Results 221 to 230 of about 98,093 (297)

Autoimmune neutropenia in children: Test cells versus beads and a role for pro‐LL‐37 and absolute neutrophil count

British Journal of Haematology, EarlyView.
A comparison between bead‐based and cell‐based assays for autoantibody detection in childhood neutropenia revealed substantial discordance between platforms. Bead‐based methods should be complemented with cell‐based methods for optimal diagnostic sensitivity. Incorporating pro‐LL‐37 and ANC measurements into the clinical workup of childhood neutropenia
Paul Ratcliffe, Alexandra Haara Löfstedt, Mikael Sundin, Petter Höglund   +3 more
wiley   +1 more source

CD38+ NK cells: novel players in immunoregulation. [PDF]

Front Immunol
Chang X, Fang K.
europepmc   +1 more source

Indole‐3‐Propionic Acid Drives Dendritic H3K27 Acetylation to Enhance CD8+ T Cell Immunity in Hepatocellular Carcinoma

Cancer Science, EarlyView.
The gut microbiota metabolite indole ‐ 3 ‐ propionic acid（IPA) enhanced the inhibitory effect of SCB on tumor growth in HCC mice. IPA upregulated IL‐12A expression through facilitating acetylation of H3K27 in DCs. IPA elevated IL‐12A expression in DCs to promote CD8+ T cell anti‐tumor immunity and ultimately enhances the efficacy of SCB therapy against
Rui Zhao, Siqi Liu, Qian Zhang, Wenrui Wang, Lanlan Yang, Xue Shao, Shengnan Jia, Zhenjing Jin   +7 more
wiley   +1 more source

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques. [PDF]

Cell Rep Med
Silva de Castro I, Rahman MA, Bissa M, Goldfarbmuren KC, Schifanella L, Sarkis S, N'guessan KF, Ma ZM, Gutowska A, Stamos JD, Doster MN, Woode EK, Smith JC, Kozlowski PA, Williams LD, McKinnon KM, Tomaras GD, Shen X, Montefiori DC, Santra S, Paquin-Proulx D, Maldarelli F, Cardozo T, Franchini G.   +23 more
europepmc   +1 more source

Targeted Photo‐Induced Elimination of Tumor‐Associated Macrophages Suppresses Cancer Progression in a Murine Model

Cancer Science, EarlyView.
This study demonstrates the selective depletion of tumor‐associated macrophages (TAMs) by targeting CSF1R through near‐infrared photoimmunotherapy (NIR‐PIT). Using a combination of anti‐CSF1R Fab‐IR700 conjugates and localized light irradiation, we achieved tumor suppression and durable antitumor immunity without systemic toxicity.
Kohei Nakajima, Tomomi Uchiyama, Kazuki Funayama, Yuto Goto, Akari Mukaimine, Naoya Ieda, Mikako Ogawa   +6 more
wiley   +1 more source

Publisher Correction: Continual integration of single-cell multimodal data with MIRACLE. [PDF]

Nat Comput Sci
Zhou J, Wang J, Hu S, Kan T, Feng C, Qiang X, Dong G, Shi J, Liu R, Bo X, Ou-Yang L, Ying X, He Z.   +12 more
europepmc   +1 more source

Natural killer cells from patients relapsing on daratumumab therapy express an exhausted-associated phenotype. [PDF]

Clin Hematol Int
Fladeland Iversen K, Nederby L, Lund T, Andreasen Leth T, Plesner T.   +4 more
europepmc   +1 more source

scRNA‐Seq in Gastric Cancer Reveals Macrophage‐Derived C1q as a Diagnostic Marker

Cancer Science, EarlyView.
Single‐cell sequencing of GC analyzed the tumor microenvironment and discovered the C1QA+ TAMs subpopulation with immunosuppressive function. The role of C1q in the prognosis and diagnosis of GC was demonstrated through plasma and tumor tissue from the GC cohort.
Saisai Gong, Yupeng Zhao, Sheng Yang, Tong Liu, Chengyun Li, Yun Zhou, Geyu Liang   +6 more
wiley   +1 more source

Menopausal timing and senescent-immune coupling in age-related lobular involution of the human breast: a longitudinal cohort study. [PDF]

EBioMedicine
Lue JC, Stallings-Mann M, Hoskin T, McCauley BM, Vierkant RA, Pacheco-Spann L, Fischer JL, Gehling DL, Seymour LR, Baker DJ, Degnim AC, Winham SJ, Sherman ME, Radisky DC.   +13 more
europepmc   +1 more source