Results 21 to 30 of about 72,124 (260)

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Arthritis Research & Therapy, 2020
Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation.
Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu   +7 more
doaj   +1 more source

Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration

Arthritis Research & Therapy, 2021
Background Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation.
Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid   +5 more
doaj   +1 more source

Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells

OncoImmunology, 2019
Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi ...
David A. Davis, Prabha Shrestha, Ashley I. Aisabor, Alexandra Stream, Veronica Galli, Cynthia A. Pise-Masison, Takanobu Tagawa, Joseph M. Ziegelbauer, Genoveffa Franchini, Robert Yarchoan   +9 more
doaj   +1 more source

The Effect of Talaromyces marneffei Infection on CD86 Expression in THP-1 Cells

Infection and Drug Resistance, 2021
Di Yang,1,* Lin-xia Shen,1,2,* Ri-feng Chen,1,* Yu Fu,1 Hong-yan Xu,1 Li-na Zhang,1 Dong-hua Liu1,3 1Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of
Yang D, Shen L, Chen R, Fu Y, Xu H, Zhang L, Liu D   +6 more
doaj  

TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity

Frontiers in Immunology, 2023
Monocyte exhaustion characterized by immune-suppressive features can develop during sepsis and contribute to adverse patient outcomes. However, molecular mechanisms responsible for the establishment of immune-suppressive monocytes with reduced expression
Jing Wang, Yajun Wu, RuiCi Lin, Yao Zhang, Liwu Li   +4 more
doaj   +1 more source

A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression. [PDF]

PLoS ONE, 2016
AIM:The lack of potent innate immune responses during HCV infection might lead to a delay in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes/macrophages (CD68+ cells) are essential to establish effective anti ...
Elias A Said, Iman Al-Reesi, Marwa Al-Riyami, Khalid Al-Naamani, Shadia Al-Sinawi, Mohammed S Al-Balushi, Crystal Y Koh, Juma Z Al-Busaidi, Mohamed A Idris, Ali A Al-Jabri   +9 more
doaj   +1 more source

A combination of the activation marker CD86 and the immune checkpoint marker B and T lymphocyte attenuator (BTLA) indicates a putative permissive activation state of B cell subtypes in healthy blood donors independent of age and sex

BMC Immunology, 2020
Background The use of anti-B cell based therapies in immune-mediated diseases targeting general B cell markers or molecules important for B cell function has increased the clinical needs of monitoring B cell subpopulations.
Susanne Axelsson, Anders Magnuson, Anna Lange, Aseel Alshamari, Elisabeth Hultgren Hörnquist, Olof Hultgren   +5 more
doaj   +1 more source

Significance of infiltration of M1 tumor-associated macrophages in hepatocellular carcinoma [PDF]

Zhongguo aizheng zazhi
Background and purpose: Tumor-associated macrophages (TAM) as the main stromal cells in the tumor microenvironment play an important role in tumor progression.
Feng XIAO, Tonglin XU, Lin ZHU, Jingwen XIAO, Tianqi WU, Chunyan GU   +5 more
doaj   +2 more sources

Supplementary figure 1. CD68+CD86-/low M0-macrophage and CD68+CD86+ M1-macrophage phenotypes.

, 2022
Representative flow cytometry gating of live cells for the M0 macrophages (negative ctrl) in (A) as well as forward (FSC) and side scatter (SSC) intensity plots to gating Singlet in (B) and morphological analysis in (C). Evaluation of M0 (left) and M1 (right) cell phenotypes (D-G) was determined by flow cytometry as percentage for the expression of the
Gori, Manuele, Giannitelli, Sara Maria, Vadalà, Gianluca, Papalia, Rocco, Zollo, Loredana, Sanchez, Massimo, Trombetta, Marcella, Rainer, Alberto, Di Pino, Giovanni, Denaro, Vincenzo   +9 more
openaire   +2 more sources

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source