Results 1 to 10 of about 72,124 (260)

CD86 regulates myeloma cell survival [PDF]

Blood Advances, 2017
: Although prognosis for patients with multiple myeloma has improved over the past decade, research toward discovery of new therapeutic avenues is important and could lead to a cure for this plasma cell malignancy.
Catherine M. Gavile, Benjamin G. Barwick, Scott Newman, Paola Neri, Ajay K. Nooka, Sagar Lonial, Kelvin P. Lee, Lawrence H. Boise   +7 more
doaj   +3 more sources

Overexpression of CD86 enhances the ability of THP‐1 macrophages to defend against Talaromyces marneffei

Immunity, Inflammation and Disease, 2022
Background Macrophages are the first line of defense against Talaromyces marneffei. CD86 is a surface molecule expressed on antigen‐presenting cells, such as macrophages, that provide costimulatory signals necessary for T cell activation and survival. In
Donghua Liu, Rifeng Chen
exaly   +2 more sources

The Ratio of CD86+/CD163+ Macrophages Predicts Postoperative Recurrence in Stage II-III Colorectal Cancer

Frontiers in Immunology, 2021
Tumor-associated macrophages (TAMs) are pivotal for tumor progression and metastasis. We investigated the stromal CD86+TAM/CD163+TAM (CD86/CD163) ratio as a novel prognostic biomarker for stage II-III colorectal cancer (CRC).
Yuzhen Mo
exaly   +3 more sources

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4

Frontiers in Immunology, 2020
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved.
Lucy Walker, David Sansom, Neil Halliday   +2 more
exaly   +3 more sources

CD86 is linked to apoptosis in canine histiocytic sarcoma

Frontiers in Veterinary Science
Immune checkpoints are critical for the regulation of tumor growth and regression. Recently an effect of CD80 and CD86 on tumor regression in canine cutaneous histiocytoma has been described.
Benjamin Diehl, Andreas Kirchhoff, Florian Hansmann   +2 more
doaj   +3 more sources

Extracellular vesicles as key biomarkers in COVID-19: insights into disease severity and mortality through CD86 and other immune markers [PDF]

Frontiers in Immunology
This study explores the concentration, size, and epitope profiles of extracellular vesicles (EVs) as biomarkers for COVID-19 outcomes. CD86 stood out as a key predictor of mortality, suggesting that EV profiling could help assess disease severity and ...
Lou Soret, Lou Soret, Coralie L. Guerin, Coralie L. Guerin, Joseph Roux de Bezieux, Katharine Rus, Léa Guyonnet, Georges Abi Abdallah, Georges Abi Abdallah, Nicolas Gendron, Nicolas Gendron, Anne Godier, Anne Godier, Diane Zlotnik, Diane Zlotnik, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Annick Viguier, Jean-Luc Diehl, Jean-Luc Diehl, Pascale Gaussem, Pascale Gaussem, Aurélien Philippe, Aurélien Philippe, David M. Smadja, David M. Smadja   +26 more
doaj   +2 more sources

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source

Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes [PDF]

The Journal of Immunology, 2013
Abstract CD86 engagement on a CD40L/IL-4–primed murine B cell activates signaling intermediates that promote NF-κB activation to increase Oct-2 and mature IgG1 mRNA and protein expression, as well as the rate of IgG1 transcription, without affecting class switch recombination.
Christopher R, Lucas, Hector M, Cordero-Nieves, Robert S, Erbe, Jaclyn W, McAlees, Sumeena, Bhatia, Richard J, Hodes, Kerry S, Campbell, Virginia M, Sanders   +7 more
openaire   +3 more sources

Immuno-phenotyping of IDH-mutant grade 3 astrocytoma and IDH-wildtype glioblastoma reveals specific differences in cells of myeloid origin

OncoImmunology, 2021
Gliomas are heavily infiltrated with immune cells of myeloid origin. Past studies have shown that high-grade gliomas have a higher proportion of alternatively activated and suppressive myeloid cells when compared to low-grade gliomas, which correlate ...
Jayashree V. Raghavan, Raksha A. Ganesh, Pranali Sonpatki, Divya Naik, Arivusudar Everad John, Priyanka Arunachalam, Darshat Shah, Hari P. S., Akhila Lakshmikantha, Shibu Pillai, Komal Prasad Chandrachari, Kiran Mariswamappa, Sathyanarayana Lale, Nameeta Shah, Siddharth Jhunjhunwala   +14 more
doaj   +1 more source

Integrated Analysis Reveals Prognostic Value and Immune Correlates of CD86 Expression in Lower Grade Glioma

Frontiers in Oncology, 2021
BackgroundCD86 has great potential to be a new target of immunotherapy by regulating cancer immune response. However, it remains unclear whether CD86 is a friend or foe in lower-grade glioma (LGG).MethodsThe prognostic value of CD86 expression in pan ...
Huaide Qiu, Huaide Qiu, Wei Tian, Yikang He, Yikang He, Jiahui Li, Chuan He, Yongqiang Li, Ning Liu, Jianan Li   +9 more
doaj   +1 more source