anti-CD19 and Anti-CD138 Chimeric Antigen Receptor-Natural Killer Cells against Hematologic Malignancies

Journal of Immunology Research, 2021
Natural killer (NK) cells are part of the first line of defense that rapidly respond to malignant transformed cells. Chimeric antigen receptor- (CAR-) engineered NK cells, although are still at the preliminary stage, have been shown to be alternative to ...
Sudjit Luanpitpong, Jirarat Poohadsuan, Phatchanat Klaihmon, Surapol Issaragrisil   +3 more
doaj   +1 more source

Circulating human B and plasma cells. Age-associated changes in counts and detailed characterization of circulating normal CD138- and CD138+ plasma cells

Haematologica, 2010
Generation of B and plasma cells involves several organs with a necessary cell trafficking between them. A detailed phenotypic characterization of four circulating B-cell subsets (immature-, naïve-, memory- B-lymphocytes and plasma cells) of 106 healthy adults was realized by multiparametric flow cytometry.
Anouk Caraux, Bernard Klein, Bruno Paiva, Caroline Bret, Alexander Schmitz, Gwenny M. Fuhler, Nico A. Bos, Hans E Johnsen, Alberto Orfao, Martin Perez-Andres, for the Myeloma Stem Cell Network (MSCNET)   +10 more
openaire   +4 more sources

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Early differentiated CD138(high) MHCII+ IgG+ plasma cells express CXCR3 and localize into inflamed kidneys of lupus mice. [PDF]

PLoS ONE, 2013
Humoral responses are central to the development of chronic autoimmune diseases such as systemic lupus erythematosus. Indeed, autoantibody deposition is responsible for tissue damage, the kidneys being one of the main target organs.
Stéphanie Lacotte, Marion Decossas, Carole Le Coz, Susana Brun, Sylviane Muller, Hélène Dumortier   +5 more
doaj   +1 more source