Results 1 to 10 of about 71,028 (295)

CD80 On Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis

Frontiers in Immunology, 2021
CD80 and CD86 are expressed on antigen presenting cells (APCs) and their role in providing costimulation to T cells is well established. However, it has been shown that these molecules can also be expressed by T cells, but the significance of this ...
David M Sansom, Neil Halliday, Behzad Rowshanravan   +2 more
exaly   +3 more sources

CD80 (B7-1) as a potential therapeutic target in Epstein–Barr virus‑associated B cell diseases [PDF]

Scientific Reports
Epstein-Barr virus (EBV)-associated B-cell lymphomas pose a therapeutic challenge due to their resistance to conventional chemotherapy and limited efficacy of current targeted approaches.
Rin Yoshizato, Mariko Miura, Yumi Tamura, Yohei Kawano, Yuya Hokama, Nanami Soda, Yusei Ota, Kotomi Yamashita, Taisei Fukushima, Masataka Ishimura, Shouichi Ohga, Tomoharu Yasuda   +11 more
doaj   +2 more sources

Expression of CD80 and HLA-DR molecules on blood monocytes in patients with pulmonary tuberculosis

Медицинская иммунология, 2021
We examined expression pattern of CD80 and HLA-DR pro-inflammatory molecules on the monocytes in patients with pulmonary tuberculosis (TB), depending on the clinical form of the disease and susceptibility of the pathogen to anti-tuberculosis drugs.
E. G. Churina, A. V. Popova, O. I. Urazova, M. R. Patysheva, S. P. Chumakova, Yu. V. Kolobovnikova, E. O. Kazakova   +6 more
doaj   +1 more source

Elevated urinary CD80 excretion in children with steroid-responsive nephrotic syndrome

Biomedical and Biotechnology Research Journal, 2022
Background: Idiopathic nephrotic syndrome (INS) is one of the most common glomerular diseases in children with different pathological types and different responses to corticosteroids.
Nakysa Hooman, Hasan Otukesh, Rozita Hosseini, Azar Nickavar, Farzaneh Dastan, Mahboubeh Jafari Sarouei, Parisa Honarpisheh   +6 more
doaj   +1 more source

Novel approaches to increase resistance to acute respiratory infections

RUDN Journal of Medicine, 2021
Relevance . Respiratory infections are the most common in the world. In order to prevent epidemics, there is a need to improve the strategies for organizing medical care and develop new approaches in order to increase the nonspecific resistance, mobilize
Svetlana V. Guryanova, Natalia A. Kudryashova, Anastasiya A. Kataeva, Bubusaira T. Orozbekova, Natalia V. Kolesnikova, Alexandr G. Chuchalin   +5 more
doaj   +1 more source

Expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis

Бюллетень сибирской медицины, 2021
The aim of this study was to identify features of the expression of pro-inflammatory and co-stimulatory molecules on the surface of macrophages in vitro in patients with pulmonary tuberculosis, depending on the clinical form of the disease and ...
E. G. Churina, A. V. Sitnikova, O. I. Urazova, V. V. Novitskiy, M. R. Patysheva, P. N. Golubchikov, E. P. Stepanova   +6 more
doaj   +1 more source

CD80 expression is upregulated by TP53 activation in human cancer epithelial cells

OncoImmunology, 2021
CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit cancer progression; however, the current understanding of the regulation of its expression on human tumor cells is limited. The TP53 tumor suppressor plays a
Melania Scarpa, Chiara Marchiori, Marco Scarpa, Ignazio Castagliuolo   +3 more
doaj   +1 more source

Characterization of Co-Stimulatory Ligand CD80/86 and Its Effect as a Molecular Adjuvant on DNA Vaccine Against Vibrio anguillarum in Flounder (Paralichthys olivaceus)

Frontiers in Immunology, 2022
The CD80/86 molecule is one of the important co-stimulatory ligands and involves antigen-specific immune responses by ligating with CD28 and then delivering the required second signal to T-cell activation. In this study, a CD80/86 homolog was identified,
Wenjing Liu, Jing Xing, Jing Xing, Xiaoqian Tang, Xiaoqian Tang, Xiuzhen Sheng, Heng Chi, Wenbin Zhan, Wenbin Zhan   +8 more
doaj   +1 more source

The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas

Epigenetics, 2020
CTLA-4 blocking therapeutic antibodies are currently under investigation in head and neck squamous cell carcinoma (HNSCC). A better understanding of the epigenetic regulation of the CD28 superfamily members CD28, CTLA-4, and ICOS and their B7 ligands ...
Luka de Vos, Ingela Grünwald, Emma Grace Bawden, Jörn Dietrich, Kathrin Scheckenbach, Constanze Wiek, Romina Zarbl, Friedrich Bootz, Jennifer Landsberg, Dimo Dietrich   +9 more
doaj   +1 more source

Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. [PDF]

PLoS ONE, 2014
CD80 plays a critical role in stimulation of T cells and subsequent control of infection. To investigate the effect of CD80 on HSV-1 infection, we constructed a recombinant HSV-1 virus that expresses two copies of the CD80 gene in place of the latency ...
Kevin R Mott, Sariah J Allen, Mandana Zandian, Omid Akbari, Pedram Hamrah, Hadi Maazi, Steven L Wechsler, Arlene H Sharpe, Gordon J Freeman, Homayon Ghiasi   +9 more
doaj   +1 more source