Results 11 to 20 of about 88,420 (193)
CD86 regulates myeloma cell survival [PDF]
Blood Advances, 2017 : Although prognosis for patients with multiple myeloma has improved over the past decade, research toward discovery of new therapeutic avenues is important and could lead to a cure for this plasma cell malignancy.
Catherine M. Gavile +7 more
doaj +4 more sources
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation [PDF]
Nature Immunology, 2022 Abstract CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80 and CD86, the specific requirement for two distinct ligands remains obscure.
Alan Kennedy +20 more
core +5 more sources
Canadian Respiratory Journal, 2022 Objective. The aim of the study was to explore the relevance of CD40, CD86, and GSTO1 with the pathogenesis of COPD. Methods. Patients with acute exacerbation of COPD were contrasted with the healthy and nonsmoking ones and smoking but without COPD ones.
Desheng Sun, Rong Lin, Yao Ouyang
doaj +2 more sources
Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma [PDF]
BMC Cancer, 2007 Background B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of ...
Lin Hsuan-Yu +4 more
doaj +3 more sources
CD86 is linked to apoptosis in canine histiocytic sarcoma
Frontiers in Veterinary ScienceImmune checkpoints are critical for the regulation of tumor growth and regression. Recently an effect of CD80 and CD86 on tumor regression in canine cutaneous histiocytoma has been described.
Benjamin Diehl +2 more
doaj +3 more sources
Clinical Immunology and Immunopathology, 1997 We screened peripheral blood mononuclear cells from 13 SLE patients, all having quiescent disease at the time of analysis, 12 allergy patients, and 21 normal subjects for the expression of CD80 (B7-1) and CD86 (B7-2, B70) on small (resting) and large (activated) subsets of CD19+ B cells.
D, Folzenlogen +4 more
openaire +3 more sources
What's the difference between CD80 and CD86?
Trends in Immunology, 2003 CD28 and CD152 have crucial yet opposing functions in T-cell stimulation, in which CD28 promotes but CD152 inhibits T-cell responses. Intriguingly, they share two ligands, CD80 and CD86, but at present there is no clear model for understanding whether a ligand will promote or inhibit responses. Current perceptions are based around the concept that CD86
David M, Sansom +2 more
openaire +3 more sources
Prohibitins and the Cytoplasmic Domain of CD86 Cooperate To Mediate CD86 Signaling in B Lymphocytes [PDF]
The Journal of Immunology, 2013 Abstract CD86 engagement on a CD40L/IL-4–primed murine B cell activates signaling intermediates that promote NF-κB activation to increase Oct-2 and mature IgG1 mRNA and protein expression, as well as the rate of IgG1 transcription, without affecting class switch recombination.
Christopher R, Lucas +7 more
openaire +3 more sources
Epigenetics, 2020 CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos +9 more
doaj +1 more source
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis
Frontiers in Immunology, 2021 CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this ...
Blagoje Soskic +10 more
doaj +1 more source