Results 1 to 10 of about 88,420 (193)

Overexpression of CD86 Enhances the Ability of THP-1 Macrophages to Defend Against Talaromyces marneffei

Immunity, Inflammation and Disease, 2022
Background Macrophages are the first line of defense against Talaromyces marneffei. CD86 is a surface molecule expressed on antigen‐presenting cells, such as macrophages, that provide costimulatory signals necessary for T cell activation and survival. In
Donghua Liu, Rifeng Chen, Jinling Fang
exaly   +2 more sources

The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer

Frontiers in Immunology, 2021
Tumor-associated macrophages (TAMs) are pivotal for tumor progression and metastasis. We investigated the stromal CD86+TAM/CD163+TAM (CD86/CD163) ratio as a novel prognostic biomarker for stage II-III colorectal cancer (CRC).
Yuzhen Mo, Guozeng Xu
exaly   +3 more sources

CD86 in Dendritic Cell-Mediated Cancer Immunity: From Maturation Marker to Functional Regulator [PDF]

Biomedicines
Dendritic cell (DC)-based cancer immunotherapy remains limited by heterogeneous immune responses and variable clinical efficacy. CD86, a key co-stimulatory molecule, is traditionally regarded as a marker of dendritic cell maturation; however ...
Ting-Wei Wu, Chu-Hsin Chuang, Yi-Hui Wu
doaj   +2 more sources

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4

Frontiers in Immunology, 2020
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved.
Lucy Walker, David M Sansom, Neil Halliday   +2 more
exaly   +3 more sources

Longitudinal Change in CD86 Expression Is Associated with Regression of Cervical Intraepithelial Neoplasia [PDF]

Biomedicines
Background/Objectives: Cervical intraepithelial neoplasia (CIN) exhibits heterogeneous clinical behavior, with some lesions regressing spontaneously, whereas others persist or progress to higher-grade disease.
Rina Kawatake, Saki Kamata, Risa Yoshida, Rie Maruyama, Naoko Tomita, Yuki Katoh, Hanano Ando-Kobayashi, Nobuki Hayashi, Yuki Okuma, Osamu Kobayashi, Shinichiro Yabe, Keisuke Saito, Yoko Nakanishi, Shinobu Masuda, Kei Kawana   +14 more
doaj   +2 more sources

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source

Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin

OncoImmunology, 2021
Gliomas are heavily infiltrated with immune cells of myeloid origin. Past studies have shown that high-grade gliomas have a higher proportion of alternatively activated and suppressive myeloid cells when compared to low-grade gliomas, which correlate ...
Jayashree V. Raghavan, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Priyanka Arunachalam, Darshat Shah, Hari P. S., Akhila Lakshmikantha, Shibu Pillai, Komal Prasad Chandrachari, Kiran Mariswamappa, Sathyanarayana Lale, Nameeta Shah, Siddharth Jhunjhunwala   +14 more
doaj   +1 more source

Integrated Analysis Reveals Prognostic Value and Immune Correlates of CD86 Expression in Lower Grade Glioma

Frontiers in Oncology, 2021
BackgroundCD86 has great potential to be a new target of immunotherapy by regulating cancer immune response. However, it remains unclear whether CD86 is a friend or foe in lower-grade glioma (LGG).MethodsThe prognostic value of CD86 expression in pan ...
Huaide Qiu, Huaide Qiu, Wei Tian, Yikang He, Yikang He, Jiahui Li, Chuan He, Yongqiang Li, Ning Liu, Jianan Li   +9 more
doaj   +1 more source

CD86+/CD206+ tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma [PDF]

PeerJ, 2020
Background As the main cellular ingredients of tumor microenvironment, tumor-associated macrophages (TAMs) play a vital role in tumor development and progression.
Dalong Sun, Tiancheng Luo, Pingping Dong, Ningping Zhang, Jing Chen, Shuncai Zhang, Longzi Liu, Ling Dong, Si Zhang   +8 more
doaj   +2 more sources

Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients [PDF]

Türk Patoloji Dergisi
Objective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are ...
Esra COBANKENT AYTEKIN, Betul UNAL, Cumhur Ibrahim BASSORGUN, Ozlenen OZKAN   +3 more
doaj   +1 more source