Results 1 to 10 of about 107,086 (298)

CD28 costimulation regulates genome-wide effects on alternative splicing. [PDF]

PLoS ONE, 2012
CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone.
Manish J Butte, Sun Jung Lee, Jonathan Jesneck, Mary E Keir, W Nicholas Haining, Arlene H Sharpe   +5 more
doaj   +3 more sources

Assessment of the Role of CTLA-4 and CD28 in a Sample of Iraqi Patients with Psoriasis in the Presence of Staphylococcus aureus Colonization

Medical Journal of Babylon
Background: There is substantial evidence that the dysregulation of immune cells in the skin, specifically T lymphocytes, plays a crucial role in the development of psoriasis.
Ali Nayyef Umayra, Jabbar S. Hassan, Hasan Nasir Mohsen   +2 more
doaj   +1 more source

T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.

PLoS ONE, 2014
T cell activation takes place in the context of a spatial and kinetic reorganization of cell surface proteins and signaling molecules at the contact site with an antigen presenting cell, termed the immunological synapse.
Mariano Sanchez-Lockhart, Ana V Rojas, Margaret M Fettis, Richard Bauserman, Trissha R Higa, Hongyu Miao, Richard E Waugh, Jim Miller   +7 more
doaj   +1 more source

Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. [PDF]

PLoS Biology, 2011
Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an ...
Gila Arad, Revital Levy, Iris Nasie, Dalia Hillman, Ziv Rotfogel, Uri Barash, Emmanuelle Supper, Tomer Shpilka, Adi Minis, Raymond Kaempfer   +9 more
doaj   +1 more source

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

eLife, 2014
The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation.
Michelle A Linterman, Alice E Denton, Devina P Divekar, Ilona Zvetkova, Leanne Kane, Cristina Ferreira, Marc Veldhoen, Simon Clare, Gordon Dougan, Marion Espéli, Kenneth GC Smith   +10 more
doaj   +1 more source

Loss of CD28 expression associates with severe T-cell exhaustion in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionDespite accumulated evidence in T-cell exhaustion in acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade in AML failed to achieve satisfying efficacy ...
Yueting Huang, Yueting Huang, Huijian Zheng, Huijian Zheng, Yuwen Zhu, Yuwen Zhu, Yan Hong, Yan Hong, Jie Zha, Jie Zha, Zhijuan Lin, Zhijuan Lin, Zhifeng Li, Zhifeng Li, Caiyan Wang, Caiyan Wang, Zhihong Fang, Zhihong Fang, Xingxing Yu, Xingxing Yu, Long Liu, Long Liu, Bing Xu, Bing Xu   +23 more
doaj   +1 more source

The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells

Retrovirology, 2018
Background The HIV-1 accessory proteins Nef and Vpu alter cell surface levels of multiple host proteins to modify the immune response and increase viral persistence.
Emily N. Pawlak, Brennan S. Dirk, Rajesh Abraham Jacob, Aaron L. Johnson, Jimmy D. Dikeakos   +4 more
doaj   +1 more source

An Enigmatic Tail of CD28 Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
CD28 costimulation regulates a wide range of cellular processes, from proliferation and survival to promoting the differentiation of specialized T-cell subsets. Since first being identified over 20 years ago, CD28 has remained a subject of intense study because of its profound consequences on T cell function and its potential for therapeutic ...
Jonathan S, Boomer, Jonathan M, Green
openaire   +2 more sources

The role of CD319, CD117, CD28, CD49e, CD56, and CD44 expression as diagnostic and prognostic markers in multiple myeloma

Iraqi Journal of Hematology
BACKGROUND: Multiple myeloma (MM) is a plasma cell disorder characterized by the infiltration of clonal plasma cells in the bone marrow and the detection of a monoclonal immunoglobulin in serum and/or urine.
May Ahmed Al-Ahmed, Haithem Ahmed Al-Rubaie   +1 more
doaj   +1 more source

Staphylococcal and Streptococcal Superantigens Trigger B7/CD28 Costimulatory Receptor Engagement to Hyperinduce Inflammatory Cytokines

Frontiers in Immunology, 2019
Staphylococcal and streptococcal superantigens are virulence factors that cause toxic shock by hyperinducing inflammatory cytokines. Effective T-cell activation requires interaction between the principal costimulatory receptor CD28 and its two coligands,
Andrey Popugailo, Ziv Rotfogel, Emmanuelle Supper, Dalia Hillman, Raymond Kaempfer   +4 more
doaj   +1 more source