Results 121 to 130 of about 98,093 (297)

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Senescent CD14+CD16+ Monocytes Exhibit Proinflammatory and Proatherosclerotic Activity

, 2011
In elderly subjects and in patients with chronic inflammatory diseases, there is an increased subset of monocytes with a CD14+CD16+ phenotype, whose origin and functional relevance has not been well characterized.
Paula Buendia, Rafael Ramirez, Pedro Aljama, Alejandro Martin-Malo, Julia Carracedo, Ana Merino   +5 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Surface expression of CD16 in NK cell clones.

, 2018
(A) Expression levels of CD16 in clones derived from different NK cell subsets analyzed at week 5 of cultivation. Proportions of CD16+ cells and MFI of CD16+ cells (mean ± SE) of n experiments are presented: n = 12 for CD56brightHLA-DR–, n = 10 for ...
William G. Telford (253706), Sofya A. Erokhina (6054128), Dean A. Lee (187483), Leonid M. Kanevskiy (6054131), Elena I. Kovalenko (6054134), Maria A. Streltsova (6054125), Alexander M. Sapozhnikov (377436)   +6 more
core   +1 more source

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

CD14 ^dim CD16 ⁺ and CD14 ⁺ CD16 ⁺ Monocytes in Obesity and During Weight Loss

, 2011
Objective— Studies suggest the implication of CD16 + subpopulations (CD14 + CD16 + , CD14 dim CD16
Nicolas Veyrie, Vanessa Benhamo, Mariana Renovato, Froogh Hajduch, Karine Clément, Isabelle Cremer, Wolf-Hervé Fridman, Catherine Sautès-Fridman, Meriem Abdennour, Elise Dalmas, Christine Poitou, Jean-François Kahn, Salwa Rizkalla   +12 more
core   +1 more source

Phenotypic, proteomic, and functional analyses of cytokine-induced memory-like NK cells show two distinct subsets based on CD16 expression

Scientific Reports
NK cells are innate lymphoid cells that can acquire a memory-like phenotype in vitro when stimulated with IL-12, IL-15, and IL-18. These cytokine-induced memory-like (CIML) NK cells exhibit prolonged lifespan and increased cytotoxicity, making them ideal
Sofía Carreira-Santos, Marina González-Sánchez, Nelson López-Sejas, Fakhri Hassouneh, Lauro González-Fernández, Inmaculada Jorge, Esther Durán, Alejandra Pera, Jesús Vázquez, Rafael Solana, Raquel Tarazona, Javier G. Casado   +11 more
doaj   +1 more source

Characterization of Natural Killer Cells and Cytokines in Maternal Placenta and Fetus of Diabetic Mothers

Journal of Immunology Research, 2016
The present study characterized natural killer cells and cytokines in diabetic mothers, their placenta, and fetus. In the maternal blood from the hyperglycemic groups, the CD16+CD56− NK cells increased, whereas that of CD16+CD56+ decreased in gestational
Cristiane de Castro Pernet Hara, Eduardo Luzía França, Danny Laura Gomes Fagundes, Adriele Ataides de Queiroz, Marilza Vieira Cunha Rudge, Adenilda Cristina Honorio-França, Iracema de Mattos Paranhos Calderon   +6 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Analysis of NK cells in CD16 deficient animals

Prirodnoubilačke ili stanice NK (engl. natural killer cells, NK cells) važna su sastavnica urođenog imunološkog sustava zbog svoje sposobnosti brzog prepoznavanja i eliminacije tumorskih i virusom zaraženih stanica.
Lačić, Laura
core   +3 more sources