Results 41 to 50 of about 107,086 (298)

CD28: a signalling perspective [PDF]

Biochemical Journal, 1996
CD28 and the related molecule cytotoxic T lymphocyte-associated molecule-4 (CTLA-4), together with their natural ligands B7.1 and B7.2, have been implicated in the differential regulation of several immune responses. CD28 provides signals during T cell activation which are required for the production of interleukin 2 and other cytokines and chemokines,
openaire   +2 more sources

Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells

OncoImmunology, 2019
Protective T cell responses against tumors require the production of Interferon gamma (IFN-γ). However, tumor-infiltrating T cells (TILs) gradually lose their capacity to produce IFN-γ and therefore fail to clear malignant cells.
Fiamma Salerno, Aurelie Guislain, Julian J. Freen-Van Heeren, Benoit P. Nicolet, Howard A. Young, Monika C. Wolkers   +5 more
doaj   +1 more source

THE ROLE OF PREGNANCY-SPECIFIC GLYCOPROTEIN IN REGULATION OF MOLECULAR GENETIC DIFFERENTIATION MECHANISMS OF IMMUNE MEMORY T CELLS

Медицинская иммунология, 2019
The role of pregnancy-specific β1-glycoprotein (PSG) in the regulation of molecular genetic factors determining the functional activity of naїve T cells and T cells of immune memory in vitro was studied.
M. B. Rayev, L. S. Litvinova, K. A. Yurova, O. G. Khaziakhmatova, V. P. Timganova, M. S. Bochkova, P. V. Khramtsov, S. A. Zamorina   +7 more
doaj   +1 more source

Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells. [PDF]

PLoS ONE, 2011
CD28 costimulation is a critical event in the full activation of CD4(+) T cells that augments cytokine gene transcription, promotes cytokine mRNA stability, prevents induction of anergy, increases cellular metabolism, and increases cell survival. However,
Sujit V Janardhan, Kesavannair Praveen, Reinhard Marks, Thomas F Gajewski   +3 more
doaj   +1 more source

Prevention of lupus nephritis development in NZB/NZW mice by selective blockade of CD28

, 2017
International audienceSystemic lupus erythematosus (SLE) is a chronic systemic inflammatory disease. Autoan-tibodies (autoAbs) against double-stranded DNA (ds DNA), the hallmark of lupus, are produced and maintained by the interaction between auto ...
Poirier, Nicolas, Moreau, A., Vanhove, B., Mary, C., Laurent, L., Fakhouri, F., Awena Le Fur, Fakhouri, Fadi, Anne Moreau, Le Fur, Awena, Bloas, R. L., Mary, Caroline, Laurent, Laetitia, Neel, M., Le Bloas, Rozenn, Laetitia Laurent, Poirier, N., Vanhove, Bernard, Fadi Fakhouri, Moreau, Anne, Néel, Mélanie, Rozenn Le Bloas, Le Fur, A., Nicolas Poirier, Bernard Vanhove, Mélanie Néel, Caroline Mary   +26 more
core   +1 more source

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Frontiers in Immunology, 2018
Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimulation for full activation. To revisit the role of CD28 costimulation in mouse T cell recall responses, we adoptively transferred in vitro generated OT-II T
Daniela Langenhorst, Stephanie Haack, Selina Göb, Anna Uri, Fred Lühder, Bernard Vanhove, Bernard Vanhove, Bernard Vanhove, Thomas Hünig, Niklas Beyersdorf   +9 more
doaj   +1 more source

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells

Molecular Therapy: Oncolytics, 2020
B7-H3 is actively being explored as an immunotherapy target for pediatric patients with solid tumors using monoclonal antibodies or T cells expressing chimeric antigen receptors (CARs).
Phuong Nguyen, Emmanuel Okeke, Michael Clay, Dalia Haydar, Julie Justice, Carla O’Reilly, Shondra Pruett-Miller, James Papizan, Jennifer Moore, Sheng Zhou, Robert Throm, Giedre Krenciute, Stephen Gottschalk, Christopher DeRenzo   +13 more
doaj   +1 more source

The Expression of CD28 and Its Synergism on the Immune Response of Flounder (Paralichthys olivaceus) to Thymus-Dependent Antigen

Frontiers in Immunology, 2021
CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing, Jing Xing, Wenjing Liu, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source