Results 51 to 60 of about 85,807 (290)

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Expression of Functional Molecule on Plasmacytoid Dendritic Cells Is Associated With HBsAg Loss in HBeAg-Positive Patients During PEG-IFN α-2a Treatment

Frontiers in Immunology, 2022
ObjectiveThe ideal endpoint of antiviral therapy in chronic hepatitis B (CHB) patients is to clear hepatitis B surface antigen (HBsAg). This study aimed to evaluate whether the expression of functional molecules on plasmacytoid dendritic cells (pDCs) is ...
Weihua Cao, Weihua Cao, Si Xie, Lu Zhang, Xiaoyue Bi, Yanjie Lin, Liu Yang, Yao Lu, Ruyu Liu, Min Chang, Shuling Wu, Ge Shen, Jianping Dong, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +16 more
doaj   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

Feline CD86 polypeptides and nucleic acids

, 2010
The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, feline CD86 (B7-2) ligand, feline CD28 receptor, or feline CTLA-4 (CD152) receptor, as well as vectors comprising nucleic acid encoding feline CD80, feline CD86,
Winslow, Barbara J., Collisson, Ellen W., Cochran, Mark D., Choi, In-soo   +3 more
core   +1 more source

Late engagement of CD86 after influenza virus clearance promotes recovery in a FoxP3+ regulatory T cell dependent manner. [PDF]

PLoS Pathogens, 2014
Influenza A virus (IAV) infection in the respiratory tract triggers robust innate and adaptive immune responses, resulting in both virus clearance and lung inflammation and injury.
Emily K Moser, Matthew M Hufford, Thomas J Braciale   +2 more
doaj   +1 more source

CD68, CD80, CD86 and PD-L1 staining in liver biopsies.

, 2016
Biopsies from HBV-infected and control individuals were stained with mouse anti-human CD68 and rabbit anti-human CD80, CD86 or PD-L1 Abs. Representative photomicrographs showing (A) CD68 red staining indicating CD68+ cells and (B-D) CD80, CD86 or PD-L1 ...
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Evaluation of Some Immunological Markers in Pregnant Women Infected with Cytomegalovirus in Kirkuk, Iraq

Medical Journal of Babylon
Background: Both innate and adaptive immunological responses may be activated by cytomegalovirus (CMV) infection, leading to significant reactions later in the course of the illness. Innate immune components, which react fast and nonspecifically, combine
Zena Muayad Nooruldeen, Mohammed Yawoz Nooruldeen   +1 more
doaj   +1 more source

Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxic-ischemic brain injury

Frontiers in Cellular Neuroscience, 2016
Immune cells display a high degree of phenotypic plasticity, which may facilitate their participation in both the progression and resolution of injury-induced inflammation.
Nina Hellström Erkenstam, Peter L.P. Smith, Bobbi Fleiss, Syam Nair, Pernilla Svedin, Wei Wang, Martina Boström, Pierre Gressens, Henrik Hagberg, Kelly L Brown, Karin Sävman, Carina Mallard   +11 more
doaj   +1 more source

A subpopulation of KS-positive microglia was CD86-positive.

, 2013
The spinal cord sections of SOD1G93A mice at 12, 18 and 24 weeks were stained with KS (A, E, I), M1 marker CD86 (B, F, J), and microglia marker Iba1 (C, G). The merged images are shown in (D, H, K).
Tomohiro Ohgomori (426726), Yukihiro Matsuyama (426730), Hideyuki Takeuchi (217302), Kazuyoshi Kobayashi (426727), Kenji Uchimura (426731), Naoki Ishiguro (426733), Shiro Imagama (426734), Kenichi Hirano (426725), Kenji Kadomatsu (426735), Fumiaki Tanaka (7313), Akihiro Hirakawa (309166), Akio Suzumura (48930), Gen Sobue (133031), Takamitsu Natori (426729), Tomohiro Matsumoto (426728), Kazuma Sakamoto (426732)   +15 more
core   +1 more source