Results 1 to 10 of about 69,003 (290)

Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction

Cell Reports
Summary: The CTLA-4 and PD-1 checkpoints control immune responses and are key targets in immunotherapy. Both pathways are connected via a cis interaction between CD80 and PD-L1, the ligands for CTLA-4 and PD-1, respectively. This cis interaction prevents
Maximillian A. Robinson, Alan Kennedy, Carolina T. Orozco, Hung-Chang Chen, Erin Waters, Dalisay Giovacchini, Kay Yeung, Lily Filer, Claudia Hinze, Christopher Lloyd, Simon J. Dovedi, David M. Sansom   +11 more
doaj   +4 more sources

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia [PDF]

The Journal of Experimental Medicine, 1997
CD80 and CD86 (B7-1 and B7-2) are the ligands on antigen-presenting cells (APCs) which bind CD28 and deliver the costimulatory signals necessary for T cell activation. The reasons for the existence of two CD28 binding molecules are not well understood.
Harris, N., Peach, R., Naemura, J., Linsley, P. S., Le Gros, G., Ronchese, F.   +5 more
openaire   +5 more sources

Maximal ‘CD80-uria’ with minimal change [PDF]

Kidney International, 2010
Differentiation between minimal-change disease and focal segmental glomerulosclerosis remains challenging, particularly at early stages in children and adults. Garin et al. identify urinary CD80 excretion levels as a potential marker to differentiate the former entity from the latter. Thus, CD80 expression on podocytes, which was initially described in
Kistler, Andreas D., Reiser, Jochen
openaire   +4 more sources

CD80 Is Upregulated in a Mouse Model with Shear Stress-Induced Atherosclerosis and Allows for Evaluating CD80-Targeting PET Tracers [PDF]

Molecular Imaging and Biology, 2016
Molecular Imaging and Biology, 19 (1)
Meletta, Romana, Steier, Larissa, Borel, Nicole, Mu, Linjing, Keller, Claudia, Chiotellis, Aristeidis, Russo, Erica, Halin, Cornelia, Ametamey, Simon M, Schibli, Roger, Krämer, Stefanie D, Müller Herde, Adrienne   +11 more
openaire   +7 more sources

Immunolocalization of CD80 and CD86 in Non-Small Cell Lung Carcinoma: CD80 as a Potent Prognostic Factor

Acta Histochemica Et Cytochemica, 2022
It has been demonstrated that tumor cells express programed cell death protein 1 (PD-L1) to escape T lymphocytes that express programed cell protein 1 (PD-1), and PD-1/PD-L1 immune checkpoint inhibitors have been regarded in lung cancer patients. CD80 and CD86 are members of B7 superfamily which regulates T lymphocyte activation and tolerance. However,
Mitsunori Higuchi, Kiyoshi Takagi, Takashi Suzuki   +2 more
exaly   +4 more sources

Immunologic Significance of CD80/CD86 or Major Histocompatibility Complex-II Expression in Thymic Epithelial Tumors [PDF]

JTO Clinical and Research Reports, 2023
Introduction: Unresectable or recurrent thymic epithelial tumors (TETs) have a poor prognosis, and treatment options are limited. This study aimed to investigate the immunologic significance of CD80/CD86 or major histocompatibility complex class II (MHC ...
Hideki Ikeda, MD, Joji Nagasaki, MD, PhD, Daiki Shimizu, MD, Yuki Katsuya, MD, PhD, Hidehito Horinouchi, MD, PhD, Yukio Hosomi, MD, PhD, Etsuko Tanji, MS, Takekazu Iwata, MD, PhD, Makiko Itami, MD, PhD, Masahito Kawazu, MD, PhD, Yuichiro Ohe, MD, PhD, Takuji Suzuki, MD, PhD, Yosuke Togashi, MD, PhD   +12 more
doaj   +2 more sources

Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates

Developmental and Comparative Immunology, 2018
In mammals, the binding of distinct costimulatory ligands CD80 and CD86 to their receptors is essential for optimal T cell activation. Previous studies have shown that only a single CD80/86 gene exists in rainbow trout (termed rtCD80/86A) and other ...
Yong-An Zhang, Xu-Jie Zhang, Xiang-Yang Zhang   +2 more
exaly   +2 more sources

CD80/86 Inhibitors: Abatacept

, 2016
CD80/CD86 inhibitors are protein constructs which bind and inactivate CD80/CD86 on the surfaces of antigen-presenting B-cells and monocytes, blocking the costimulatory signal between these cells and CD28 on T-cells that is the second message of T-cell receptor/MHC interaction.
Pile, Kevin (R17082), Graham, Garry G., Mahler, Stephen M.   +2 more
openaire   +4 more sources

Differential Requirement for CD80 and CD80/CD86-Dependent Costimulation in the Lung Immune Response to an Influenza Virus Infection [PDF]

The Journal of Immunology, 2000
Abstract The CD28 costimulatory pathway is critical to T cell activation. Blockade of the interaction of CD28 with its ligands CD80 and CD86 using CTLA4-Ig has been proposed as a therapy for a number of immune-based disorders. We have used a murine model of influenza virus infection to study the role of CD28-dependent costimulation in
Lumsden, J. M., Roberts, J. M., Harris, N. L., Peach, R. J., Ronchese, F.   +4 more
openaire   +6 more sources

Presence of CD80 and Absence of LAT in Modulating Cellular Infiltration and HSV-1 Latency

Viruses
CD80 is the best-known costimulatory molecule for effective T cell functions. Many different reports have summarized the role of CD80 in HSV-1 and its functions in maintaining adaptive immunity, which is the main player in causing herpes stromal ...
Ujjaldeep Jaggi, Homayon Ghiasi
doaj   +2 more sources