Results 61 to 70 of about 85,807 (290)

Clinical significance of costimulatory molecules CD80/CD86 expression in IgA nephropathy [PDF]

, 2004
Clinical significance of costimulatory molecules CD80/CD86 expression in IgA nephropathy.BackgroundIgA nephropathy (IgAN) is the most common form of human glomerulonephritis. Tubulointerstitial inflammation with infiltration of mononuclear cells plays an
Wu, Qiong, Sakai, Hideto, Endoh, Masayuki, Jinde, Kiichiro   +3 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Tumor-associated macrophage expression in colorectal adenomas and carcinomas: relationship to Helicobacter pylori infection

Frontiers in Oncology
ObjectiveThis study investigated the association between Helicobacter pylori (H. pylori) infection and the expression of CD163+ and CD86+ tumor-associated macrophages (TAMs) in colorectal adenoma (CRA) and colorectal cancer (CRC) tissues ...
Wenming Wang, Wenming Wang, Yueyong Zhu, Yunchao Zhu, Jin Wang   +4 more
doaj   +1 more source

Increased CD86 but Not CD80 and PD-L1 Expression on Liver CD68+ Cells during Chronic HBV Infection.

PLoS ONE, 2016
BackgroundThe failure to establish potent anti-HBV T cell responses suggests the absence of an effective innate immune activation. Kupffer cells and liver-infiltrating monocytes/macrophages have an essential role in establishing anti-HBV responses. These
Elias A Said, Iman Al-Reesi, Marwa Al-Riyami, Khalid Al-Naamani, Shadia Al-Sinawi, Mohammed S Al-Balushi, Crystal Y Koh, Juma Z Al-Busaidi, Mohamed A Idris, Ali A Al-Jabri   +9 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

The JAK2V617F transgene initiates disease in both CD86⁺ and CD86⁻ HSC subsets.

, 2014
One hundred CD86+ or CD86− CD150+ CD48− HSC from CD45.2 JAK2V617F transgenic mice were transplanted to lethally irradiated CD45.1 recipient mice. (A) This table summarizes recipients that survived for at least 18 weeks after transplantation.
Zhizhuang Joe Zhao (208692), Ryuji Iida (452407), Robert S. Welner (546543), Kay L. Medina (452409), José Alberola-lla (546544), Wanke Zhao (504887), Paul W. Kincade (241189)   +6 more
core   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Immunology Research, 2018
CD86 molecule is the ligand for both costimulatory (CD28) and coinhibitory (CTLA-4) molecules, and it regulates immune response after allogeneic hematopoietic stem cell transplantation (alloHSCT).
Lidia Karabon, Miroslaw Markiewicz, Karolina Chrobot, Monika Dzierzak-Mietla, Edyta Pawlak-Adamska, Anna Partyka, Anna Koclega, Slawomira Kyrcz-Krzemien, Irena Frydecka   +8 more
doaj   +1 more source

Expression of costimulatory molecules in the bovine corpus luteum

Reproductive Biology and Endocrinology, 2007
Background Bovine luteal parenchymal cells express class II major histocompatibility complex (MHC) molecules and stimulate class II MHC-dependent activation of T cells in vitro. The ability of a class II MHC-expressing cell type to elicit a response from
Pate Joy L, Davis John S, Cannon Matthew J   +2 more
doaj   +1 more source

Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells

, 2011
Dendritic cells (DCs) require costimulatory molecules such as CD86 to efficiently activate T cells for the induction of adaptive immunity. DCs maintain minimal levels of CD86 expression at rest, but upregulate levels upon LPS stimulation.
Satoshi Ishido, Günther Baravalle, Megan McSweeney, Hyesuk Park, Yohei Matsuki, Mari Ohmura-Hoshino, Jeoung-Sook Shin   +6 more
core   +1 more source