Results 11 to 20 of about 85,807 (290)
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation [PDF]
Nature Immunology, 2022 Abstract CD28 and CTLA-4 (CD152) play essential roles in regulating T cell immunity, balancing the activation and inhibition of T cell responses, respectively. Although both receptors share the same ligands, CD80 and CD86, the specific requirement for two distinct ligands remains obscure.
Alan Kennedy +20 more
core +5 more sources
Soluble CD86 Is a Costimulatory Molecule for Human T Lymphocytes [PDF]
Immunity, 2000 CD86 is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Here, we show that soluble CD86 is detected in human serum. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain ...
Jeannin, Pascale +11 more
openaire +5 more sources
Immunity, Inflammation and Disease, 2022 Background Macrophages are the first line of defense against Talaromyces marneffei. CD86 is a surface molecule expressed on antigen‐presenting cells, such as macrophages, that provide costimulatory signals necessary for T cell activation and survival. In
Rifeng Chen +5 more
doaj +1 more source
Clinicopathologic Evaluation of CD80, CD86, and PD-L1 Expressions with Immunohistochemical Methods in Malignant Melanoma Patients [PDF]
Türk Patoloji DergisiObjective: Diagnostic and prognostic biomarkers for malignant melanoma are crucial for treatment and for developing targeted therapies. Malignant melanoma is a highly immunogenic tumor, and its regression, treatment, and prognostic evaluation are ...
Esra COBANKENT AYTEKIN +3 more
doaj +1 more source
Epigenetics, 2020 CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos +9 more
doaj +1 more source
Canadian Respiratory Journal, 2022 Objective. The aim of the study was to explore the relevance of CD40, CD86, and GSTO1 with the pathogenesis of COPD. Methods. Patients with acute exacerbation of COPD were contrasted with the healthy and nonsmoking ones and smoking but without COPD ones.
Desheng Sun, Rong Lin, Yao Ouyang
doaj +1 more source
Exposure to the antimicrobial peptide LL-37 produces dendritic cells optimized for immunotherapy
OncoImmunology, 2019 Immunization of patients with autologous, ex vivo matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research.
Emily Gwyer Findlay +13 more
doaj +1 more source
برهمکنش های مولکولی بین CTLA-4 و CD80/CD86 در تنظیم پاسخ های ایمنی: مقاله مروری [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.یکی از اصلی ترین مکانیسم های تنظیم پاسخ های ایمنی برهم کنش متقابل CTLA-4 و CD80/CD86 است. CTLA-4 نوعی رسپتور مهاری و دارای لیگاندهای CD80/CD86 و مشترک با گیرنده کمک محرک CD28 است. CTLA-4 طی فرآیندی به نام ترانس اندوسیتوزیس این لیگاندها را اندوسیتوز کرده
زهرا درویش خلیل آبادی +2 more
doaj +1 more source
CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis
Frontiers in Immunology, 2021 CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this ...
Blagoje Soskic +10 more
doaj +1 more source
Functional CD86 (B7-2/B70) on Cultured Human Langerhans Cells [PDF]
, 1996 CD86 (B70/B7-2) has recently been identified as an alternative CD28/CTLA-4 ligand on activated B cells. CD86 has also been demonstrated as possibly serving as a primary costimulatory molecule in the initial immune response.
Satoh, Takahiro +8 more
core +1 more source