Results 41 to 50 of about 85,807 (290)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma

BMC Cancer, 2007
Background B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of ...
Lin Hsuan-Yu, Hsu Nicholas C, Chang Julia H, Chang Cheng-Shyong, Chung Chih-Yuan   +4 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Effect of Vitamin D on the Spleen of Adult Male Rats Fed on Diet with High Fat: A Histological and Immunohistochemical Study [PDF]

The Egyptian Journal of Histology, 2019
Background: High fat diet (HFD) is the cause of obesity prevalence which is a serious health problem. Vitamin D is considered a very important modulator in cellular inflammation and immune systems.Aim of the work: To demonstrate the histological changes ...
Heba Mohamed
doaj   +1 more source

Time-Dependent Serial Changes of Antigen-Presenting Cell Subsets in the Ocular Surface Are Distinct between Corneal Sterile Inflammation and Allosensitization in a Murine Model

Cells, 2021
The kinetics of antigen-presenting cells (APCs) vary depending on their resident tissues and the manner of immunization. We investigated the long-term changes in mature APC and T-cell subsets over 4 weeks in the ocular surface in murine models of corneal
Kyoung-Woo Kim, Hyun-Ju Lee, Hyeon-Ji Kim, Mee-Kum Kim   +3 more
doaj   +1 more source

Supplementary figure 1. CD68+CD86-/low M0-macrophage and CD68+CD86+ M1-macrophage phenotypes.

, 2022
Representative flow cytometry gating of live cells for the M0 macrophages (negative ctrl) in (A) as well as forward (FSC) and side scatter (SSC) intensity plots to gating Singlet in (B) and morphological analysis in (C). Evaluation of M0 (left) and M1 (right) cell phenotypes (D-G) was determined by flow cytometry as percentage for the expression of the
Gori, Manuele, Giannitelli, Sara Maria, Vadalà, Gianluca, Papalia, Rocco, Zollo, Loredana, Sanchez, Massimo, Trombetta, Marcella, Rainer, Alberto, Di Pino, Giovanni, Denaro, Vincenzo   +9 more
openaire   +2 more sources

CD86 expression at the nasal mucosa.

, 2013
After intervention, the percentages of CD86+ Cytokeratin+ epithelial (A) and CD86+ CD252+ non-epithelial (B) cells are compared at baseline between control (C0) and treatment (T0) groups and then again 24 hours after nasal allergen challenge (C24, T24); (
Marta Westwood (485655), Justin McCarville (485656), Kamal Ivory (485653), Claudio Nicoletti (485658), Allan Clark (80457), Claire Brockwell (485657), Laurian Zuidmeer-Jongejan (207754), Prasanna Sankaran (485654), Andrew M. Wilson (29107), Jack R. Dainty (227005)   +9 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Nucleic acid encoding feline CD86

, 1999
The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86,
Choi, Insoo, Winslow, Barbara J., Collisson, Ellen W., Cochran, Mark D.   +3 more
core   +1 more source