Dietary polyphenols contribute to the regulation of protein deposition and muscle health through multiple interconnected mechanisms. They promote protein synthesis and myogenic differentiation mainly by modulating the PI3K/AKT/mTOR signaling pathway and myogenic regulatory factors, while suppressing excessive protein degradation through regulation of ...
Chen Liu +6 more
wiley +1 more source
Macrophage polarization modulates neutrophil extracellular trap dynamics and reciprocal macrophage responses. [PDF]
Blum L +5 more
europepmc +1 more source
Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Michael R. Williamson +13 more
wiley +1 more source
Abstract Advanced mycosis fungoides (MF) and Sézary syndrome (SS) are the most aggressive forms of cutaneous T‐cell lymphoma and remain associated with a poor prognosis and heterogeneous therapeutic approaches. Recent advances, including targeted therapies and improved transplant strategies, have substantially expanded treatment options, highlighting ...
Francesco Onida +29 more
wiley +1 more source
Immune Microenvironmental Analysis of Intraductal Papillary Neoplasms of the Bile Duct in Occupational Cholangiocarcinoma: Associations with Tumor Size. [PDF]
Kinoshita M +14 more
europepmc +1 more source
ABSTRACT Articular cartilage (AC) repair remains a major clinical challenge due to its limited healing capacity and the inability of current treatment strategies to restore long‐term function. Biomaterial‐based strategies which support favorable immune responses and appropriate progenitor cell function have shown promise in enhancing cartilage ...
Sinead A. O'Rourke +6 more
wiley +1 more source
Heterogeneity and plasticity of tumor-associated macrophages in oral squamous cell carcinoma: implications for diagnosis and tumor microenvironment characterization. [PDF]
Olmos M +7 more
europepmc +1 more source
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen +3 more
wiley +1 more source
CD163+ perivascular macrophages in schizophrenia: a research framework for testing macrophage-related mechanisms. [PDF]
Klein HC +8 more
europepmc +1 more source
Histopathological analysis of CD163 and myeloperoxidase expression in neutrophil-rich dermatoses. [PDF]
Quintella DC, Milito CB, Cuzzi T.
europepmc +1 more source

