Results 11 to 20 of about 107,086 (298)
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 [PDF]
Frontiers in Immunology, 2021 Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular ...
Qizhi Tang +2 more
exaly +10 more sources
Mitochondrial Priming by CD28 [PDF]
Cell, 2017 T cell receptor (TCR) signaling without CD28 can elicit primary effector T cells, but memory T cells generated during this process are anergic, failing to respond to secondary antigen exposure. We show that, upon T cell activation, CD28 transiently promotes expression of carnitine palmitoyltransferase 1a (Cpt1a), an enzyme that facilitates ...
Erika Pearce +2 more
exaly +7 more sources
SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling
eLife, 2022 T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of activated T cells.
Manuela Ecker +9 more
doaj +2 more sources
Association of CD28 IVS3 +17T/C Polymorphism with Soluble CD28 in Rheumatoid Arthritis [PDF]
Disease Markers, 2011 Objective:Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology in which inflammatory pathology involves T cell activation and the CD28 costimulatory molecule involved in T cell presentation. The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28
Ledezma-Lozano, I. Y. +9 more
openaire +3 more sources
CD28 Aptamers as Powerful Immune Response Modulators
Molecular Therapy: Nucleic Acids, 2013 CD28 is one of the main costimulatory receptors responsible for the proper activation of T lymphocytes. We have isolated two aptamers that bind to the CD28 receptor.
Fernando Pastor +10 more
doaj +2 more sources
CD28: Direct and Critical Receptor for Superantigen Toxins
Toxins, 2013 Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response ...
Ziv Rotfogel +5 more
doaj +2 more sources
CD3+CD8+CD28− T Lymphocytes in Patients with Lupus Nephritis [PDF]
Journal of Immunology Research, 2016 The results of studies on the CD3+CD8+CD28- cells in SLE are inconsistent since several analyses describe CD3+CD8+CD28- as either immunosuppressive or cytotoxic.
Marcelina Żabińska +3 more
doaj +2 more sources
CD28- cells are increased in early rheumatoid arthritis and are linked with cytomegalovirus status [PDF]
, 2020 Objective: CD3+CD8+CD28- cells are higher in Rheumatoid Arthritis (RA). The aim of this study was to assess CD3+CD8+CD28- cells in patients with early RA and assess the effects of cytomegalovirus (CMV) seropositivity.
Charlie Thompson (6815657) +4 more
core +2 more sources
OncoImmunology, 2022 CTLA4-CD28 gene fusion has been reported to occur in diverse types of T cell lymphoma. The fusion event is expected to convert inhibitory signals to activating signals and promote proliferation and potentially transformation of T cells.
Gyu Jin Lee +5 more
doaj +1 more source
Journal of Research in Medical Sciences, 2021 Several studies have demonstrated that the genetic polymorphisms in the genes encoding immune regulatory molecules, namely cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and CD28, play a fundamental role in susceptibility to rheumatoid arthritis (RA)
Mohammad Javad Mousavi +6 more
doaj +1 more source