Results 1 to 10 of about 90,181 (262)

The CD28 Transmembrane Domain Contains an Essential Dimerization Motif

Frontiers in Immunology, 2020
CD28 plays a critical role in regulating immune responses both by enhancing effector T cell activation and differentiation and controlling the development and function of regulatory T cells.
Scott A. Leddon, Margaret M. Fettis, Kristin Abramo, Ryan Kelly, David Oleksyn, Jim Miller   +5 more
doaj   +1 more source

The effect of sodium deoxyribonucleate with iron complex on the expression of surface markers of MT-4 cells infected with human immunodeficiency virus type 1 (HIV-1) (Retroviridae: Primate lentivirus group)

Вопросы вирусологии
Introduction. The persistence of immune dysfunction during therapy has serious consequences for the health of HIV-infected people. Therefore, an important direction is the search for drugs that can reduce the inflammatory potential of the immune system ...
Dmitry N. Nosik, Lyudmila B. Kalnina, Lyudmila M. Selimova, Ellie N. Kaplina   +3 more
doaj   +1 more source

Serum exosomes as predictors of clinical response to ipilimumab in metastatic melanoma

OncoImmunology, 2018
Immunotherapy is effective in metastatic melanoma (MM) but most studies failed in discovering a biomarker predictive of clinical response. Exosomes (Exo) from melanoma cells are detectable in sera of MM patients similarly to those produced by immune ...
Marco Tucci, Anna Passarelli, Francesco Mannavola, Luigia Stefania Stucci, Paolo Antonio Ascierto, Marilena Capone, Gabriele Madonna, Patrizia Lopalco, Francesco Silvestris   +8 more
doaj   +1 more source

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

OncoImmunology, 2019
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers   +5 more
doaj   +1 more source

THE ROLE OF PREGNANCY-SPECIFIC GLYCOPROTEIN IN REGULATION OF MOLECULAR GENETIC DIFFERENTIATION MECHANISMS OF IMMUNE MEMORY T CELLS

Медицинская иммунология, 2019
The role of pregnancy-specific β1-glycoprotein (PSG) in the regulation of molecular genetic factors determining the functional activity of naїve T cells and T cells of immune memory in vitro was studied.
M. B. Rayev, L. S. Litvinova, K. A. Yurova, O. G. Khaziakhmatova, V. P. Timganova, M. S. Bochkova, P. V. Khramtsov, S. A. Zamorina   +7 more
doaj   +1 more source

Human CD8+CD28− T suppressor cells expanded by common gamma chain (γc) cytokines retain steady allospecific suppressive capacity in vivo

BMC Immunology, 2020
Background CD8+CD28− T suppressor (Ts) cells play critical role in transplant tolerance. Our previous study has generated CD8+CD28− Ts cells in vitro which exert robust allospecific suppressive capacity in vitro.
Guihuan Liu, Yuming Yu, Fu Feng, Ping Zhu, Hua Zhang, Danni Zhang, Xiaoqiang Feng, Zedan Zhang, Yanjun Liu   +8 more
doaj   +1 more source

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Frontiers in Immunology, 2018
Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T
Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Bernard Vanhove, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf   +9 more
doaj   +1 more source

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

Molecular Therapy: Oncolytics, 2020
B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs).
Phuong Nguyen, Emmanuel Okeke, Michael Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra Pruett-Miller, James Papizan, Jennifer Moore, Sheng Zhou, Robert Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo   +13 more
doaj   +1 more source

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. [PDF]

PLoS ONE, 2011
CD28 costimulation is a critical event in the full activation of CD4(+) T cells that augments cytokine gene transcription, promotes cytokine mRNA stability, prevents induction of anergy, increases cellular metabolism, and increases cell survival. However,
Sujit V Janardhan, Kesavannair Praveen, Reinhard Marks, Thomas F Gajewski   +3 more
doaj   +1 more source

The Expression of CD28 and Its Synergism on the Immune Response of Flounder (Paralichthys olivaceus) to Thymus-Dependent Antigen

Frontiers in Immunology, 2021
CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing, Jing Xing, Wenjing Liu, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source