Results 81 to 90 of about 88,420 (193)

Expression of CD86 on Human Islet Endothelial Cells Facilitates T Cell Adhesion and Migration

, 2008
Pancreatic islet endothelial cells (ECs) form the barrier across which autoreactive T cells transmigrate during the development of islet inflammation in type I diabetes.
Lozanoska-Ochser, Biliana, Peakman, Mark; id_orcid, Alvarez, Raymond A., Klein, Nigel J., Huang, Guo C.   +4 more
core   +3 more sources

A high-calorie diet exacerbates lipopolysaccharide-induced pneumonia by promoting acetate-mediated macrophage polarization via the HDAC9/10–HIF-1α–glycolysis axis

Frontiers in Immunology
Lung macrophage polarization imbalance is an important cause of aggravated pulmonary inflammation. The gut microbiota metabolites short-chain fatty acids (SCFAs) are an important regulator of macrophage polarization. A high-calorie diet has been shown to
Qianqian Li, Qianqian Li, Hui Liu, Chen Bai, Lin Jiang, Chen Su, Xueying Qin, Tiegang Liu, Xiaohong Gu, Xiaohong Gu   +9 more
doaj   +1 more source

Monovalent antibody scFv fragments selected to modulate T-cell activation by inhibition of CD86-CD28 interaction.

, 2007
Beside the interaction of the antigen-presenting major histocompatibility complex with the T-cell receptor, a co-stimulatory signal is required for T-cell activation in an immune response.
Thiel MA, Plückthun A, Kolly R, Herrmann T   +3 more
core   +1 more source

Extracellular vesicles as key biomarkers in COVID-19: insights into disease severity and mortality through CD86 and other immune markers

Frontiers in Immunology
This study explores the concentration, size, and epitope profiles of extracellular vesicles (EVs) as biomarkers for COVID-19 outcomes. CD86 stood out as a key predictor of mortality, suggesting that EV profiling could help assess disease severity and ...
Lou Soret, Lou Soret, Coralie L. Guerin, Coralie L. Guerin, Joseph Roux de Bezieux, Katharine Rus, Léa Guyonnet, Georges Abi Abdallah, Georges Abi Abdallah, Nicolas Gendron, Nicolas Gendron, Anne Godier, Anne Godier, Diane Zlotnik, Diane Zlotnik, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Annick Viguier, Jean-Luc Diehl, Jean-Luc Diehl, Pascale Gaussem, Pascale Gaussem, Aurélien Philippe, Aurélien Philippe, David M. Smadja, David M. Smadja   +26 more
doaj   +1 more source

CD86 costimulation enhances the antitumor activity of NKG2D CAR-Macrophages and synergizes with Anti-PD-L1 therapy to suppress prostate cancer progression

Cell Communication and Signaling
Prostate cancer remains one of the most prevalent solid tumors in men worldwide and poses a major therapeutic challenge due to its immunologically “cold” tumor microenvironment (TME), which is characterized by low T cell infiltration, limited antigen ...
Abdulrahman Ibrahim, Zihao Liang, Wan Liu, Xiaofei Di, Lawan Rabiu, Rong Li, Pengchao Zhang, Muhammad Auwal Saliu, Maoxuan Liu, Guizhong Zhang, Xiaochun Wan, Dehong Yan   +11 more
doaj   +1 more source

Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients

Brazilian Journal of Medical and Biological Research, 2007
Costimulatory and antigen-presenting molecules are essential to the initiation of T cell immunity to mycobacteria. The present study analyzed by immunocytochemistry, using monoclonal antibodies and alkaline phosphatase-anti-alkaline phosphatase method ...
V.C.S. Flores-Batista, N. Boechat, P.M. Lago, L.C. Lazzarini, L.R. Pessanha, A.S. Almeida, T.T. Mafort, A.L. Kritski, J.L. Ho, J.R. Lapa-e-Silva   +9 more
doaj  

CD86 Gene [PDF]

, 2020
openaire   +1 more source

In vitro anti-tumour activity of anti-CD80 and anti-CD86 immunotoxins containing type 1 ribosome-inactivating proteins

, 2000
Immunotoxins specific for the CD80 and CD86 antigens were prepared by linking three type 1 ribosome-inactivating proteins (RIPs), namely bouganin, gelonin and saporin-S6, to the monoclonal antibodies M24 (anti-CD80) and 1G10 (anti-CD86).
Polito L., Lubelli C., Boon L., Lemoli R. M., De Boer M., Tazzari P. L., Bolognesi A., Fogli M., Stirpe F.   +8 more
core   +1 more source

HBV infection is associated with elevated CD68⁺CD86⁺ cell count and percentage in the lobular areas of the liver.

, 2016
Biopsies from control and HBV-infected individuals were stained with mouse anti-human CD68 and rabbit anti-human CD86 Abs. CD68+CD86+ cell count in (A) the lobular area and (B) the total (lobular and portal) areas of the liver of control and HBV-infected
Crystal Y. Koh (2605771), Khalid Al-Naamani (2605789), Mohammed S. Al-Balushi (2605783), Mohamed A. Idris (2605777), Shadia Al-Sinawi (2605765), Ali A. Al-Jabri (2605780), Juma Z. Al-Busaidi (2605762), Marwa Al-Riyami (2605774), Elias A. Said (2605768), Iman Al-Reesi (2605786)   +9 more
core   +1 more source

CD86 Positive [PDF]

, 2020
openaire   +1 more source