Results 41 to 50 of about 72,124 (260)

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. [PDF]

PLoS Pathogens, 2014
Influenza A virus (IAV) infection in the respiratory tract triggers robust innate and adaptive immune responses, resulting in both virus clearance and lung inflammation and injury.
Emily K Moser, Matthew M Hufford, Thomas J Braciale   +2 more
doaj   +1 more source

Expression of Functional Molecule on Plasmacytoid Dendritic Cells Is Associated With HBsAg Loss in HBeAg-Positive Patients During PEG-IFN α-2a Treatment

Frontiers in Immunology, 2022
ObjectiveThe ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic cells (pDCs) is ...
Weihua Cao, Weihua Cao, Si Xie, Lu Zhang, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ruyu Liu, Min Chang, Shuling Wu, Ge Shen, Jianping Dong, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +16 more
doaj   +1 more source

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Effect of Vitamin D on the Spleen of Adult Male Rats Fed on Diet with High Fat: A Histological and Immunohistochemical Study [PDF]

The Egyptian Journal of Histology, 2019
Background: High fat diet (HFD) is the cause of obesity prevalence which is a serious health problem. Vitamin D is considered a very important modulator in cellular inflammation and immune systems.Aim of the work: To demonstrate the histological changes ...
Heba Mohamed
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Evaluation of Some Immunological Markers in Pregnant Women Infected with Cytomegalovirus in Kirkuk, Iraq

Medical Journal of Babylon
Background: Both innate and adaptive immunological responses may be activated by cytomegalovirus (CMV) infection, leading to significant reactions later in the course of the illness. Innate immune components, which react fast and nonspecifically, combine
Zena Muayad Nooruldeen, Mohammed Yawoz Nooruldeen   +1 more
doaj   +1 more source

Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxic-ischemic brain injury

Frontiers in Cellular Neuroscience, 2016
Immune cells display a high degree of phenotypic plasticity, which may facilitate their participation in both the progression and resolution of injury-induced inflammation.
Nina Hellström Erkenstam, Peter L.P. Smith, Bobbi Fleiss, Syam Nair, Pernilla Svedin, Wei Wang, Martina Boström, Pierre Gressens, Henrik Hagberg, Kelly L Brown, Karin Sävman, Carina Mallard   +11 more
doaj   +1 more source

Characterization of rat CD80 and CD86 by molecular cloning and mAb [PDF]

International Immunology, 1997
The CD28/B7 pathway provides a critical co-stimulatory signal for T cell activation. In the present study, we cloned rat CD80 and CD86 cDNA from a HTLV-1-transformed rat T cell line, Lewis-S1, expressing a high level of CTLA-4-Ig binding proteins.
K, Maeda, T, Sato, M, Azuma, H, Yagita, K, Okumura   +4 more
openaire   +2 more sources

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source