Results 191 to 200 of about 131,028 (295)

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques. [PDF]

Cell Rep Med
Silva de Castro I, Rahman MA, Bissa M, Goldfarbmuren KC, Schifanella L, Sarkis S, N'guessan KF, Ma ZM, Gutowska A, Stamos JD, Doster MN, Woode EK, Smith JC, Kozlowski PA, Williams LD, McKinnon KM, Tomaras GD, Shen X, Montefiori DC, Santra S, Paquin-Proulx D, Maldarelli F, Cardozo T, Franchini G.   +23 more
europepmc   +1 more source

Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma

Allergy, EarlyView.
This study investigates the effect of mepolizumab on the proteomic and transcriptomic profile of blood eosinophils in SEA patients. Mepolizumab reduces the migratory capacity and effector‐related molecular signatures of circulating eosinophils in SEA patients.
Pablo Miguéns‐Suárez, Sara Vázquez‐Mera, Laura Martelo‐Vidal, Marina Blanco Aparicio, Uxío Calvo Álvarez, Coral González Fernández, Mar Mosteiro Añón, Dolores Corbacho Abelaira, Tamara Hermida Valverde, Christian Calvo Henríquez, Susana B. Bravo, Lena Uller, Juan J. Nieto‐Fontarigo, Francisco J. Salgado, Francisco J. González‐Barcala   +14 more
wiley   +1 more source

Longitudinal Monocyte Subset Dynamics as Biomarker in Adult Histiocytosis: Association With Mutational Status, Kinase Inhibitor Exposure and Relapse Risk. [PDF]

Hematol Oncol
Razanamahery J, Raymond C, Papo M, Pegoraro F, Guy J, Aho LS, Emile JF, Samson M, Audia S, Haroche J, Bonnotte B.   +10 more
europepmc   +1 more source

Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis

Allergy, EarlyView.
Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross, Lukas Bäriswyl, Erik Kupschke, Alexandra Wallimann, Hanne Hillen, Philipp Kirchner, Jivko Kamarashev, Martin Wartenberg, Claudio Rhyner, Christoph Schlapbach, Stephan Traidl, Mirjam Schenk   +11 more
wiley   +1 more source

Systemic-local immune remodeling in colorectal cancer: CD14+ cell-derived cytokine responsiveness, mucosal immune-cell organization, and exploratory metastasis-associated patterns. [PDF]

Front Immunol
Shakhpazyan NK, Mikhaleva LM, Sadykhov NK, Konyukova AK, Bedzhanyan AL, Gioeva ZV, Khrustaleva MV, Godzhello EA.   +7 more
europepmc   +1 more source

Predicted microbiome‐associated metabolic pathways are linked to immune checkpoint modulation in chronic lymphocytic leukaemia

British Journal of Haematology, EarlyView.
Summary Microbial metabolites are key regulators of host immunity, yet their functional impact in chronic lymphocytic leukaemia (CLL) remains unclear. Following up on our earlier observations of microbiome dysbiosis in CLL, we performed predictive metabolic profiling based on 16S ribosomal RNA (rRNA) sequencing of oral and stool samples collected from ...
Monika Szelest, Joanna Zaleska, Michał Kiełbus, Magdalena Paziewska, Marta Masternak, Ewa Wawrzyniak, Aleksandra Kotkowska, Monika Siemieniuk‐Ryś, Marta Morawska, Elżbieta Kalicińska, Paula Jabłonowska‐Babij, Tomasz Wróbel, Anna Wolska‐Washer, Jerzy Zdzisław Błoński, Tadeusz Robak, Krzysztof Giannopoulos   +15 more
wiley   +1 more source

Friend or foe: divergent immunomodulatory effects of metabolites derived from the virucidal zinc finger inhibitor SAMT-247. [PDF]

Front Immunol
Woode EK, Goldfarbmuren KC, Arisa OT, Bissa M, Schifanella L, Robello M, Gunawardana M, Moss JA, Castonguay AE, Butkyavichene I, Jenkins LM, Ettienne EB, Appella DH, Baum MM, Figg WD, Franchini G, Rahman MA.   +16 more
europepmc   +1 more source

Fail-Closed Validation of Lineage-Associated Transcript-Count Diversity After IFN-β Stimulation in a Public Human PBMC Dataset. [PDF]

Int J Mol Sci
Quiroz RN, Lindo KE, Pinilla AJ, Díaz-Olmos Y, Fernández-Ponce C, Peñata EZ, Bello Lemus Y, Lugo LP, Londoño LP, Acosta Hoyos A, Freyle NG, Chamorro KER, Villarreal-Camacho JL, Navarro Quiroz E.   +13 more
europepmc   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Integrative population genomics and tissue-specific expression profiling in cattle using whole-genome sequence resources. [PDF]

BMC Genomics
Saeed-Zidane M, Blaj I, Yousif A, Thaller G.   +3 more
europepmc   +1 more source