Results 21 to 30 of about 85,807 (290)

TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy

OncoImmunology, 2018
Cancer-induced myeloid-derived suppressor cells (MDSC) play an important role in tumor immune evasion. MDSC programming or polarization has been proposed as a strategy for leveraging the developmental plasticity of myeloid cells to reverse MDSC immune ...
Padmini Jayaraman, Falguni Parikh, Jared M. Newton, Aurelie Hanoteau, Charlotte Rivas, Rosemarie Krupar, Kimal Rajapakshe, Ravi Pathak, Kavin Kanthaswamy, Cassie MacLaren, Shixia Huang, Cristian Coarfa, Chad Spanos, Dean P. Edwards, Robin Parihar, Andrew G. Sikora   +15 more
doaj   +1 more source

Expression and Prognostic Value of CD80 and CD86 in the Tumor Microenvironment of Newly Diagnosed Glioblastoma. [PDF]

, 2022
BACKGROUND: Strategies to modulate the tumor microenvironment (TME) have opened new therapeutic avenues with dramatic yet heterogeneous intertumoral efficacy in multiple cancers, including glioblastomas (GBMs).

core   +4 more sources

Talaromyces marneffei Can Capture CD86 Proteins of Macrophages in vitro

Infection and Drug Resistance, 2022
Jinling Fang,* Rifeng Chen,* Donghua Liu* Department of Dermatology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Fang J, Chen R, Liu D
doaj  

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Arthritis Research & Therapy, 2020
Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation.
Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu   +7 more
doaj   +1 more source

Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration

Arthritis Research & Therapy, 2021
Background Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation.
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid   +5 more
doaj   +1 more source

Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells

OncoImmunology, 2019
Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi ...
David A. Davis, Prabha Shrestha, Ashley I. Aisabor, Alexandra Stream, Veronica Galli, Cynthia A. Pise-Masison, Takanobu Tagawa, Joseph M. Ziegelbauer, Genoveffa Franchini, Robert Yarchoan   +9 more
doaj   +1 more source

Molecular cloning, expression and functional characterization of miniature swine CD86

, 2005
CD86 is one of the key molecules involved in the co-stimulation of T cells. The complete cDNA encoding CD86 molecule of miniature swine was cloned and analyzed.
Cho, B., Park, D., Hwang, W. S., Choi, I., Kim, J. Y., Kim, S. D., Chung, D. H., Ahn, C., Park, C. G., Lee, J. S.   +9 more
core   +2 more sources

The Effect of Talaromyces marneffei Infection on CD86 Expression in THP-1 Cells

Infection and Drug Resistance, 2021
Di Yang,1,* Lin-xia Shen,1,2,* Ri-feng Chen,1,* Yu Fu,1 Hong-yan Xu,1 Li-na Zhang,1 Dong-hua Liu1,3 1Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of
Yang D, Shen L, Chen R, Fu Y, Xu H, Zhang L, Liu D   +6 more
doaj  

CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4

Frontiers in Immunology, 2020
CD80 and CD86 are expressed on antigen presenting cells and are required to engage their shared receptor, CD28, for the costimulation of CD4 T cells. It is unclear why two stimulatory ligands with overlapping roles have evolved.
Neil Halliday, Neil Halliday, Cayman Williams, Alan Kennedy, Erin Waters, Anne M. Pesenacker, Blagoje Soskic, Claudia Hinze, Tie Zheng Hou, Behzad Rowshanravan, Daniel Janman, Lucy S. K. Walker, David M. Sansom   +12 more
doaj   +1 more source

TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity

Frontiers in Immunology, 2023
Monocyte exhaustion characterized by immune-suppressive features can develop during sepsis and contribute to adverse patient outcomes. However, molecular mechanisms responsible for the establishment of immune-suppressive monocytes with reduced expression
Jing Wang, Yajun Wu, RuiCi Lin, Yao Zhang, Liwu Li   +4 more
doaj   +1 more source