Results 201 to 210 of about 131,028 (295)

Brain metastasis‐associated fibroblasts shape the tumour microenvironment to enhance cancer cell invasion

Brain Pathology, EarlyView.
Brain metastasis‐associated fibroblasts are active stromal components of the metastatic niche characterised by extracellular matrix remodelling and production of pro‐migratory mediators. They promote monocyte and cancer cell migration and enhance cancer cell invasion while having no growth‐promoting effect on cancer cells.
Barbora Výmolová, Lucie Pfeiferová, Tadeáš Karel Smetana, Petr Výmola, Nikola Ternerová, Michal Zubaľ, Michal Kolář, Jana Šáchová, Soňa Gyönyörová, Eva Balážiová, Magdalena Houdová Megová, Jakub Červenka, Helena Kupcová Skalníková, Michal Španko, Karel Smetana Jr., Lukáš Lacina, David Netuka, Robert Tomáš, Petr Bušek, Aleksi Šedo   +19 more
wiley   +1 more source

Redistribution of peripheral blood immune cell subsets and remodeling of intercellular communication in rare Behçet's disease: a single-cell transcriptomics study. [PDF]

Front Med (Lausanne)
Yang Y, Chen Y.
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

CD14+CD56+ Cell Is an Independent Regulatory Monocyte Subpopulation Increased in VKHS Patients Following Glucocorticoids Therapy. [PDF]

Invest Ophthalmol Vis Sci
Wang Z, Jiang H, Deng H, Huang F, Qu S, He S, Yu B, Ye T, Li Z.   +8 more
europepmc   +1 more source

Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli, Henryata E. Rozario, Victor Martinez, Zachary L. McAdams, Stephen A. Adkins, Aaron C. Ericsson, Yagna P. R. Jarajapu   +6 more
wiley   +1 more source

Coordinated dynamics of circulating neutrophils, regulatory T lymphocytes, myeloid derived suppressor cells and distinct granulocytic subsets reveal a complex immune network in metastatic colorectal cancer. [PDF]

Front Oncol
Zafeiriou Z, Koutoulaki A, Aggouraki D, Koinis F, Vardakis N, Voutsina A, Papadogiannaki K, Kotta K, Vetsika EK, Mavroudis D, Georgoulias V, Kotsakis A.   +11 more
europepmc   +1 more source

Atibuclimab (IC14) for Treatment of Acute Decompensated Heart Failure: A Phase Ib Pilot Study. [PDF]

JACC Basic Transl Sci
Abbate A, Golino M, Hogwood AC, Marchetta M, Lopez RI, Parker K, Kelly J, Canada JM, Farr L, West J, Kontos E, Federmann E, Priday A, Mezzaroma E, Toldo S, Agosti J, Ziegelaar BW, Appleby MW, Crowe D, Charmley P, Redlich G, Van Tassell B.   +21 more
europepmc   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Contribution of monocyte subpopulations to the pathogenesis and therapy outcome of type 1 diabetes management in pediatric patients. [PDF]

Front Immunol
Starosz A, Jamiołkowska-Sztabkowska M, Murawska S, Głowińska-Olszewska B, Bossowski A, Grubczak K.   +5 more
europepmc   +1 more source

Dendritic cell-based immunotherapy modulates the systemic inflammatory profile in a 4T1 breast cancer model. [PDF]

Explor Target Antitumor Ther
Dias TC, Vieira JF, Tostes K, Silva PB, Lopes AMM, Rebolho GK, Murta EFC, Arantes LMRB, Michelin MA.   +8 more
europepmc   +1 more source